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Associate Scientist Cell Line Development Jobs in Wisconsin

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Associate Scientist Cell Line Development information

What are some common challenges faced by Associate Scientists in Cell Line Development, and how can they be addressed?

Associate Scientists in Cell Line Development often encounter challenges such as optimizing cell growth conditions, maintaining cell line stability, and troubleshooting low productivity or contamination issues. Addressing these challenges requires strong attention to detail, effective documentation, and collaboration with cross-functional teams such as upstream process development and quality control. Regular communication with senior scientists and participation in team meetings can also help in problem-solving and ensuring project timelines are met. Staying updated on the latest techniques and technologies in cell line engineering further supports overcoming these obstacles.

What does an Associate Scientist in Cell Line Development do?

An Associate Scientist in Cell Line Development is responsible for creating and optimizing cell lines that are used in the production of biopharmaceutical products. Their work involves culturing cells, performing genetic modifications, and conducting experiments to select the best cell lines for manufacturing proteins or other biologics. They also document their findings, analyze data, and collaborate with other scientists to ensure the cell lines meet regulatory and quality standards. This role is vital in the early stages of drug development, as robust cell lines are essential for consistent and scalable production.

What is the difference between Associate Scientist Cell Line Development vs Associate Scientist Bioprocess Development?

AspectAssociate Scientist Cell Line DevelopmentAssociate Scientist Bioprocess Development
Required CredentialsBachelor's or Master's in Life Sciences, Molecular Biology, or related fieldsBachelor's or Master's in Biotechnology, Chemical Engineering, or related fields
Work EnvironmentLaboratory focused on cell line creation and characterizationLaboratory and pilot plant focused on process scale-up and manufacturing
Employer & Industry UsageBiotech and pharmaceutical companies developing cell lines for biologicsBiotech and pharma companies optimizing bioprocesses for production

Associate Scientist Cell Line Development primarily focuses on creating and characterizing cell lines for biologic production, while Associate Scientist Bioprocess Development concentrates on scaling up and optimizing manufacturing processes. Both roles require similar educational backgrounds and are essential in biologics development, but they differ in their specific focus within the biopharmaceutical pipeline.

What are the key skills and qualifications needed to thrive as an Associate Scientist in Cell Line Development, and why are they important?

To thrive as an Associate Scientist in Cell Line Development, you need a strong background in cell biology, molecular biology, and protein expression, typically supported by a relevant science degree. Familiarity with technical tools such as flow cytometry, cell culture systems, CRISPR gene editing platforms, and data analysis software is essential. Attention to detail, strong problem-solving abilities, and effective teamwork are standout soft skills in this role. These skills ensure high-quality cell line generation, reproducible results, and successful collaboration in fast-paced biopharmaceutical environments.
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Associate Scientist Cell Line Development jobs near you
Associate Scientist III, Quality Control (2nd Shift)

Associate Scientist III, Quality Control (2nd Shift)

Arrowhead Pharmaceuticals

Verona, WI • On-site

$80K - $100K/yr

Full-time, Other

Posted 8 days ago

Job description

Arrowhead Pharmaceuticals, Inc. (Nasdaq ARWR) is a commercial stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead's RNAi-based therapeutics leverage this natural pathway of gene silencing.
Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.
Arrowhead's corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.
The Position
This position is within the Quality Control structure, under the Quality Organization. An Associate Scientist III, Quality Control will support method validation and analytical testing pharmaceutical raw materials, in-process samples, finished drug substances and drug product, and/or stability sample testing activities for new drug substances and drug products. The Associate Scientist III is expected to perform several analytical techniques and make sound scientific decisions under guidance from management. All work is performed under GMP requirements. This position reports to QC Laboratory Management.
2nd shift work hours are 1 pm - 11:30 pm, Monday - Thursday, and includes a 10% shift differential.
Responsibilities
  • Performs routine analytical testing of pharmaceutical raw materials, in-process samples, finished products and/or stability samples using established test methods and procedures.
  • Support method transfers and method validation activities.
  • With guidance from laboratory leadership, works to meet project timelines and deliverables
  • Ensures that training records are up to date and in compliance
  • Perform a variety of analytical instrumentation (e.g., HPLC, GC, FT-IR, UV/Vis, KF, LCMS, Appearance, pH, Endotoxin etc.)
  • Set up various instrumentations for testing according to written test methods with little to no supervision
  • Performs analyses in a timely manner and communicate analytical or sample issues to senior staff and/or management
  • Works collaboratively with others
  • Show initiative and interest in learning new techniques and tests
  • Identify and troubleshoot analytical problems with instrumentation, general chemistry and computer applications
  • Maintain a clear, concise and accurate laboratory notebook or worksheet records.
  • Peer review test data acquired by others, as applicable.
  • Author technical documents such as OOS/atypical investigations, deviations and CAPAs
  • Demonstrate good written and verbal communication skills
  • Embraces cGMP requirements for all associated work
  • Remains flexible with changing priorities.

Requirements:
  • B.S. in Chemistry (or related field) with 3-5 years of relevant laboratory experience
  • Knowledgeable of cGMP laboratory requirements and operations
  • Familiar with analytical instrumentation, test methodology/validations, data acquisition systems, and typical cGMP policies and practices.

Wisconsin pay range
$80,000-$100,000 USD
Arrowhead provides competitive salaries and an excellent benefit package.
Candidates must have current, valid authorization to work in the country where this role is located.
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