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Upstream Process Jobs in Boston, MA (NOW HIRING)

Biopharma Careers

Principal Scientist

Waltham, MA · On-site

Demonstrate expertise in upstream process operations at all scales. * Lead root‑cause analysis (RCA) investigations for process deviations, equipment failures at pilot scale. * Present findings and ...

Sartorius

Process Technology Engineer

Marlborough, MA · On-site

R40424Join Sartorius as a Process Technology Engineer, supporting upstream and downstream bioprocess solutions across the full project lifecycle--from customer discovery through project execution.

Sartorius AG

Process Technology Engineer

Marlborough, MA · On-site

$95K - $120K/yr

Join Sartorius as a Process Technology Engineer, supporting upstream and downstream bioprocess solutions across the full project lifecycle-from customer discovery through project execution. You will ...

Amgen

Process Development Associate

Cambridge, MA · On-site

Process Development Associate What you will do Let's do this. Let's change the world. In this vital ... Perform small-scale bioprocess experiments that encompass both upstream (cell culture) and ...

Tech Etch

Automation Engineering Director

Plymouth, MA · On-site

... upstream process variation through the application of Lean and Six Sigma methodologies, ensuring manufacturing processes are stable, capable, and standardized in support of automation solutions that ...

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Upstream Process information

See Boston, MA salary details

$15

$27

$52

How much do upstream process jobs pay per hour?

As of Sep 11, 2026, the average hourly pay for upstream process in Boston, MA is $27.68, according to ZipRecruiter salary data. Most workers in this role earn between $19.09 and $32.12 per hour, depending on experience, location, and employer.

What cities near Boston, MA are hiring for Upstream Process jobs?

Cities near Boston, MA with the most Upstream Process job openings:

Upstream Process jobs near you

Head of Cell Line Development

Cambridge, MA • On-site

Scorpion Therapeutics
51 - 200 employees
Learn more about Scorpion Therapeuticsexternal

Other

Posted 12 days ago

Job description

Head of Cell Line Development (Director)Responsibilities:
  • Define CLD vision, platform strategy, and roadmap aligned to portfolio demand.
  • Lead, coach, and develop a team (~10) for clinical cell line delivery and technology evaluation.
  • Own functional budget, cell line timelines, and vendor governance (CRO/CDMO support as needed).
  • Provide end-to-end oversight of mammalian cell line development: vector/transfection strategy, selection systems, single-cell cloning, clone screening, stability assessment, and nomination.
  • Ensure fit-for-purpose characterization packages (growth, productivity, stability, product quality) with upstream process development.
  • Lead risk-based strategies for difficult-to-express/complex molecules (e.g., bi-specifics).
  • Ensure robust documentation (cell line history, clonality rationale, traceability, data integrity) to support filings/audits; contribute to IND/IMPD submissions.
  • Accountable for cell banking strategy/execution, including GMP readiness for MCB/WCB generation and compliant handoffs/documentation.
  • Evaluate and implement new CLD technologies (host cell/selection systems, single-cell tools, automation, analytics, digital/AI-enabled screening) and ensure platform fit.
  • Build external collaborations with technology providers and academic/industry partners.
Qualifications:
  • Recognized expert in Cell Line Development with a track record delivering clinical production cell lines and strong tech transfer packages.
  • Deep expertise in cell biology, host cell engineering, and expression vector design.
  • Strong understanding of CLD impact on product quality/manufacturability (esp. bi-specifics/complex proteins).
  • Expert in influencing; manage in a matrix environment; collaborate cross-functionally with senior stakeholder communication.
  • Extensive experience leading/coaching scientists and driving career development.
  • Experience supporting commercial cell lines and lifecycle management (investigations, comparability/change control) including regulatory/quality requirements for MCB/WCB and IND/BLA.
  • Demonstrated success with automation/high-throughput screening and improving cycle times.
  • Expert troubleshooting; solves strategic problems and coaches others.
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