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Analytical Method Development Scientist Jobs in California

Amgen

Analytical Scientist

Thousand Oaks, CA

Career Category Scientific Join Amgen's Mission of Serving Patients At Amgen, if you feel like you ... Define analytical control strategies and implement methodologies for development of pivotal phase ...

SSi People

Senior Scientist

Thousand Oaks, CA

$95K - $131K/yr

Senior Scientist - Analytical Development · Location: Thousand Oaks, CA Position Summary With ... Perform method development to deliver the analytical control strategy for the small molecule ...

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Analytical Method Development Scientist information

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How much do analytical method development scientist jobs pay per hour?

As of Jun 16, 2026, the average hourly pay for analytical method development scientist in California is $41.53, according to ZipRecruiter salary data. Most workers in this role earn between $31.06 and $47.93 per hour, depending on experience, location, and employer.

What does an Analytical Method Development Scientist do?

An Analytical Method Development Scientist is responsible for designing, developing, and validating analytical methods used to test and analyze chemical compounds, pharmaceuticals, or other materials. They ensure that the methods are accurate, reliable, and compliant with regulatory standards. This role involves working with advanced laboratory instruments, troubleshooting analytical issues, and documenting procedures for use in research, quality control, or manufacturing environments.

What are the key skills and qualifications needed to thrive as an Analytical Method Development Scientist, and why are they important?

To thrive as an Analytical Method Development Scientist, a strong background in chemistry, analytical techniques, and method validation—often supported by a relevant degree in chemistry or pharmaceutical sciences—is essential. Familiarity with laboratory instrumentation such as HPLC, GC, MS, and software for data analysis, as well as knowledge of regulatory guidelines like ICH and FDA, is typically required. Attention to detail, problem-solving abilities, and effective communication are vital soft skills for success in this role. These skills ensure reliable method development, regulatory compliance, and effective collaboration within multidisciplinary scientific teams.

What are the typical challenges faced by an Analytical Method Development Scientist when transferring methods to quality control or manufacturing teams?

One common challenge for Analytical Method Development Scientists is ensuring that newly developed analytical methods are robust and reproducible when transferred to quality control or manufacturing teams. Differences in equipment, sample matrices, or operator technique can impact results, so thorough method validation and clear documentation are essential. Scientists often work closely with cross-functional teams to provide training, troubleshoot issues, and adapt protocols as needed. Successfully managing these transitions helps maintain product quality and regulatory compliance.

What is the difference between Analytical Method Development Scientist vs Analytical Chemist?

AspectAnalytical Method Development ScientistAnalytical Chemist
Primary FocusDeveloping and validating new analytical methodsPerforming routine analysis and testing
Work EnvironmentResearch labs, R&D departmentsQuality control labs, manufacturing facilities
CredentialsBachelor's or Master's in Chemistry or related field; experience in method developmentBachelor's degree in Chemistry or related field; experience in analytical testing

While both roles involve analytical testing, the Analytical Method Development Scientist primarily focuses on creating and validating new analytical methods, often in research settings. In contrast, the Analytical Chemist typically performs routine testing to ensure product quality in manufacturing or quality control labs.

What are popular job titles related to Analytical Method Development Scientist jobs in California? For Analytical Method Development Scientist jobs in California, the most frequently searched job titles are:
What job categories do people searching Analytical Method Development Scientist jobs in California look for? The top searched job categories for Analytical Method Development Scientist jobs in California are:
Analytical Method Development Scientist jobs near you
Infographic showing various Analytical Method Development Scientist job openings in California as of June 2026, with employment types broken down into 67% Full Time, and 33% Contract. Highlights an 100% In-person job distribution, with an average salary of $86,373 per year, or $41.5 per hour.

Scientist, Analytical Development and Quality Control

Nurix

Brisbane, CA • On-site

$143K - $161K/yr

Full-time

Posted 5 days ago

Job description

Company
Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix's dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine's next chapter with a new script to outmatch disease.
Position
Nurix Therapeutics seeks an experienced Scientist to join the Analytical Development and Quality Control group. The Scientist will conduct analytical method development and material characterization studies to inform drug substance and drug product development. They will also provide operational oversight at external CDMO/CTL partners, manage reference standards and impurity markers, collaborate in CMC risk management, and author technical reports.
In Nurix's laboratories, the Scientist will characterize material attributes and impurities by high resolution mass spectrometric and multidimensional chromatographic techniques. They will determine impurity structures, characterize material stability, and elucidate mechanisms of degradation. They will employ state of the art QbD approaches to develop and troubleshoot chromatographic test methods to accelerate and derisk QC activities performed externally at CDMOs and CTLs. The Scientist will critically evaluate characterization data and communicate results in multidisciplinary teams.
The ideal candidate must have demonstrated expertise in mass spectrometry and hands-on experience with liquid chromatography. Hands-on experience with two-dimensional liquid chromatography is a plus.
This position is onsite at Nurix headquarters in Brisbane, CA.
Key responsibilities
  • Characterization and development studies at our internal laboratory:
    • 2D-LC for impurity profiling of complex samples, derisking HPLC test procedures, and adaptation of incompatible methods to mass spectrometry
    • Structural elucidation by high resolution Orbitrap Tribrid Mass Spectrometry
    • QbD HPLC method development using multivariate DOE software
    • Forced degradation and elucidation of degradation mechanisms
    • Accelerated predictive stability studies and modeling of packaging configurations and long term stability
  • Authorship of technical documents such as analytical development reports, stability reports, and storage statements
  • Management of reference standards and impurity markers
  • Manage and organize documentation and data
  • Contribute to protocol development and oversight/troubleshooting of method transfers
  • Liaise with Medicinal Chemistry, Bioanalytical, DMPK, and Preclinical departments
  • Compliance with cGMP quality standards and internal SOPs
  • Travel up to 5%

Required Qualifications
  • Advanced degree in a relevant discipline (Chemistry, Pharmaceutics, or related field). BS with 10+ years, MS degree with 6+ years, or PhD with up to 4 years of relevant experience
  • Expertise in operation and maintenance of mass spectrometers
  • Experience in HPLC operation and method development
  • Ability to critically interpret data and articulate technical concepts in cross functional teams
  • Ability to ensure assigned activities are completed to the satisfaction of project timelines
  • Strong interpersonal skills that foster collaboration within and outside of the organization

Bonus Qualifications
  • Experience with accurate mass instrumentation such as Orbitrap Tribrid mass spectrometers
  • Experience in operation of 2D-LC
  • Experience in the determination of structures of small molecule impurities and/or metabolites
  • Experience protein and/or ADC characterization by mass spectrometry
  • Familiarity with gas chromatography, NMR, particle size analysis, solid state characterization, dissolution, ICP-MS/OES, and/or FTIR
  • Experience with reference standard management, stability programs, and/or method validation
  • Familiarity with ICH guidelines, cGMPs, and pharmacopeial chapters

Fit with Nurix Culture and Values
  • Strong team orientation; highly collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view

Salary Range
Scientist I : $123,841--$144,272
Scientist II: $143,260 -$161,064
Application Process
Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.
Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix. By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/).

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