Tempus AI

Job Summary:
Tempus AI is focused on precision medicine and advancing the healthcare industry through AI technology. The Senior Scientist II will lead the development of agentic frameworks for automating the discovery of predictive models in oncology, collaborating with various teams to innovate on scientific methodologies.
Responsibilities:
• Design and build complex, state-of-the-art agentic workflows.
• Develop agents capable of long-horizon planning, tool use and "co-scientist" reasoning.
• Leverage oncology foundation models to integrate DNA, RNA, H&E, and clinical data into predictive algorithms.
• Collaborate with clinical scientists and pharma partners to define high-value use cases, such as clinical trial design support and treatment de-escalation.
Qualifications:
Required:
• PhD (or Masters degree with 5+ years of relevant experience).
• Plus an additional 2+ years of relevant industry or post-doctoral experience that involves medicine and AI.
• Quantitative and computational skills, specifically in AI agent based workflows (e.g. Applied Machine Learning, Generative AI, Mathematics, biostatistics).
• Biological, medical, translational or drug development knowledge and data (e.g. oncology, RWE, medical science, or clinical drug development).
• Expert-level proficiency in Python and orchestration frameworks, specifically LangGraph (strongly preferred) or similar.
• Experience building deep agents with complex state management and graphs.
• Deep knowledge of prompt engineering, RAG (Retrieval-Augmented Generation), function calling, and evaluating non-deterministic LLM outputs.
• Strong foundation in survival analysis (CoxPH, RSF, NN) and evaluation metrics for oncology models.
• Adherence to software best practices (unit testing, git) and experience designing scalable systems.
• Experience working with clinical trial or real-world data, clinical guidelines (e.g., NCCN for oncology) and emerging RWE methodologies.
• Track record of success: proven in peer reviewed publications or other proven impact.
• Excellent written and verbal communication skills, with the ability to present complex information clearly and persuasively to diverse audiences.
• Thrive in a fast-paced environment and willing to shift priorities seamlessly.
Preferred:
• Experience in integrative modeling of multi-modal clinical and omics data, preferably with multimodal embeddings and foundation models.
• Strong understanding of data and artificial intelligence in Oncology.
• Understanding of cancer biology and clinical data.
• Experience with deploying ML models in cloud environments.
Company:
Tempus is making precision medicine a reality by applying AI in healthcare, deriving insights from our expansive library of clinical data and molecular data. Founded in 2015, the company is headquartered in Chicago, USA, with a team of 1001-5000 employees. The company is currently Late Stage.