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Associate Scientist Cell Line Development Jobs in California

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Associate Scientist Cell Line Development information

What are some common challenges faced by Associate Scientists in Cell Line Development, and how can they be addressed?

Associate Scientists in Cell Line Development often encounter challenges such as optimizing cell growth conditions, maintaining cell line stability, and troubleshooting low productivity or contamination issues. Addressing these challenges requires strong attention to detail, effective documentation, and collaboration with cross-functional teams such as upstream process development and quality control. Regular communication with senior scientists and participation in team meetings can also help in problem-solving and ensuring project timelines are met. Staying updated on the latest techniques and technologies in cell line engineering further supports overcoming these obstacles.

What does an Associate Scientist in Cell Line Development do?

An Associate Scientist in Cell Line Development is responsible for creating and optimizing cell lines that are used in the production of biopharmaceutical products. Their work involves culturing cells, performing genetic modifications, and conducting experiments to select the best cell lines for manufacturing proteins or other biologics. They also document their findings, analyze data, and collaborate with other scientists to ensure the cell lines meet regulatory and quality standards. This role is vital in the early stages of drug development, as robust cell lines are essential for consistent and scalable production.

What is the difference between Associate Scientist Cell Line Development vs Associate Scientist Bioprocess Development?

AspectAssociate Scientist Cell Line DevelopmentAssociate Scientist Bioprocess Development
Required CredentialsBachelor's or Master's in Life Sciences, Molecular Biology, or related fieldsBachelor's or Master's in Biotechnology, Chemical Engineering, or related fields
Work EnvironmentLaboratory focused on cell line creation and characterizationLaboratory and pilot plant focused on process scale-up and manufacturing
Employer & Industry UsageBiotech and pharmaceutical companies developing cell lines for biologicsBiotech and pharma companies optimizing bioprocesses for production

Associate Scientist Cell Line Development primarily focuses on creating and characterizing cell lines for biologic production, while Associate Scientist Bioprocess Development concentrates on scaling up and optimizing manufacturing processes. Both roles require similar educational backgrounds and are essential in biologics development, but they differ in their specific focus within the biopharmaceutical pipeline.

What are the key skills and qualifications needed to thrive as an Associate Scientist in Cell Line Development, and why are they important?

To thrive as an Associate Scientist in Cell Line Development, you need a strong background in cell biology, molecular biology, and protein expression, typically supported by a relevant science degree. Familiarity with technical tools such as flow cytometry, cell culture systems, CRISPR gene editing platforms, and data analysis software is essential. Attention to detail, strong problem-solving abilities, and effective teamwork are standout soft skills in this role. These skills ensure high-quality cell line generation, reproducible results, and successful collaboration in fast-paced biopharmaceutical environments.
What are popular job titles related to Associate Scientist Cell Line Development jobs in California? For Associate Scientist Cell Line Development jobs in California, the most frequently searched job titles are:
What job categories do people searching Associate Scientist Cell Line Development jobs in California look for? The top searched job categories for Associate Scientist Cell Line Development jobs in California are:
What cities in California are hiring for Associate Scientist Cell Line Development jobs? Cities in California with the most Associate Scientist Cell Line Development job openings:
Scientist 1, In Vitro Pharmacology

Scientist 1, In Vitro Pharmacology

Crinetics Pharmaceuticals

San Diego, CA โ€ข On-site

$106K - $132K/yr

Full-time

Medical, Dental, Vision, Life, Retirement, PTO

Posted 9 days ago


Job description

Crinetics is a pharmaceutical company based in San Diego, California, developing much-needed therapies for people with endocrine diseases and endocrine-related tumors. We were founded by a dedicated team of scientists with the simple belief that better therapies developed from rigorous innovation can lead to better lives. Our work continues to make a real difference in the lives of patients. We have a prolific discovery engine and a robust preclinical and clinical development pipeline. We are driven by science with a patient-centric and team-oriented culture. Crinetics is known for its inclusive workplace culture. We are also a dog-friendly workplace. This is an exciting time to join Crinetics as we shape our organization into the world's premier fully integrated endocrine company from discovery to patients. Join our team as we transform the lives of others.
Position Summary:
The Scientist 1, In Vitro role works closely with colleagues within the Biology, Chemistry, and Preclinical Development teams to evaluate new drug modalities by performing mechanistic studies and participate in discovery and translational efforts aimed at identifying and characterizing novel targeted therapeutic targets. This role works in a dynamic environment to help advance programs from discovery into development, as part of a multidisciplinary team.
Essential Job Functions and Responsibilities:
These may include but are not limited to:
  • Develop and maintain multiple cell lines independently.
  • Implement excellent aseptic technique required for primary cell culture.
  • Design, optimize, and validate pharmacology assays.
  • Perform, analyze, and interpret assays independently.
  • Maintain electronic laboratory notebooks in a timely and accurate manner.
  • Write standard operating protocols.
  • Participate in cross-functional drug discovery teams and interact with cross-functional groups effectively.
  • Provide guidance and training to junior scientists.
  • Interpret and present data and findings to cross-functional teams and leadership.
  • Support the organization in maintaining a work environment focused on scientific integrity and quality, and one that fosters learning, open communication, collaboration, and teamwork.
  • Other duties as assigned.

Education and Experience:
Required:
  • Ph.D. in Biology, Behavioral Pharmacology, Physiology, Neuroscience, or related discipline with research experience in disease-related biology. Applicants with BS or MS degrees may apply but must demonstrate a minimum of 8 to 10 years of significant and relevant experience in pharmaceutical or life sciences industry.
  • Strong cell culture expertise with proven experience in cell line development
  • Experience with basic molecular biology techniques using DNA, RNA, and protein.
  • Strong knowledge of molecular biology techniques to support cell line generation.
  • Detail-oriented, with excellent organization and record-keeping skills.
  • Capable of working both independently with minimal oversight and in a collaborative environment.
  • Outstanding written and oral presentation capabilities,
  • Software knowledge in Windows, MS Office (Outlook, Word, Excel, PowerPoint, SharePoint, Teams), GraphPad Prism, among others as required.

Preferred:
  • Experience in RNAi (siRNA, miRNA, ASOs) design and delivery.
  • Experience in developing cancer, immunology, in vitro cell-based assays

Physical Demands and Work Environment:
Physical Activities: On a continuous basis, sit at desk for a long period of time; intermittently answer telephone and write or use a keyboard to communicate through written means. Some walking and lifting up to 25 lbs. may be required. The noise level in the work environment is typically low to moderate. The physical demands described above are representative of those that must be met by an employee to successfully perform the essential functions and responsibilities of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions and responsibilities.
Laboratory Activities (if applicable): Biology and chemical laboratory environment experience needed. Environmental health and safety requirements also apply.
Travel:
You may be required to travel for up to 5% of your time.
Equal Opportunity Employer:
Crinetics is proud to be an Equal Opportunity Employer. We provide equal employment opportunities to all employees and employment applicants without regard to unlawful considerations of sex, sexual orientation, gender (including gender identity and/or expression), pregnancy, race, color, creed, national or ethnic origin, citizenship status, religion or similar philosophical beliefs, disability, marital and civil union status, age, genetic information, veteran status or any personal attribute or characteristic that is protected by applicable local, state or federal laws.
Salary Range
The salary range for this position is: $106,000 - $132,000.
In addition to your base pay, our total rewards program consists of a discretionary annual target bonus, stock options, ESPP, and 401k match. We also provide top-notch health insurance plans for employees (and their families) to include medical, dental, vision and basic life insurance, 20 days of PTO, 10 paid holidays, and a winter company shutdown.