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Variant Scientist Jobs in Massachusetts (NOW HIRING)

Ampersand

Senior Scientist I, Microfluidics

Boston, MA · On-site

$126 - $159.50/hr

The Role Ampersand Biomedicines is seeking a Senior Scientist I to help build and apply cell-based, high-throughput capabilities for engineered antibody and protein variant library screening. This ...

Novartis

Human Genetics Laboratory Leader

Cambridge, MA · On-site

$152K - $283K/yr

... variant genetics, functional biology, and advanced analytical approaches to inform target prioritization. This position is part of the Human Genetics & Targets group within the Discovery Sciences ...

Waters Corporation

Senior SAP VC AVC Modeler

Milford, MA · On-site

... variant configuration models in SAP S/4HANA that enable accurate product quoting in SAP CPQ. This ... Bachelor's degree in Engineering, Computer Science, Information Systems, or related field. * 5+ ...

Prattwhitney

SPY-6(V)4 Chief Engineer (CE)

Sudbury, MA · On-site

$157 - $299/hr

Together, we push the boundaries of known science and find new ways to connect and protect our ... This (V)4 variant is part of the SPY‑6 Family of Radars (FoRs) being produced by Raytheon on the ...

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Variant Scientist information

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How much do variant scientist jobs pay per hour?

As of Aug 30, 2026, the average hourly pay for variant scientist in Massachusetts is $50.48, according to ZipRecruiter salary data. Most workers in this role earn between $36.62 and $63.95 per hour, depending on experience, location, and employer.

What is a variant scientist?

Variant Scientists are professionals who analyze genetic variants—differences in DNA sequences—to determine their significance in health and disease. They interpret genomic data, often from whole-genome or exome sequencing, to assess whether specific variants may cause or contribute to medical conditions. Their work is crucial in clinical genetics, precision medicine, and biomedical research, helping guide patient diagnosis and treatment. Variant Scientists collaborate with clinicians, bioinformaticians, and laboratory personnel to provide accurate and actionable genetic insights.

What does a variant scientist do?

As a variant scientist, you work for a research laboratory in a university or a medical facility to test and study variations of genes and the effects they have on human development. As part of your duties, you aid in the development of new tests to discover gene abnormalities, perform analysis on patient samples to identify possible mutations, and record your findings to assist in scientific research. You also have heavy reporting responsibilities that may require in-depth computer and writing skills, the ability to analyze data, and strong attention to detail. In this role, you may cater to a specific health field, like pediatrics or oncology.

What are the key skills and qualifications needed to thrive as a variant scientist, and why are they important?

To thrive as a Variant Scientist, you need a solid background in genetics, molecular biology, and bioinformatics, typically supported by an advanced degree such as a PhD or MSc in a related field. Familiarity with next-generation sequencing (NGS) platforms, variant annotation tools, and data analysis software like GATK or ANNOVAR is essential. Strong analytical thinking, attention to detail, and effective communication skills help you interpret complex genetic data and collaborate with multidisciplinary teams. These skills ensure accurate variant interpretation, drive discoveries, and support precision medicine initiatives.

What are some common challenges faced by variant scientists in interpreting genetic data, and how are these typically addressed within a team?

Variant Scientists often encounter challenges such as distinguishing between benign and pathogenic variants, managing large volumes of sequencing data, and staying updated with rapidly evolving genetic databases. These challenges are typically addressed by collaborating closely with bioinformaticians, clinical geneticists, and laboratory personnel to review findings and validate interpretations. Regular team meetings, use of standardized classification guidelines like ACMG, and leveraging advanced software tools help ensure accurate and consistent variant analysis.
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Variant Scientist jobs near you
Infographic showing various Variant Scientist job openings in Massachusetts as of August 2026, with employment types broken down into 86% Full Time, 11% Part Time, and 3% Contract. Highlights an 94% In-person, and 6% Remote job distribution, with an average salary of $104,990 per year, or $50.5 per hour.

Clinical Genomics Specialist II, ClinGen Biocurator

Cambridge, MA • On-site

Broad Institute
1 - 5K employees
Learn more about Broad Instituteexternal

$70K - $94K/yr

Full-time

Medical, Dental, Vision, Life, Retirement, PTO

Posted 3 days ago

New

Job description

General information
Location
Cambridge, MA
Ref #
44744
Job Family
Research
Workplace
Hybrid
Date published
08/25/2026
Time Type
Full time
Pay Range
$70,000.00/yr - $94,000.00/yr
Description & Requirements
Clinical Genomics Specialist - ClinGen team
We are seeking a motivated individual to work in a cutting-edge environment at the Broad Institute to serve as a clinical genomics specialist/biocurator for the Clinical Genome Resource (ClinGen). ClinGen is an NIH-funded program that is building authoritative resources to define the clinical relevance of genes and variants for use in precision medicine and research. This position would work closely with multiple ClinGen Expert Panels (EPs) working on classifying genes and variants for their role in disease. The role would involve direct biocuration as well as mentoring of research associates that support biocuration for the ClinGen EPs to ensure accurate usage of ClinGen rules and approaches as well as rigorous evaluation of evidence. The role would begin with training within our variant and gene-curation team (which supports variant classification and gene-disease validity assessment). Once trained, the individual would support an array of ClinGen disease-specific Expert Panel activities and affiliated projects within ClinGen and at the Broad Institute.
PRINCIPAL DUTIES AND RESPONSIBILITIES
Support ClinGen curation activities
  • Act as the scientific lead for expert panels, leading them through curations and variant research.
  • Research the significance of variants and genes through literature and data review
  • Accurately classifies variant- and gene-disease relationships
  • Contribute to research projects that require curation of genomic knowledge
  • Mentor junior biocurators
  • Assist in the development and maintenance of training materials for internal and external ClinGen curators

Support ClinGen's mission to provide better access to genomic data
  • Support the sharing of curated knowledge with the community
  • Assist laboratories with data submission to ClinVar (www.ncbi.nlm.nih.gov/clinvar)
  • Collect data from locus-specific databases to deposit into ClinVar
  • Assist in the development of software tools for supporting variant and gene curation
  • Assist in resolving variant interpretation differences between ClinVar submitters
  • Support the writing of ClinGen research publications
  • Present at national meetings

The TGG supports the use of genomics in medicine, by focusing on community-centered projects that promote collaboration, data sharing and open science. The TGG is led by Heidi Rehm and consists of high-impact projects such as the Center for Mendelian Genomics co-led by Anne O'Donnell-Luria and the gnomAD project co-led by Mark Daly.
Start date: ASAP or by October 2026 with a minimum of a two-year commitment.
Qualifications: Master's in variant science, genetic counseling, or another relevant field required; Experience with rare disease gene and variant interpretation preferred
Job locations: 300 Binney, Cambridge, MA
This role will be a hybrid position with an expectation of a minimum of 2-3 days physically in the office.
Reports to: Marina DiStefano, PhD, FACMG, Director of Clinical Genomic Operations, BCL, Director of ClinGen Biocurator Core at Broad Institute
The expected base pay range for this position as listed above is based on a 40 hour per week schedule. Broad provides pay ranges representing its reasonable and good faith estimate of what the organization reasonably expects to pay for a position at the time of posting. Actual compensation will vary based on factors including but not limited to, relevant skills, experience, education, qualifications, and other factors permissible by law.
At Broad, your base pay is just one part of a comprehensive total rewards package. From day one, this role offers a competitive benefits package including medical, dental, vision, life, and disability insurance; a 401(k) retirement plan; flexible spending and health savings accounts; at least 13 paid holidays; winter closure; paid time off; parental and family care leave; and an employee assistance program, among other Broad benefits.
The Broad Institute is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, national origin, religion, age, color, sex, disability, protected veteran status, or any other characteristic protected by local, state, or federal laws, rules, or regulations.
Should you need a reasonable accommodation to complete the application or interview process, please contact recruiting@broadinstitute.org for assistance.

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