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Associate Scientist Cell Line Development Jobs in Massachusetts

Mindlance

Biologist

Worcester, MA · On-site

The scientist in this position will have several responsibilities in supporting CHO cell line development pipeline, including expression vector design, cell line engineering and genetic ...

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Associate Scientist Cell Line Development information

What are some common challenges faced by Associate Scientists in Cell Line Development, and how can they be addressed?

Associate Scientists in Cell Line Development often encounter challenges such as optimizing cell growth conditions, maintaining cell line stability, and troubleshooting low productivity or contamination issues. Addressing these challenges requires strong attention to detail, effective documentation, and collaboration with cross-functional teams such as upstream process development and quality control. Regular communication with senior scientists and participation in team meetings can also help in problem-solving and ensuring project timelines are met. Staying updated on the latest techniques and technologies in cell line engineering further supports overcoming these obstacles.

What does an Associate Scientist in Cell Line Development do?

An Associate Scientist in Cell Line Development is responsible for creating and optimizing cell lines that are used in the production of biopharmaceutical products. Their work involves culturing cells, performing genetic modifications, and conducting experiments to select the best cell lines for manufacturing proteins or other biologics. They also document their findings, analyze data, and collaborate with other scientists to ensure the cell lines meet regulatory and quality standards. This role is vital in the early stages of drug development, as robust cell lines are essential for consistent and scalable production.

What is the difference between Associate Scientist Cell Line Development vs Associate Scientist Bioprocess Development?

AspectAssociate Scientist Cell Line DevelopmentAssociate Scientist Bioprocess Development
Required CredentialsBachelor's or Master's in Life Sciences, Molecular Biology, or related fieldsBachelor's or Master's in Biotechnology, Chemical Engineering, or related fields
Work EnvironmentLaboratory focused on cell line creation and characterizationLaboratory and pilot plant focused on process scale-up and manufacturing
Employer & Industry UsageBiotech and pharmaceutical companies developing cell lines for biologicsBiotech and pharma companies optimizing bioprocesses for production

Associate Scientist Cell Line Development primarily focuses on creating and characterizing cell lines for biologic production, while Associate Scientist Bioprocess Development concentrates on scaling up and optimizing manufacturing processes. Both roles require similar educational backgrounds and are essential in biologics development, but they differ in their specific focus within the biopharmaceutical pipeline.

What are the key skills and qualifications needed to thrive as an Associate Scientist in Cell Line Development, and why are they important?

To thrive as an Associate Scientist in Cell Line Development, you need a strong background in cell biology, molecular biology, and protein expression, typically supported by a relevant science degree. Familiarity with technical tools such as flow cytometry, cell culture systems, CRISPR gene editing platforms, and data analysis software is essential. Attention to detail, strong problem-solving abilities, and effective teamwork are standout soft skills in this role. These skills ensure high-quality cell line generation, reproducible results, and successful collaboration in fast-paced biopharmaceutical environments.
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Associate Scientist Cell Line Development jobs near you
Senior Associate Scientist, AAV Cell Line Development (Contractor)

Senior Associate Scientist, AAV Cell Line Development (Contractor)

Asimov

Boston, MA • On-site

$55 - $60/hr

Contractor

Posted 23 hours ago

Job description

Our mission at Asimov is to advance humanity's ability to design living systems, enabling biotechnologies with outsized benefit to society. We're developing a mammalian synthetic biology platform––from cells to software––to enable the design and manufacture of next-generation therapeutics.

We're seeking a Senior Associate Scientist to join our Synthetic Biology team on a 6 month contract. The ideal candidate will have a proven track record performing AAV and/or lentiviral vector stable producer cell line development in an industry setting. They will be a key contributor to our team, participating in the creation of stable producer cell lines for AAV and/or lentiviral vector therapeutics and research projects to improve our cell line development workflows. They will also work closely with Asimov’s synthetic biology and process development teams. This is a unique opportunity to work at a nimble, forward-thinking synthetic biology startup and help build the future of biological engineering.


About the Role:

  • Perform AAV and/or lentiviral vector stable producer cell line development processes including transfection, cloning, characterization, and cell banking using state-of-the-art equipment

  • Perform biological assays including ddPCR, ELISA, and flow cytometry

  • Support innovation through development of novel workflows and applications

  • Support research projects to develop viral vector therapeutics with enhanced quality attributes such as empty/full ratio, potency and/or cell targeting

  • Work effectively as part of a cross-functional team in support of a synthetic biology design platform

  • Design experiments, analyze data, troubleshoot, and maintain detailed records

  • Represent the cell line development function on project teams, making decisions for cell line activities and effectively communicating results, progress and plans

  • This is a full-time, 6-month contract position providing maternity leave coverage. While the role is intended to support this temporary need, there may be an opportunity to extend the contract or transition to a permanent position based on business needs.

About You:

  • B.S or M.S. in Biological Engineering, Virology, Cell Biology, Molecular Biology, or a related field

  • 5+ years of hands-on experience in AAV and/or lentiviral vector producer cell line development in support of GMP production of cell or gene therapies

  • Experience performing transfections, viral transductions, flow cytometry, and quantitative gene expression analyses (ddPCR, qPCR, ELISA) is highly desired

  • Experience with viral genome engineering, and/or host cell genome engineering related to virus production or producer cell line technologies is highly desired

  • Strong written and verbal communication skills required


We're fueled by a vision to transform biological engineering into a fully-fledged engineering discipline. Should you join our team, you will grow with a constantly evolving organization and push the frontiers of synthetic biology. Company culture is key to Asimov, and ours is a culture of recombination; we believe that our mission can only be achieved by bringing together a diverse team with a mixture of backgrounds and perspectives.