Bighat

37 Bighat Jobs Hiring Near You

Senior Software Engineer

San Mateo, CA · On-site

$198 - $215/hr

San Mateo, CA Description BigHat Biosciences is looking for a Senior Software Engineer to join our engineering team. This role is for experienced engineers ready to own a significant area of our ...

Senior Software Engineer

San Mateo, CA · On-site

$19K - $215K/mo

BigHat Biosciences is looking for a Senior Software Engineer to join our engineering team. This role is for experienced engineers ready to own a significant area of our platform as a subject-matter ...

Senior Software Engineer

San Mateo, CA · On-site

$139K - $184K/yr

BigHat Biosciences is looking for a Senior Software Engineer to join their engineering team. This role involves owning significant areas of the platform, leading projects end-to-end, and ...

Senior Software Engineer

San Mateo, CA · On-site

$140K - $184K/yr

BigHat Biosciences is looking for a Senior Software Engineer to join our engineering team. This role is for experienced engineers ready to own a significant area of our platform as a subject-matter ...

Senior Software Engineer

San Mateo, CA · On-site

$139K - $183K/yr

BigHat Biosciences is looking for a Senior Software Engineer to join our engineering team. This role is for experienced engineers ready to own a significant area of our platform as a subject-matter ...

What BigHat Offers: * Range of health insurance plan options through Anthem and Kaiser (monthly credit if benefit waived) * Dental, and vision coverage through Guardian * Additional well‑being ...

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Bighat Jobs Information

Infographic showing various job openings at Bighat in the United States as of August 2026, with employment types broken down into 100% Full Time. Highlights an 100% Physical job distribution.

Scientist II, Developability

BigHat Biosciences

San Mateo, CA

$145K - $165K/yr

Full-time

Medical, Dental, Vision, Retirement

Re-posted 27 days ago


Job description

The Role: BigHat Biosciences is looking for a hands-on, bench-driven scientist to drive antibody developability assessments that advance our Milliner Platform for AI-designed therapeutics. This is a primarily lab-based role where you'll spend the majority of your time at the bench executing and innovating on our developability workflows.
*At BigHat we believe in titles that commensurate with skill set, relative organizational impact, and value contribution; more experienced candidates are encouraged to apply, with the understanding that 
responsibilities and title would adjust as appropriate. 
  • Lead developability R&D projects: design, optimize, and execute high throughput developability assays to expand BigHat's toolkit.
  • Drive developability assessments (purity, stability, tolerability, biophysical properties) across programs, with strong attention to data interpretation and organization.
  • Support late-stage characterization and IND-enabling studies, including formulation screening, stress testing, peptide mapping, and simulated administration studies, to rank and advance lead candidates.
  • Serve as the Developability lead within project teams, guiding experimental strategy to address liabilities and hit program milestones.
  • Work cross-functionally to automate and train colleagues on new and existing methods, build QC frameworks for monitoring assay performance, and adapt workflows to existing LIMS infrastructure.
  • Proactively and independently analyze data, interpret scientific findings, propose next steps, and broadcast findings clearly across the organization.
  • PhD in Biochemistry or relevant discipline with 3+ year(s) of industry experience; exceptional non-PhD candidates with deep bench experience will be considered.
  • Strong background in biophysical and analytical characterization of antibodies and antibody fragments: SEC, HIC, CE-SDS, DLS, DSF, ELISA, LC-MS, including method development and optimization.
  • Track record of translating complex data into clear results and recommended actions.
  • Experience with protein structures and antibody engineering.
  • Enthusiastic about learning and onboarding new technologies to expand capabilities and improve work quality, timelines, throughput or cost.
  • Nice-to-haves include prior experience working in a dynamic start-up environment, working as a project lead, and working with automation. 
The salary estimated for this position is $145,000 - $165,000 + bonus + options + benefits. Compensation will vary depending on job-related knowledge, skills, and experience. Actual compensation will be confirmed in writing at the time of the offer.
What BigHat Offers:
  • Range of health insurance plan options through Anthem and Kaiser (monthly credit if benefit waived)
  • Dental, and vision coverage through Guardian
  • Additional well-being benefits through Nayya, OneMedical, Wagmo, Rula, and more
  • 401(k) with company match 
  • DTO, two weeks of company-wide shutdown, and 12 company holidays
  • Paid parental leave