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Associate Scientist Cell Line Development Jobs in Massachusetts

AllSTEM Connections

Biologist (3-5 years)

Boston, MA · On-site

$115K - $119K/yr

Qualifications: Scientist, Cell Engineering and Assay Development As a Scientist in Cell ... Hands-on experience with lentiviral cell line generation is required. Additional Skills/Preferences ...

C10 Labs

$100K - $136K/yr

We are seeking a highly motivated scientist to lead the development and execution of cell-based and immunology assays that will guide therapeutic discovery and development. Position Summary We are ...

UCB

Associate Scientist

Cambridge, MA · On-site

$86K - $113K/yr

... at our Boston R&D Hub located in Cambridge MA. This scientist will have responsibility for ... Generate cell models for screening and to mimic disease biology * Have accountability for achieving ...

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All JobsAssociate Scientist Cell Line Development JobsAssociate Scientist Cell Line Development Jobs in Massachusetts

Associate Scientist Cell Line Development information

What does an associate scientist in cell line development do?

An Associate Scientist in Cell Line Development is responsible for creating and optimizing cell lines that are used in the production of biopharmaceutical products. Their work involves culturing cells, performing genetic modifications, and conducting experiments to select the best cell lines for manufacturing proteins or other biologics. They also document their findings, analyze data, and collaborate with other scientists to ensure the cell lines meet regulatory and quality standards. This role is vital in the early stages of drug development, as robust cell lines are essential for consistent and scalable production.

What are the key skills and qualifications needed to thrive as an associate scientist in cell line development?

To thrive as an Associate Scientist in Cell Line Development, you need a strong background in cell biology, molecular biology, and protein expression, typically supported by a relevant science degree. Familiarity with technical tools such as flow cytometry, cell culture systems, CRISPR gene editing platforms, and data analysis software is essential. Attention to detail, strong problem-solving abilities, and effective teamwork are standout soft skills in this role. These skills ensure high-quality cell line generation, reproducible results, and successful collaboration in fast-paced biopharmaceutical environments.

What are some common challenges faced by associate scientists in cell line development, and how can they be addressed?

Associate Scientists in Cell Line Development often encounter challenges such as optimizing cell growth conditions, maintaining cell line stability, and troubleshooting low productivity or contamination issues. Addressing these challenges requires strong attention to detail, effective documentation, and collaboration with cross-functional teams such as upstream process development and quality control. Regular communication with senior scientists and participation in team meetings can also help in problem-solving and ensuring project timelines are met. Staying updated on the latest techniques and technologies in cell line engineering further supports overcoming these obstacles.

What is the difference between Associate Scientist Cell Line Development vs Associate Scientist Bioprocess Development?

AspectAssociate Scientist Cell Line DevelopmentAssociate Scientist Bioprocess Development
Required CredentialsBachelor's or Master's in Life Sciences, Molecular Biology, or related fieldsBachelor's or Master's in Biotechnology, Chemical Engineering, or related fields
Work EnvironmentLaboratory focused on cell line creation and characterizationLaboratory and pilot plant focused on process scale-up and manufacturing
Employer & Industry UsageBiotech and pharmaceutical companies developing cell lines for biologicsBiotech and pharma companies optimizing bioprocesses for production

Associate Scientist Cell Line Development primarily focuses on creating and characterizing cell lines for biologic production, while Associate Scientist Bioprocess Development concentrates on scaling up and optimizing manufacturing processes. Both roles require similar educational backgrounds and are essential in biologics development, but they differ in their specific focus within the biopharmaceutical pipeline.

What cities in Massachusetts are hiring for Associate Scientist Cell Line Development jobs?

Cities in Massachusetts with the most Associate Scientist Cell Line Development job openings:

Associate Scientist Cell Line Development jobs near you

Process Development Associate I - PRISM Cell Pooling

Broad Institute

Cambridge, MA • On-site

$50K - $70K/yr

Full-time

Medical, Dental, Vision, Life, Retirement, PTO

Posted 15 days ago

Job description

General information
Location
Cambridge, MA
Ref #
44662
Job Family
Research
Workplace
On-Site
Date published
08/07/2026
Time Type
Full time
Pay Range
$50,000.00/yr - $70,000.00/yr
Description & Requirements
The Broad Institute of MIT & Harvard is seeking an outstanding candidate for the position of Process Development Associate I within the PRISM team, a component of the Cancer Program. Dedicated to transforming medicine, the Broad Institute works to significantly accelerate the understanding and treatment of disease. As part of this important mission of the Broad, the Cancer Program is advancing the understanding of oncology therapeutics through the systematic profiling of oncology therapeutics using the PRISM technology of large-scale screening of more than 900 cell lines.
To support our mission, we are looking for a motivated and high-energy individual to join the PRISM team to manage daily, large-scale tissue culture production. By leveraging the PRISM technology, we routinely screen over 900 DNA-barcoded cell lines against hundreds of therapies in a pooled format, achieving much greater speed than conventional cell line screening methods. The true capability of PRISM stems from our deep understanding of the baseline and functional genomic characteristics of these cell lines from the Cancer Dependency Map. Each test agent evaluated yields not only viability data but also extensive genomic correlations and multivariate analyses, offering a comprehensive view of drug behavior.
The chosen candidate will be vital to the upkeep of our cell lines and cell line pools, with primary responsibilities centered on supporting scientific research through routine cell culture and molecular biology operations. This Process Development Associate I role necessitates the routine culture of at least 30 cell lines concurrently.
Responsibilities include combining 25 cell lines to generate the pools utilized in our screening processes, maintaining our cell bank of 1,000 cell lines, and plating cell pools for our large-scale screening efforts. Applicants must possess a background in cell culture alongside exemplary aseptic techniques, and uphold high quality standards through precise lab documentation and adherence to standard operating procedures. Strong communication skills are crucial for success within this collaborative team environment.
PRIMARY RESPONSIBILITIES:
  • Manage cell culture for up to 30 cell lines simultaneously to generate PRISM pools
  • Maintain our cell bank of 1000 cell lines, including barcoding new cell lines, creating new freezer stocks of cell lines, and regularly updating inventories/databases
  • Execute large-scale cell plating for production screens
  • Conduct molecular biology protocols and related quality control assays on cell lines, including PCR, DNA/RNA extraction, gel electrophoresis for mycoplasma testing, sequence submission, and STR testing sample shipments
  • Execute CTG cell viability assays as needed
  • Maintain comprehensive lab records, experimental write-ups, and processing notes using an electronic lab notebook (eLabNext)
  • Prepare and maintain stocks of reagents, solutions, and lab supplies and manage inventories
  • Perform routine maintenance on lab equipment to ensure optimal equipment functionality (e.g. plate washers, combi liquid dispensers, etc)
  • Maintain and update SOPs to accurately reflect any changes in production protocols
  • Assess the quality of PRISM cell pools utilizing an internal data visualization tool
  • Participate in team meetings to share results, plan projects, and ensure alignment with current team goals

MINIMUM QUALIFICATIONS:
  • BS/BA in Biology, Biomedical Engineering or related fields
  • 1 + year experience in a biological research environment, additional experience with mammalian cell culture and aseptic technique is preferred
  • Experience with basic molecular biology techniques, including PCR, DNA extractions, etc
  • Excellent written and oral communication skills and ability to effectively work as part of a team
  • Strong interpersonal, organizational, and analytical skills, including the ability to handle a variety of tasks in a fast-paced environment
  • Strong attention to detail, time management skills, and the ability to maintain accurate records and documentation

The Broad Institute will not offer visa sponsorship for this opportunity.
The expected base pay range for this position as listed above is based on a 40 hour per week schedule. Broad provides pay ranges representing its reasonable and good faith estimate of what the organization reasonably expects to pay for a position at the time of posting. Actual compensation will vary based on factors including but not limited to, relevant skills, experience, education, qualifications, and other factors permissible by law.
At Broad, your base pay is just one part of a comprehensive total rewards package. From day one, this role offers a competitive benefits package including medical, dental, vision, life, and disability insurance; a 401(k) retirement plan; flexible spending and health savings accounts; at least 13 paid holidays; winter closure; paid time off; parental and family care leave; and an employee assistance program, among other Broad benefits.
The Broad Institute is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, national origin, religion, age, color, sex, disability, protected veteran status, or any other characteristic protected by local, state, or federal laws, rules, or regulations.
Should you need a reasonable accommodation to complete the application or interview process, please contact recruiting@broadinstitute.org for assistance.

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