An American Pickers job involves traveling to different locations to find and buy valuable antiques, collectibles, and unique items from private sellers, barns, garages, and storage units. Pickers negotiate prices, assess the value of items, and often resell them to collectors, antique shops, or restoration businesses. The job requires a keen eye for valuable items, strong negotiation skills, and knowledge of history and market trends. Many American Pickers work independently or for businesses that specialize in antiques and vintage goods.