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Analytical Development Small Molecule Jobs (NOW HIRING)

Vrtx

Analytical Development Principal Scientist

Boston, MA · On-site

$140K - $211K/yr

Vertex is seeking an experienced scientist eager to help develop cutting-edge small molecules and ... As a member of the Drug Substance Control Strategy team in Analytical Development, this role will ...

Iambic Therapeutics, Inc

$224K - $310K/yr

This leadership role will provide scientific, strategic, and operational oversight of Analytical Development and Quality Control activities across Iambic's small-molecule portfolio, supporting ...

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How much do analytical development small molecule jobs pay per year?

As of Sep 9, 2026, the average yearly pay for analytical development small molecule in the United States is $53,418.00, according to ZipRecruiter salary data. Most workers in this role earn between $42,500.00 and $60,000.00 per year, depending on experience, location, and employer.

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Infographic showing various Analytical Development Small Molecule job openings in the United States as of September 2026, with employment types broken down into 1% Internship, 1% As Needed, 82% Full Time, 14% Part Time, and 2% Contract. Highlights an 87% Physical, 2% Hybrid, and 11% Remote job distribution, with an average salary of $53,418 per year, or $25.7 per hour.

Senior Scientist I Analytical Development

South San Francisco, CA • On-site

Alumis
See more jobs at Alumisexternal

$112K - $135K/yr

Full-time

Medical, PTO

Re-posted 11 days ago

Job description

Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients.
The small molecule CMC team is seeking highly motivated Sr. Scientist I of Analytical Development to help build our dynamic small molecule CMC group at Alumis. The successful candidate will help to support the analytical development and quality control activities from the preclinical phase through late-stage clinical development. Having analytical development expertise and experience in working with CMOs/CTLs, coupled with thorough understanding of the associated quality and regulatory awareness are key assets.
RESPONSIBILITIES
  • Support development, validation, and transfer of analytical methods to support starting material, intermediate, drug substance and drug product testing at CMOs/CTLs
  • Execute and/or support the in-house method development activities using UPLC/HPLC, LC-MS, KF, and dissolution instrumentation and techniques for Phase 1 to late-stage drug development
  • Review CMO/CTL analytical data (in-process, release, and stability data), protocols and reports
  • Trend stability and release data using statistical methods
  • Assist in investigation for various non-conformance events at CMOs/CTLs
  • Collaborate with CMC team, QA and CMOs/CTLs towards timely generation and approval of documents
  • Communicate scientific results (oral and written) in a clear and concise manner within cross-functional teams
  • Author technical reports and documents in support of regulatory filing
  • Assist in preparation of CMC documents for regulatory submissions (IND, IMPD, and/or NDA)

THE IDEAL CANDIDATE
  • BS/MS in chemistry or pharmaceutical sciences with 5+ years of experience in analytical development
  • Experience with analytical techniques for small drug molecules and oral solid formulations required, including UPLC/HPLC, LC-MS, KF, dissolution testing, IR, particle size analysis, and solid-state characterization techniques
  • Proven track record in applying analytical techniques to solve challenging problems
  • Experience in working with CMOs and CTLs
  • Experience in early to late-stage drug development
  • Strong organizational and communication skills
  • Comfortable in a fast-paced small company environment and a strong team player
  • Experience and knowledge in ICH, cGMP and regulatory requirements

This position is located in South San Francisco, CA. We are not considering fully remote applicants.
The salary range for this position is $112,000 USD to $135,000 USD annually. This salary range is an estimate, and the actual salary may vary based on the Company's compensation practices.
Alumis Inc. is an equal opportunity employer.
Alumis compensation packages include generous stock option grants for all employees as well as an annual bonus program.
Other benefits include:
  • Health insurance premiums paid at 90% for employee, 80% for dependents
  • Free access to Genentech Bus & Ferry Share program
  • $100 monthly cell phone stipend
  • Unlimited PTO for Exempt employees
  • Free onsite gym and a kitchen stocked with yummy snacks and drinks!

We are a hard-working, collaborative team on a mission to transform patient's lives-- and we aspire to elevate, challenge and nurture one another along the way.
Alumis Inc. is an equal opportunity employer.

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