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Thecentermemphis

$104 - $186/hr

Leads the operation, maintenance, and reliability of electrical infrastructure, ensuring safe, continuous, and compliant performance of power systems in mission-critical environments. Oversees ...

Thecentermemphis

$104 - $186/hr

Under the general supervision of the Departmental Director of Nursing, the Nurse Manager is accountable for promoting high quality patient care through efficient and effective management of a defined ...

Thecentermemphis

$90 - $140/hr

ProLift Rigging is a privately owned, purpose-driven industrial construction company that has a unique, opportunistic, and growth-oriented culture. OUR PURPOSE To acknowledge and glorify God by ...

Thecentermemphis

HVAC Controls Engineer

Memphis, TN · On-site

Responsible for supporting the monitoring, maintenance, troubleshooting, and optimization of building automation systems (BAS), HVAC systems, and other critical infrastructure. This role ensures ...

Thecentermemphis

Nurse Manager: Outpatient

Memphis, TN · On-site

$104 - $186/hr

Under the general supervision of the Departmental Director of Nursing, the Nurse Manager is accountable for promoting high quality patient care through efficient and effective management of a defined ...

Thecentermemphis

$120 - $180/hr

At ALSAC you do more than make a living; you make a difference.We like people who are different... because we're different, too. As one of the world's most iconic and respected nonprofits, we know ...

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Principal Scientist in Chemical Induced Proximity

Thecentermemphis

Memphis, TN • On-site

$150 - $200/hr

Other

Medical, Dental, Vision, Retirement

Re-posted 19 days ago

Job description

Responsibilities
  • Drive strategic decisions throughout various stages of the small molecule drug discovery process focusing on chemically induced proximity platforms.
  • Set up the chemistry strategy for projects and advance drug discovery programs by collaborating cross‑functionally within departmental centers and various institutional departments.
  • Lead and manage a team of scientists and large‑scale, multidisciplinary projects through proactive research collaboration, providing direction in a specific area of expertise.
  • Recruit, grow, guide, and mentor junior staff.
  • Remain at the forefront of induced proximity platforms, including PROTACs, molecular glues, and other biphenolic or allosteric modulators.
  • Evaluate new technologies, chemical tools, and screening platforms that accelerate the development of proximity‑based therapeutics.
  • Design and optimize focused chemical libraries to identify hits, leads, and drug candidates that induce selective protein interactions and cellular phenotypic changes.
  • Maintain collaborative partnerships while ensuring recognition on collaborating publications and patents.
  • Lead and manage contract research organizations and external chemistry partners worldwide.
  • Oversee structure‑activity relationship studies to enhance potency, selectivity, and drug‑like properties of candidate molecules; improve pharmacokinetic, pharmacodynamic, and toxicological profiles in collaboration with ADMET and DMPK teams.
  • Serve as functional expert in due diligence for assets in‑licensing and discovery partnerships.
  • Lead publication efforts in high‑impact scientific journals.
Qualifications
  • Experience in drug discovery within the pharma/biotech industry highly preferred.
  • Experience with computational design or AI/ML preferred.
  • PhD with management experience preferred.
Minimum Education and/or Training
  • Bachelor’s degree in a relevant scientific area is required.
  • PhD preferred.
Minimum Experience
  • Fifteen (15) years of relevant work experience required with a Bachelor’s degree.
  • Thirteen (13) years of relevant work experience required with a Master’s degree.
  • Ten (10) years of relevant work experience required with a PhD.
Benefits

St. Jude Children’s Research Hospital provides employees with high‑quality benefits choices, covering medical premiums for employees with low additional costs for dependents. Benefits include medical & prescription drug plans, dental plan, vision plan, financial security, retirement plan, living‑well employee wellness program, time‑off programs, educational benefits and family friendly benefits.

Equal Opportunity Employer

St. Jude is an Equal Opportunity Employer.

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