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Associate Downstream Process Development Scientist Jobs in Durham, NC

AskBio

Sr. Scientist, DNA Development

Durham, NC · On-site

Pioneering science to create transformative molecular medicines. Our mission: Lead innovative ... reports to the Process Development Associate Director/Director. Job Responsibilities

AskBio

Sr. Scientist, DNA Development

Durham, NC · On-site

Pioneering science to create transformative molecular medicines. Our mission: Lead innovative ... reports to the Process Development Associate Director/Director. Job Responsibilities

KBI Biopharma, Inc.

Senior Director, MS&T

Durham, NC · On-site

$180 - $240/hr

... Scientists and will collaborate with Process Development, Quality, Supply Chain, Facilities ... Must have demonstrated biologics expertise in upstream or downstream processing and operations Must ...

KBI Biopharma, Inc.

Senior Director, MS&T

Durham, NC · On-site

... Scientists and will collaborate with Process Development, Quality, Supply Chain, Facilities ... Oversees and maintains the procedures, business processes and tools for downstream tech transfer.

KBI Biopharma, Inc.

Senior Director, MS&T

Durham, NC · On-site

... Scientists and will collaborate with Process Development, Quality, Supply Chain, Facilities ... Oversees and maintains the procedures, business processes and tools for downstream tech transfer.

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All JobsAssociate Downstream Process Development Scientist JobsAssociate Downstream Process Development Scientist Jobs in Durham, NC

Associate Downstream Process Development Scientist information

See Durham, NC salary details

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$47

How much do associate downstream process development scientist jobs pay per hour?

As of Aug 22, 2026, the average hourly pay for associate downstream process development scientist in Durham, NC is $32.55, according to ZipRecruiter salary data. Most workers in this role earn between $26.73 and $39.95 per hour, depending on experience, location, and employer.

What is an associate downstream process development scientist?

An Associate Downstream Process Development Scientist is a professional who works in the biotechnology or pharmaceutical industry, focusing on developing and optimizing processes that purify biological products, such as proteins or antibodies, after they have been produced by cells. Their work is crucial for ensuring the final product meets quality and safety standards before it is used in research or clinical applications. They typically perform laboratory experiments, analyze data, and collaborate with other scientists and engineers to improve yield and efficiency. This role is often entry-level or early-career, providing hands-on experience in process development and technical troubleshooting.

What are some typical challenges faced by an associate downstream process development scientist, and how can they be addressed?

Associate Downstream Process Development Scientists often encounter challenges such as optimizing purification processes, troubleshooting equipment performance, and ensuring batch-to-batch consistency. These challenges can be addressed by maintaining meticulous documentation, collaborating closely with upstream and analytical teams, and staying current with best practices in chromatography and filtration. Proactively seeking feedback from experienced colleagues and participating in cross-functional meetings can also help in identifying solutions and improving process efficiency.

What are the key skills and qualifications needed to thrive as an associate downstream process development scientist, and why are they important?

To excel as an Associate Downstream Process Development Scientist, you need a solid understanding of biochemistry, chemical engineering, and downstream purification techniques, often supported by a bachelor's or master's degree in a life science or engineering discipline. Familiarity with chromatographic systems (such as AKTA), filtration equipment, and analytical tools, as well as knowledge of GMP/GLP regulations, is typically required. Strong problem-solving, attention to detail, and effective teamwork and communication skills help you navigate complex experiments and collaborate with cross-functional teams. These skills ensure efficient process optimization, compliance with regulatory standards, and successful development of biopharmaceutical products.

What is the difference between Associate Downstream Process Development Scientist vs Associate Upstream Process Development Scientist?

AspectAssociate Downstream Process Development ScientistAssociate Upstream Process Development Scientist
Primary FocusPurification and recovery of bioproductsCell culture and fermentation processes
Required SkillsProtein purification, chromatography, filtrationCell culture, bioreactor operation, media preparation
Work EnvironmentLaboratories, manufacturing facilitiesLaboratories, bioreactor labs
Common CertificationsBiotech or bioprocessing certificationsBiotech or bioprocessing certifications

Both roles are essential in biopharmaceutical development, focusing on different stages of the production process. The Associate Downstream Process Development Scientist specializes in purification techniques, while the Associate Upstream Process Development Scientist concentrates on cell growth and fermentation. Understanding these distinctions helps candidates target their skills and career paths effectively.

What are the most commonly searched types of Downstream Process Development Scientist jobs in Durham, NC?

The most popular types of Downstream Process Development Scientist jobs in Durham, NC are:

Associate Downstream Process Development Scientist jobs near you

Upstream Process Development Associate I/II

KBI Biopharma, Inc.

Durham, NC • On-site

$50K - $70K/yr

Full-time

Medical, Dental, Vision, Retirement, PTO

Posted 17 days ago

KBI Biopharma rating

6.5

Company rating: 6.5 out of 10

Based on 6 frontline employees who took The Breakroom Quiz

Job description

Position Summary:

KBI Biopharma seeks to fill a role for Upstream Cell Culture Process Development Associate. This person will lead and assist in cell culture and harvest projects for mammalian cell lines (mainly CHO variants) in support of process development, scale-up, and technology transfer to cGMP manufacturing.

Position Responsibilities:

  • Assist the team in the set-up, operation, and associated analysis of cell culture and bioreactor processes including bioreactor preparation, autoclaving, inoculation, sampling, feeding, data entry, and data analysis for shake flask and various scale bioreactors (ambr15, ambr250, 3 L & 15 L glass bioreactors, 50 L and 200 L Xcellerex single-use bioreactors).

  • Lead in maintaining and monitoring process development experiments in shake flasks and bioreactors. Required to perform calculations for growth rate, specific productivity, and bioreactor agitation and gassing scale up/scale down.

  • Perform data entry and plotting, generate presentations and support writing of technical reports using MS Office (Excel, PowerPoint and Word).

  • Maintain detailed batch sheets and data binders with shake flask and bioreactor test results following good documentation practices (GDP).

  • Assist in data analysis using statistical software like Design Expert (DOE), JMP, etc. and help with writing technical documents and reports.

  • Maintains a cell culture-specific project plan, including raw materials and equipment availability, in preparation of laboratory and pilot- scale runs.

  • Serves as a participant on process development teams and coaches junior individuals on cell culture techniques.

  • If necessary, interacts with client to present data, provide responses to client queries and help take projects from start to finish, either independently or in teams of 2-3 individuals.

  • Assist in process transfer from process development to manufacturing.

  • Experience in medium development will be a plus

Position Requirements:

  • Bachelor's and 1-3+ years' experience, or master's degree and 2+ years' experience in Chemical Engineering, Biotechnology or related area.

  • Working knowledge of mammalian cell culture.

  • Advanced ability with Microsoft Office (Excel, PowerPoint and Word).

  • Demonstrates ability to work both independently and as a member of a team.

  • Excellent customer service skills and the ability to meet strict client deadlines.

  • Flexibility of hours to support cell culture processes over weekends (2-4 weekend days per month) and holidays. Weekend and holiday hours are compensated as a premium in addition to base salary.

Salary: $50,000-$70,000

Salary range provided per current averages and expectations. The salary and job title for this opening will be based on the selected candidate's qualifications and experience and may be outside this range. KBI has a robust total rewards strategy which includes an annual bonus structure for all employees, medical, dental, and vision coverage, paid PTO and holidays, Sabbatical program, 401K matching with 100% vesting in 60 days and employee recognition programs.

KBI Biopharma, Inc. is an EEO/AA employer and actively seeks to diversify its work force. Therefore, all qualified applicants, regardless of race, color, national origin, religion, gender, gender identity, sexual orientation, age, disability or veteran status, are strongly encouraged to apply.

I understand that neither the completion of this application nor any other part of my consideration for employment establishes any obligation for KBI Biopharma, Inc. to hire me. If I am hired, I understand that either KBI Biopharma, Inc. or I can terminate my employment at any time and for any reason, with or without cause and without prior notice. I understand that no representative of KBI Biopharma, Inc. has the authority to make any assurance to the contrary.

I attest with my signature below that I have given to KBI Biopharma, Inc. true and complete information on this application. No requested information has been concealed. I authorize KBI Biopharma, Inc. to contact references provided for employment reference checks. If any information I have provided is untrue, or if I have concealed material information, I understand that this will constitute cause for the denial of employment or immediate dismissal.

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