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Structural Biologist Jobs in Gaithersburg, MD (NOW HIRING)

Guidehouse

Molecular Biologist

Bethesda, MD · On-site

$74K - $124K/yr

We are looking for a Molecular Biologist (Virology Core Biological Scientist) to support the ... Ability to support data visualization and structural modeling for scientific communication. The ...

Umd

Post-Doctoral Associate

College Park, MD · On-site

$62K - $75K/yr

Prior experience in structural biology, immunology, and/or virology is preferred but not required. Additional Job Details Required Application Materials: 1) Cover letter 2) CV 3) List of references ...

Axle

Bioinformatics Scientist

Bethesda, MD · On-site

Contribute to the development of a scalable and flexible resource to provide NGS bioinformatics, structural biological and computational, machine learning data support to NIAID scientists and ...

Axle

Bioinformatics Scientist

Bethesda, MD · On-site

Contribute to the development of a scalable and flexible resource to provide NGS bioinformatics, structural biological and computational, machine learning data support to NIAID scientists and ...

Axle

Bioinformatics Scientist

Bethesda, MD · On-site

Contribute to the development of a scalable and flexible resource to provide NGS bioinformatics, structural biological and computational, machine learning data support to NIAID scientists and ...

Leidos

Senior Civil Engineer - TS/SCI Poly Required

Reston, VA · On-site

$108K - $149K/yr

... structural engineering within commercial, Department of Defense, or Intelligence Community environments. * Industrial & Facility Focus: Proven experience analyzing chemical, nuclear, or biological ...

Leidos

Senior Civil Engineer - TS/SCI Poly Required

Reston, VA · On-site

$108K - $149K/yr

... structural engineering within commercial, Department of Defense, or Intelligence Community environments. * Industrial & Facility Focus: Proven experience analyzing chemical, nuclear, or biological ...

Meso Scale Discovery

Scientist

Gaithersburg, MD · On-site

$101K - $154K/yr

... OR structural biology and membrane protein experience highly desirable. o Supervisory/management experience desired. • A strong publication record desired. KNOWLEDGE, SKILLS AND ABILITIES: • ...

MSD

Scientist

Gaithersburg, MD · On-site

$101K - $154K/yr

... OR structural biology and membrane protein experience highly desirable. o Supervisory/management experience desired. • A strong publication record desired. KNOWLEDGE, SKILLS AND ABILITIES: • ...

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Structural Biologist information

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How much do structural biologist jobs pay per hour?

As of Aug 29, 2026, the average hourly pay for structural biologist in Gaithersburg, MD is $38.37, according to ZipRecruiter salary data. Most workers in this role earn between $31.44 and $43.65 per hour, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive as a structural biologist?

To thrive as a Structural Biologist, you need a strong background in molecular biology, biochemistry, and protein chemistry, usually supported by a PhD in a relevant field. Proficiency with techniques such as X-ray crystallography, cryo-electron microscopy (cryo-EM), and computational modeling software is typically required. Strong analytical thinking, attention to detail, and effective teamwork are critical soft skills for interpreting complex data and collaborating on research projects. These skills are essential for accurately elucidating biomolecular structures, advancing scientific knowledge, and driving innovation in drug discovery and biotechnology.

What are some common challenges structural biologists face when collaborating on interdisciplinary research projects?

Structural biologists often work closely with computational scientists, chemists, and clinicians to interpret and apply structural data. A common challenge in these collaborations is effectively communicating complex structural information to colleagues outside the field, ensuring that findings are accurately understood and integrated into broader research goals. Additionally, coordinating project timelines and data sharing across diverse teams can require strong organizational skills and adaptability. Building mutual understanding and setting clear expectations at the outset can help overcome these challenges and foster productive interdisciplinary work.

What is the difference between Structural Biologist vs Molecular Biologist?

AspectStructural BiologistMolecular Biologist
Required CredentialsTypically a Ph.D. in biochemistry, biophysics, or related fieldsUsually a Ph.D. or Master's in biology, biochemistry, or related areas
Work EnvironmentResearch labs, universities, biotech companies focusing on 3D structuresLabs, research institutions, focusing on gene and protein functions
Employer & Industry UsagePharmaceuticals, biotech, academia, structural research

While both roles involve biological research, Structural Biologists specialize in determining the 3D structures of biomolecules, often using techniques like X-ray crystallography or cryo-EM. Molecular Biologists focus on understanding gene and protein functions at the molecular level. The two roles often overlap but differ mainly in their focus and methods used.

How much does a structural biologist make?

A structural biologist's salary varies based on experience, education, and location, but typically ranges from $60,000 to $120,000 annually. Entry-level positions may start lower, while experienced professionals with advanced skills in techniques like X-ray crystallography or cryo-EM can earn higher salaries, especially in research or industry settings.

Is structural biology in demand?

Structural biologists are in demand in research institutions, pharmaceutical companies, and biotech firms, as their expertise in techniques like X-ray crystallography and cryo-electron microscopy is essential for drug development and understanding biological mechanisms. The field offers opportunities for employment with advanced degrees and proficiency in specialized tools. Growing interest in personalized medicine and structural analysis continues to drive job opportunities in this area.

What does a structural biologist do?

A structural biologist studies the 3D structures of biological molecules such as proteins, nucleic acids, and complexes using techniques like X-ray crystallography, NMR spectroscopy, and cryo-electron microscopy. Their work helps understand how these molecules function and interact, which can inform drug design and disease research. They often work in research labs, collaborating with chemists and biologists, and require strong skills in biochemistry and molecular biology.
Structural Biologist jobs near you
Infographic showing various Structural Biologist job openings in Gaithersburg, MD as of August 2026, with employment types broken down into 83% Full Time, 12% Part Time, 4% Contract, and 1% Nights. Highlights an 85% Physical, 4% Hybrid, and 11% Remote job distribution, with an average salary of $79,809 per year, or $38.4 per hour.

Structural Biology Research Scientist

Guidehouse

Bethesda, MD • On-site

$85K - $141K/yr

Full-time

Medical, Dental, Vision, Life, Retirement

Re-posted 29 days ago

Guidehouse rating

8.0

Company rating: 8.0 out of 10

Based on 28 frontline employees who took The Breakroom Quiz

35th of 72 rated business consultants

Job description

Job Family:

Biologist


Travel Required:

None


Clearance Required:

Ability to Obtain Public Trust

What You Will Do:
We are seeking a Structural Biology Research Scientist to supportthe National Institute of Allergy and Infectious Diseases (NIAID)through viral protein construct design, expression optimization, protein purification, and cryo-electron microscopy studies that advance vaccine development. Ideal candidates will bring structural virology experience and skills in assay development, data analysis, reporting, and mentorship.This is a full-time, on-site opportunity in Bethesda, MD.

Responsibilities:

  • Design and generate expression constructs for viral proteins (e.g., envelope glycoproteins, capsid proteins, regulatory proteins).

  • Develop andoptimizeexpression systems (mammalian, insect, or stable cell lines).

  • Purify proteins using chromatography methods (affinity, SEC, ion exchange).

  • Perform binding and antigenicity assays (e.g., ELISA, BLI, SPR)

  • Conduct biochemical and biophysical characterization (e.g., SEC-MALS, DLS)

  • Prepare samples and optimize vitrification conditions for cryo-EM studies

  • Operate and/or coordinate use of cryo-EM instruments (e.g., Titan Krios, Glacios)

  • Prepare technical reports, figures, and manuscripts


What You Will Need:

  • PhD in Structural Biology or a related field

  • Microsoft Office

  • Technical experience needed to assist in studying the basic principles of plant and animal life.

  • Technical support and troubleshooting of sophisticated equipment.

  • At least 2 (two) years of experience

  • Must be able to obtain and maintain a Federal or DoD "public trust"; candidates must obtain approved adjudication of their public trust prior to onboarding with Guidehouse. Candidates with an active public trust or suitability are preferred

What Would Be Nice To Have:

  • Previous experience supporting NIH

The annual salary range for this position is $85,000.00-$141,000.00. Compensation decisions depend on a wide range of factors, including but not limited to skill sets, experience and training, security clearances, licensure and certifications, and other business and organizational needs.


What We Offer:

Guidehouse offers a comprehensive, total rewards package that includes competitive compensation and a flexible benefits package that reflects our commitment to creating a diverse and supportive workplace.

Benefits include:

  • Medical, Rx, Dental & Vision Insurance

  • Personal and Family Sick Time & Company Paid Holidays

  • Parental Leave

  • 401(k) Retirement Plan

  • Group Term Life and Travel Assistance

  • Voluntary Life and AD&D Insurance

  • Health Savings Account, Health Care & Dependent Care Flexible Spending Accounts

  • Transit and Parking Commuter Benefits

  • Short-Term & Long-Term Disability

  • Tuition Reimbursement, Personal Development, Certifications & Learning Opportunities

  • Employee Referral Program

  • Corporate Sponsored Events & Community Outreach

  • Care.com annual membership

  • Employee Assistance Program

  • Supplemental Benefits via Corestream (Critical Care, Hospital Indemnity, Accident Insurance, Legal Assistance and ID theft protection, etc.)

  • Position may be eligible for a discretionary variable incentive bonus

About Guidehouse

Guidehouse is an Equal Opportunity Employer-Protected Veterans, Individuals with Disabilities or any other basis protected by law, ordinance, or regulation.

Guidehouse will consider for employment qualified applicants with criminal histories in a manner consistent with the requirements of applicable law or ordinance including the Fair Chance Ordinance of Los Angeles and San Francisco.

If you have visited our website for information about employment opportunities, or to apply for a position, and you require an accommodation, please contact Guidehouse Recruiting at 1-571-633-1711 or via email at RecruitingAccommodation@guidehouse.com. All information you provide will be kept confidential and will be used only to the extent required to provide needed reasonable accommodation.

All communication regarding recruitment for a Guidehouse position will be sent from Guidehouse email domains including @guidehouse.com or guidehouse@myworkday.com. Correspondence received by an applicant from any other domain should be considered unauthorized and will not be honored by Guidehouse. Note that Guidehouse will never charge a fee or require a money transfer at any stage of the recruitment process and does not collect fees from educational institutions for participation in a recruitment event. Never provide your banking information to a third party purporting to need that information to proceed in the hiring process.

If any person or organization demands money related to a job opportunity with Guidehouse, please report the matter to Guidehouse's Ethics Hotline. If you want to check the validity of correspondence you have received, please contact recruiting@guidehouse.com. Guidehouse is not responsible for losses incurred (monetary or otherwise) from an applicant's dealings with unauthorized third parties.

Guidehouse does not accept unsolicited resumes through or from search firms or staffing agencies. All unsolicited resumes will be considered the property of Guidehouse and Guidehouse will not be obligated to pay a placement fee.

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