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The Research Site Manager at Iterative Health is the operational backbone of our clinical research sites. This role owns the day-to-day execution of clinical trial activities - managing site staff, driving enrollment performance, and ensuring every study runs with the quality, compliance, and efficiency our patients and sponsors depend on. The ideal candidate is an experienced clinical research professional who is equally comfortable leading a team, solving operational problems, and rolling up their sleeves as a backup CRC when the team needs it. If you thrive in a fast-paced, high-ownership environment and are energized by building something that works, this role is for you. 

Where You'll Drive Impact 

• Manage day-to-day activities across research site(s), including staff management, problem-solving, and operational planning.
• Create and implement standardized, well-documented clinic workflows that drive operational excellence and support site goal achievement.
• Attend all site selection visits and site initiation visits (SIVs).
• Oversee inventory of study supplies and ensure adequate stock levels at all times.
• Manage site-level purchasing and expenses in line with cost guidelines and profitability goals.
• Act as assigned or backup CRC as needed to manage team workloads while prioritizing site leadership responsibilities.
• Own the full employee lifecycle for site staff (CRCs and RAs), including hiring, onboarding, assignments, development, performance reviews, and offboarding.
• Ensure timely completion of tasks in EMR and CTMS by CRCs and RAs.
• Lead onsite training of clinical operations staff, including onboarding and study initiation visits.
• Monitor timelines and address issues when performance standards are not met.
• Review, approve, and submit timesheets.
• Work closely with Iterative Health management to develop strategies to meet performance targets around study enrollment, timeliness, and overall site health.
• Meet assigned productivity and quality metrics; meet regularly with coordinators to ensure they meet goals and escalate systemic barriers to the Iterative Health central team.
• Follow up on all monitoring visit action items in a timely manner.
• Maintain effective and ongoing communication with CROs and sponsors.
• Work closely with Principal Investigators and referring physicians to build understanding and enthusiasm for research opportunities for patients.
• Maintain effective communication between site staff, Principal Investigators, and Iterative Health management, including conducting regular site research meetings to discuss study progress and enrollment.
• Identify and manage appropriate third-party vendors; partner with the central Iterative Health team to ensure contracts are fully executed prior to study activation.
• Protect the rights and welfare of all human research participants involved in research.
• Cooperate with Iterative Health research compliance and monitoring efforts regarding the access, use, and disclosure of PHI; report instances of noncompliance to the appropriate compliance office.
• Assess problem situations to identify causes, gather and process relevant information, generate possible solutions, and make recommendations to management.
• Performs related duties as requested

What You Bring to the Team 

• Bachelor's degree from an accredited institution; science disciplines (biology, chemistry, etc.) preferred, or an equivalent combination of education and experience.
• Minimum 3 years of experience as a senior Clinical Research Coordinator; some management experience preferred.
• Strong written and verbal communication skills.
• Ability to read, interpret, and apply clinic policies and research protocols.
• Proficiency in standard office software; experience with EMR and CTMS platforms preferred.
• Highly organized with the ability to manage multiple priorities and meet deadlines with or without direct supervision.
• Strong problem-solving skills and ability to make sound decisions under pressure.
• Ability to interact professionally with staff, investigators, sponsors, and cross-functional partners.
• Willingness to travel across facility sites and occasionally to company meetings.

• GI and hepatology clinical trial experience.
• Prior experience in a site management or team leadership role within a clinical research environment.
• Familiarity with Iterative Health tools including CTMS, EMR systems, and Salesforce.
• Experience working within a research site network or multi-site clinical trial environment.
• Knowledge of GCP guidelines and human subject research regulations.

How We Work 

• Collaborative and low-ego team environment
• High ownership and accountability culture
• Fast-paced and highly iterative growth environment
• Open communication and continuous learning mindset
• Mission-driven organization focused on improving patient outcomes
• Comfortable navigating evolving business priorities and opportunities