Work from home Excel professionals input data into a Microsoft Excel spreadsheet. This career is a remote position that you do if you work as a virtual assistant or focus specifically on data entry. You can also teach others how to use Excel or help businesses with their spreadsheet and organization needs. The responsibilities and duties you perform can include collecting data and inputting onto the worksheet, using the formula functions that are part of the program, doing analysis, and creating charts for your clients. You can choose to work for one employer or several individual clients.