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Alnylam Pharmaceuticals
Alnylam Pharmaceuticals

61 Alnylam Pharmaceuticals Process Development Engineer Jobs Hiring Near You

Validation & Engineering Group, Inc

PR · On-site

... Pharmaceutical, Biotechnology, Chemical, Food, and Medical Devices industries in the following ... The Process Development Engineer supports the development, validation, and implementation of new ...

Huntsman

Process Development Engineer

Los Angeles, CA · On-site

: Process Development Engineer Huntsman is seeking a Process Development Engineer supporting the Advanced Materials Division located in Los Angeles. This position will report to the Process Development ...

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Infographic showing various Process Development Engineer job openings at Alnylam Pharmaceuticals in the United States as of August 2026, with employment types broken down into 100% Full Time. Highlights an 52% Physical, and 48% Remote job distribution.

Director, Peptide Process Development

Alnylam Pharmaceuticals

Cambridge, MA • On-site

$197K - $266K/yr

Full-time

Medical, Dental, Vision, Life, Retirement, PTO

This job post has expired today. Applications are no longer accepted.

Job description

Overview:
The Director of Peptide & Peptide-Oligonucleotide Conjugate (POC) Process Development will provide technical leadership for the development, scale-up, and external manufacture of peptide and POC active pharmaceutical ingredients. This role is accountable for advancing robust, scalable, and regulatory-ready processes from early development through clinical and commercial supply.
This position requires a balance of hands-on technical expertise, strong CDMO management experience, and cross-functional leadership to deliver peptide and POC processes that are fit for development, manufacture, and future scale
This position is onsite and will be primarily located in Cambridge, MA.
Responsibilities:
  • Lead process development, optimization, scale up, and characterization of peptides and contribute to the development of peptide oligonucleotide conjugate (POC) APIs with internal stakeholders.
  • Serve as the technical lead for peptide and POC processes from development through external GMP manufacture.
  • Evaluate, select, and enable CDMOs; lead process transfer and external manufacturing activities.
  • Author and review technical and regulatory documentation supporting API manufacture and filings.
  • Integrate CMC process activities within TOQ and extended program teams.
  • Contribute to long-term peptide and POC platform strategy and delivery.

Qualifications:
  • PhD in a relevant scientific discipline with 10+ years of industry experience in peptide and/or conjugate process development.
  • Demonstrated expertise in peptide API development, scale up, and process characterization.
  • Experience in process development, optimization, scale-up, and process characterization of peptide-drug conjugates and/or oligonucleotide conjugates.
  • Proven experience leading process transfer and external CDMO-based GMP manufacturing.
  • Experience supporting CMC documentation and regulatory filings.
  • Ability to function as a technical owner within cross-functional program teams.

#LI-KB1 #LI-Onsite
U.S. Pay Range
$197,100.00 - $266,700.00
The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).
Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.
Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers
About Alnylam
We are the leader in RNAi therapeutics - a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another.
At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

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