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Structural Biologist Jobs in California (NOW HIRING)

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Structural Biologist information

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$18

$35

$49

How much do structural biologist jobs pay per hour?

As of Aug 22, 2026, the average hourly pay for structural biologist in California is $35.05, according to ZipRecruiter salary data. Most workers in this role earn between $28.70 and $39.86 per hour, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive as a structural biologist?

To thrive as a Structural Biologist, you need a strong background in molecular biology, biochemistry, and protein chemistry, usually supported by a PhD in a relevant field. Proficiency with techniques such as X-ray crystallography, cryo-electron microscopy (cryo-EM), and computational modeling software is typically required. Strong analytical thinking, attention to detail, and effective teamwork are critical soft skills for interpreting complex data and collaborating on research projects. These skills are essential for accurately elucidating biomolecular structures, advancing scientific knowledge, and driving innovation in drug discovery and biotechnology.

What are some common challenges structural biologists face when collaborating on interdisciplinary research projects?

Structural biologists often work closely with computational scientists, chemists, and clinicians to interpret and apply structural data. A common challenge in these collaborations is effectively communicating complex structural information to colleagues outside the field, ensuring that findings are accurately understood and integrated into broader research goals. Additionally, coordinating project timelines and data sharing across diverse teams can require strong organizational skills and adaptability. Building mutual understanding and setting clear expectations at the outset can help overcome these challenges and foster productive interdisciplinary work.

What is the difference between Structural Biologist vs Molecular Biologist?

AspectStructural BiologistMolecular Biologist
Required CredentialsTypically a Ph.D. in biochemistry, biophysics, or related fieldsUsually a Ph.D. or Master's in biology, biochemistry, or related areas
Work EnvironmentResearch labs, universities, biotech companies focusing on 3D structuresLabs, research institutions, focusing on gene and protein functions
Employer & Industry UsagePharmaceuticals, biotech, academia, structural research

While both roles involve biological research, Structural Biologists specialize in determining the 3D structures of biomolecules, often using techniques like X-ray crystallography or cryo-EM. Molecular Biologists focus on understanding gene and protein functions at the molecular level. The two roles often overlap but differ mainly in their focus and methods used.

How much does a structural biologist make?

A structural biologist's salary varies based on experience, education, and location, but typically ranges from $60,000 to $120,000 annually. Entry-level positions may start lower, while experienced professionals with advanced skills in techniques like X-ray crystallography or cryo-EM can earn higher salaries, especially in research or industry settings.

Is structural biology in demand?

Structural biologists are in demand in research institutions, pharmaceutical companies, and biotech firms, as their expertise in techniques like X-ray crystallography and cryo-electron microscopy is essential for drug development and understanding biological mechanisms. The field offers opportunities for employment with advanced degrees and proficiency in specialized tools. Growing interest in personalized medicine and structural analysis continues to drive job opportunities in this area.

What does a structural biologist do?

A structural biologist studies the 3D structures of biological molecules such as proteins, nucleic acids, and complexes using techniques like X-ray crystallography, NMR spectroscopy, and cryo-electron microscopy. Their work helps understand how these molecules function and interact, which can inform drug design and disease research. They often work in research labs, collaborating with chemists and biologists, and require strong skills in biochemistry and molecular biology.
Infographic showing various Structural Biologist job openings in California as of August 2026, with employment types broken down into 91% Full Time, 6% Part Time, 2% Contract, and 1% Nights. Highlights an 88% Physical, 3% Hybrid, and 9% Remote job distribution, with an average salary of $72,899 per year, or $35 per hour.

Open Application for Scientists and Research Associates

Rezo

San Francisco, CA โ€ข On-site

Other

Medical, Dental, Vision, Retirement

This job post hasย expired today.ย Applications are no longer accepted.


Job description

About Rezo Therapeutics

Rezo is a different kind of biopharma company. Our mission is to dramatically increase the success rate of drug development by building a diseaseโ€‘agnostic, fullyโ€‘integrated, network biology platform that will redefine our understanding of human disease and ability to treat it.

We are leveraging a unique integrated approach, combining capabilities in genetics, proteomics, structural biology and AI to generate deep biological insights and novel therapeutic approaches.

Located in San Franciscoโ€™s vibrant Mission Bay neighborhood, Rezo is in close proximity to UCSF, numerous urban amenities, and outdoor recreational opportunities. We recognize that realizing our mission depends as much on our people as it does on our science and are building a workplace that fosters collaboration, respect, and diversity where contributing to your teamโ€™s success is valued as highly as individual achievements. If youโ€™re passionate about team science and breaking down barriers to progress in drug development, please consider joining us!

If you do not see a job listing that matches your specific background, please apply to this posting as we will be looking for exceptional individuals in the following areas:

Proteomics
  • Develop industry scale assays using in-house mass spectrometers
  • Execute platform projects centered on PPI mapping, proximity labeling, postโ€‘translational modification and abundance proteomics
  • Support drug discovery campaigns and develop targetโ€‘based screens
Genetics
  • Develop multimodal single and combinatorial genetic screens using CRISPR technologies
  • Collaborate with target discovery teams to provide genetic support for targets and drug MOA
Chemical Biology and Protein Sciences
  • Develop HTS small molecule screening campaigns and create robust target assays for drug development
  • Drive enzymology, biophysics and protein binding analysis efforts
  • Help build out the structural biology platform (including crystallography & Cryoโ€‘EM)
  • Develop chemical biology tools to map ligandable pockets and aid in drug development
Cancer Biology
  • Implement cutting edge molecular and cellular techniques to determine target functions in cellโ€‘based solid tumor models
  • Develop data packages to prioritize targets and nominate candidates to the drug discovery stage
  • Individuals with expertise in oncogene/tumor suppressor pathways and/or drug resistance are especially encouraged to apply
Computational Biology, Data Science
  • Develop novel algorithms and apply deep learningโ€‘based approaches to network and proteomics datasets
  • Implement cloud infrastructure, pipelines, and UI/UX for data analytics
  • Conduct bioinformatic and statistical analyses of large, multimodal datasets
Compensation at Rezo

Actual starting salary will be determined based on multiple jobโ€‘related factors including a candidateโ€™s skills, education, and experience, the level at which they are hired, market demand, business needs, and internal parity. All fullโ€‘time roles are eligible for participation in our Annual Discretionary Bonus Plan (based on individual and company performance) and our Equity Incentive Plan, subject to the terms of those plans and associated policies. All fullโ€‘time positions are also eligible for the benefits detailed below.

Benefits at Rezo

Medical (HMO or PPO), dental, and vision insurance

Discretionary time off policy

Company holidays (including summer and winter shutdown)

401(k) retirement savings program

Commuter / Mass Transit Benefit Program

Healthcare Flexible Spending Account (FSA)

Dependent care Flexible Spending Account (FSA)

Parental leave

Competitive compensation

Flexible work schedule

EEOC

At Rezo we value a diverse, equitable, inclusive workplace and provide equal employment opportunity to all persons without regard to race, color, sex, gender identity, gender expression, religion, age, national origin, ancestry, citizenship, physical or mental disability, medical condition, family care status, marital status, domestic partner status, sexual orientation, genetic information, military or veteran status, or any other basis protected by federal, state or local laws. This statement covers all facets of employment and is especially important when it comes to growing our team.

If you are wondering if youโ€™ll belong at Rezo, or are worried that you donโ€™t meet 100% of the qualifications for this role, take a chance on us and yourself โ€” please apply!

SF Fair Chance Ordinance

Pursuant to the San Francisco Fair Chance Ordinance, Rezo considers qualified applicants with arrest and conviction records for employment.

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