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Company Description

About AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on LinkedIn, Facebook, Instagram, X and YouTube.

Job Description

We seek a Senior Scientist II, Analytical Development to join an experienced, fast-paced and collaborative team. This position will be primarily responsible for guiding the biophysical analytical strategy and developing novel analytical methods for characterizing AbbVie's mRNA-based targeted lipid nanoparticles (tLNPs) pipeline. This role will focus on developing novel biophysical methods for characterizing mRNA, lipids, and plasmids. Working collaboratively across discovery research, this position will develop novel characterization methods to support process/product understanding, expansion of the mRNA/tLNP platform and pipeline, and build structure-activity relationships.

Responsibilities & Duties:

• Develop novel biophysical methods to characterize mRNA drug substance, including but not limited to LC, CE, LC-MS, MALLS, mass photometry, and plate-based assays
• Improve plasmid characterization and build relationships to mRNA quality
• Support product characterization for tLNP platform/formulation development and lead candidate selection
• Lead mass-spec characterization of oligonucleotides, proteins, and lipids
• Support characterization of lipid content and related impurities
• Support implementation of automation/high throughput (HTP) workflows and in-process analytical methods for routine and non-routine testing
• Represent functional area in cross-functional pipeline and technology development teams
• Support method transfer and qualifications as needed
• Draft technical reports and documents as needed

Qualifications

• PhD with 4+ years related experience, Master's with 10+ years experience, or Bachelor's with 12+ years of experience
• Degree in Biochemistry, Chemistry, Bioengineering, Chemical Engineering or related field with proven technical and leadership track record developing analytical characterization methods for biologics (e.g. antibodies, mRNA, etc) is required
• Expertise with LC-MS is required
• Experience developing analytical methods for oligonucleotides (e.g. LC, CE, MS, MALLS, etc) and lipids is required. Experience with plasmid characterization is strongly preferred
• Experience with method transfer and qualification is preferred
• Strong proficiency authoring and reviewing technical reports
• Experience with stability and comparability studies is preferred
• Strong communication skills, both written and verbal, with a demonstrated capacity to thrive in collaborative, team-driven environments.

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: 

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future. 

• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.

• This job is eligible to participate in our short-term incentive programs. 

Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company's sole and absolute discretion, consistent with applicable law. 

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled. 

US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html

US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more:

https://www.abbvie.com/join-us/reasonable-accommodations.html