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Technical Operations Scientist Jobs in Delaware (NOW HIRING)

Iff

AI & Data Scientist

Wilmington, DE

Job Summary Are you passionate about using AI, data science and digital innovation to transform ... technical operations. * Perform statistical analyses to identify trends, deviations and ...

US Tech Solutions

Senior Scientist

Wilmington, DE · On-site

$88K - $121K/yr

The Senior Scientist role is responsible for aiding in the supply of strategic drug product ... Operations. Support manufacturing and supply chain changes: -Perform technical risk assessments for ...

PSG Global Solutions

Scientist

Newark, DE · On-site

... operations. The Company also provides staffing services through its franchised Management ... Obtains, correlates, and analyzes technical information needed to accomplish routine tasks.

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Technical Operations Scientist information

What is a technical operations scientist?

Technical Operations Scientists are professionals who bridge the gap between scientific research and operational processes in industries such as pharmaceuticals, biotechnology, or manufacturing. They focus on ensuring that scientific procedures are efficiently translated into scalable production systems, maintaining product quality and compliance. Their responsibilities often include troubleshooting process issues, optimizing workflows, supporting technology transfer, and liaising between research, development, and production teams. This role is critical for maintaining seamless operations and supporting continuous improvement in technical environments.

What are some typical challenges technical operations scientists face when transitioning from research-focused roles?

Technical Operations Scientists often encounter challenges when shifting from research to operations, such as adapting to a faster-paced environment with strict timelines and regulatory requirements. Unlike pure research roles, this position emphasizes process optimization, troubleshooting, and cross-functional collaboration with manufacturing, quality assurance, and engineering teams. Success often depends on strong communication skills, attention to detail, and the ability to quickly resolve issues to maintain seamless production. Embracing these new responsibilities can offer valuable career growth and exposure to large-scale product development.

What are the key skills and qualifications needed to thrive as a technical operations scientist, and why are they important?

To thrive as a Technical Operations Scientist, you need a strong background in life sciences or engineering, analytical problem-solving abilities, and relevant industry experience, often supported by a bachelor’s or master’s degree. Familiarity with laboratory information management systems (LIMS), process validation, and quality control tools is typically required, along with knowledge of regulatory standards such as GMP. Strong communication, attention to detail, and teamwork skills help you collaborate effectively and troubleshoot complex operational issues. These competencies ensure processes run smoothly, products meet quality standards, and regulatory compliance is maintained in a high-stakes technical environment.

What is the difference between Technical Operations Scientist vs Laboratory Scientist?

AspectTechnical Operations ScientistLaboratory Scientist
CredentialsBachelor's or Master's in Life Sciences, Chemistry, or related fields; often requires technical certificationsBachelor's or Master's in Life Sciences, Chemistry, or related fields; certifications vary by specialization
Work EnvironmentManufacturing facilities, biotech companies, or research labs focusing on process optimization and technical supportResearch labs, clinical labs, or academic settings conducting experiments and analyses
Employer & Industry UsageBiotech, pharmaceutical, and manufacturing industries; involved in technical operations and process troubleshootingAcademic, clinical, or research institutions; focused on experimental work and data collection

The Technical Operations Scientist and Laboratory Scientist roles share educational backgrounds and work in scientific environments. However, the Technical Operations Scientist emphasizes process support, technical troubleshooting, and manufacturing operations, while the Laboratory Scientist focuses on experimental research and data analysis. Both roles are essential in biotech and pharma industries but serve different functions within the research and production pipeline.

What are popular job titles related to Technical Operations Scientist jobs in Delaware?

For Technical Operations Scientist jobs in Delaware, the most frequently searched job titles are:

What job categories do people searching Technical Operations Scientist jobs in Delaware look for?

The top searched job categories for Technical Operations Scientist jobs in Delaware are:

What cities in Delaware are hiring for Technical Operations Scientist jobs?

Cities in Delaware with the most Technical Operations Scientist job openings:

Technical Operations Scientist jobs near you
Infographic showing various Technical Operations Scientist job openings in Delaware as of August 2026, with employment types broken down into 86% Full Time, 13% Part Time, and 1% Contract. Highlights an 93% Physical, 3% Hybrid, and 4% Remote job distribution.

Downstream Operations Scientist

Newark, DE • On-site

University of Delaware
Colleges, Universities, and Professional Schools • 1 - 5K employees

5.7

Company rating: 5.7 out of 10

Based on 21 frontline employees who took The Breakroom Quiz

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Learn more about University of Delawareexternal

Full-time

Re-posted 19 days ago

Job description

Downstream Operations Scientist
Job no: 502528
College / VP Area: Research Office
Work type: Staff
Location: Newark, DE
Categories: Research & Laboratory, Full Time
Pay Grade: 33E
Context of the Job:
NIIMBL (the National Institute for Innovation in Manufacturing Biopharmaceuticals) is the largest industry-led public-private partnership dedicated to biopharmaceutical manufacturing innovation with participation from well-over 200 companies, government agencies, and other partners collectively innovating manufacturing approaches. As part of these activities, NIIMBL is home to a technical operations team that works collaboratively with scientists from across the biopharmaceutical manufacturing industry including manufacturers, suppliers, and government agencies. The Downstream Operations Scientist is responsible for leading downstream purification unit operations in NIIMBL's continuous mAb purification process that is part of a Process Intensification program. The work will involve 21CFR58 compliant downstream operations and data analysis, including utilizing automation systems. The scientist will also collaborate with bioreactor specialists and an analytical team, and have access to state-of-the-art knowledge from across the industry and government in guiding the work.
NIIMBL's extensive portfolio of research, development, demonstration, and innovation activities is funded by federal, private, state, and other sources with the parent sponsoring government agency being the National Institute of Standards and Technology (NIST). NIIMBL is also a member of the Manufacturing USA network of institutes, a multi-billion dollar investment by the federal government to advance United States competitiveness in advanced manufacturing innovation. Institutionally at the University of Delaware, NIIMBL reports to the Vice President for Research, Scholarship & Innovation.
Among other activities, NIIMBL executes technical projects that advance the readiness levels of relevant technologies, assays, and methods. The scopes of scientific projects generally include many organizations as partners and collaborators such as scientists from several large and small companies, a scientist from a federal agency, and a scientist from a university. Many of these projects will be hosted at the University of Delaware in a state-of-the-art laboratory facility purpose-built for such studies. These projects will involve a diverse set of technologies and approaches and address drug substance, drug product, and analytical needs by the industry appropriate to several types of biopharmaceuticals: therapeutic antibodies and proteins , gene therapy vectors, vaccines, antibody-drug conjugates, bispecific antibodies, and cell therapies, among others.
Major Responsibilities
  • Demonstrate NIIMBL's Core Values in daily conduct and ensures all decisions, actions, and teamwork practices align with the organization's Business Principles.
  • Serve as a lead technical scientist on multiple projects involving downstream purification unit operations for the manufacture of industrially relevant products and related activities.
  • Evaluate and introduce new technologies and analytical tools to existing processes.
  • Adhere to 21CFR58 GxP guidelines in execution of work.
  • Set-up, operate, troubleshoot, maintain, and clean downstream bioprocessing equipment.
  • Use manufacturing experience to identify process parameters and define their setpoints.
  • Perform DoE studies to confirm the impact of process parameters on impurity levels, product recovery, and potency.
  • Characterize performance of existing purification and formulation unit operations, including column chromatography (e.g., ProA, SEC, CEX, AEX), filtration, TFF, and bulk filling.
  • Develop new filtration unit operations such as tangential-flow filtration (TFF), virus filtration, and depth filtration.
  • Develop new chromatography unit operations, from screening and characterization to optimization and initial scale-up.
  • Optimize buffer compositions to improve the stability and solubility of target molecules.
  • Collaborate with an analytical team to adapt and troubleshoot research analytical methods such as HPLC, SDS-PAGE, enzyme activity and endotoxin assays to quantify yield, activity, and purity at various stages of the manufacturing process.
  • Document all work and analyses in an electronic lab notebook. Perform tracking and trend analysis of method performance.
  • Analyze process performance trends, perform statistical data analysis, and present data to teams.
  • Partner with Informatics Infrastructure team on deploying structured data capture systems.
  • Draft and revise SOPs and batch records.
  • Maintain detailed documentation of lab activities and tabulation of data.
  • Compile data generated to present and discuss at team meetings.
  • Author, review and edit technical reports and manuscripts intended for publication.
  • Stay current with relevant technologies and scientific literature.
  • Perform other job-related duties as assigned.

Qualifications:
  • A Masters and 5+ years or PhD and 2+ years in chemical engineering or relevant life science discipline.
  • Industrially relevant downstream purification experience is required with preference for experience in a 21CFR58-compliant GxP environment.
  • Hands-on experience with a range of downstream unit operations and control systems, experience with DeltaV preferred.
  • Operates chromatography skids and other bioprocess equipment for purification of industrially relevant materials.
  • Knowledge of biotech manufacturing process and equipment including depth and tangential flow filtration, column chromatography, protein purification and formulation and/or buffer and media operations.
  • Possess a contribution mindset fueled by an inner drive to take initiative without being directed.
  • Excellent interpersonal and managing skills with the desire to work collaboratively and effectively in a team environment.
  • Ability to demonstrate effective leadership through communication, respect, influence, persuasion, and trust.
  • Excellent problem solving and critical thinking skills.
  • Excellent writing, communication, and presentation skills.
  • Strong MS Excel, PowerPoint, and Word skills. Microsoft Project skills.
  • Excellent organization and planning skills.
  • Strong attention to detail and ability to adhere to standards procedures.
  • Ability to function in a rapidly changing environment.

Notice of Non-Discrimination and Equal Opportunity
The University of Delaware does not discriminate against any person on the basis of race, color, national origin, sex, gender identity or expression, sexual orientation, genetic information, marital status, disability, religion, age, veteran status or any other characteristic protected by applicable law in its employment, educational programs and activities, admissions policies, and scholarship and loan programs as required by Title IX of the Educational Amendments of 1972, the Americans with Disabilities Act of 1990, Section 504 of the Rehabilitation Act of 1973, Title VI and VII of the Civil Rights Act of 1964, and other applicable statutes and University policies. The University of Delaware also prohibits unlawful harassment including sexual harassment and sexual violence.
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