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Sr Software Engineer Jobs in Rochester, MN (NOW HIRING)

Salas O'Brien

Senior Mechanical Engineer

Rochester, MN · On-site

$102K - $134K/yr

Senior Mechanical Engineer - Bloomington or Rochester, MN (Hybrid) SIGN-ON BONUS up to $10K The ... Perform Load/Energy calculations with software such as Trace 700, IES and similar programs

HGA

Sr Electrical Project Engineer

Rochester, MN · On-site

$101K - $134K/yr

Senior Electrical Project Engineer - Rochester, MN Award-winning Architecture, Engineering ... Familiarity with electrical analysis software (i.e. SKM, Easy Power, Helioscope) and knowledge of ...

HGA

Sr Electrical Project Engineer

Rochester, MN · Hybrid

$101K - $134K/yr

Senior Electrical Project Engineer - Rochester, MN Award-winning Architecture, Engineering ... Familiarity with electrical analysis software (i.e. SKM, Easy Power, Helioscope) and knowledge of ...

Mayo Clinic

Senior IT Analyst/Programmer

Rochester, MN · Hybrid

$102K - $143K/yr

Responsibilities The EHRT Reporting & Analytics team is looking for a Senior Analyst/Programmer to ... Maintains and supports multiple systems or complex software applications and their associated ...

Mayo Clinic

Senior IT Analyst/Programmer

Rochester, MN · Hybrid

$43.50 - $58.75/hr

The EHRT Reporting & Analytics team is looking for a Senior Analyst/Programmer to join our team to ... Maintains and supports multiple systems or complex software applications and their associated ...

Mayo Clinic

Senior IT Analyst/Programmer

Rochester, MN · Hybrid

$45.25 - $61.25/hr

The EHRT Reporting & Analytics team is looking for a Senior Analyst/Programmer to join our team to ... Maintains and supports multiple systems or complex software applications and their associated ...

GDIT

Full Stack Engineer, Mid

Rochester, MN · Hybrid

$140K - $189K/yr

Software Engineering Job Qualifications: Skills: Back-End Development, Data Ingestion, Flask (Web Framework), Python (Programming Language) Certifications: None Experience: 8 + years of related ...

GDIT

Network Engineer Senior

Rochester, MN · On-site

$93K - $108K/yr

Collaborate with network staff to ensure smooth and reliable operation of software and systems for ... Comprehensive knowledge of network engineering principles, methods, and techniques. * Knowledge of ...

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Showing results 1-20

All JobsSr Software Engineer JobsSr Software Engineer Jobs in Rochester, MN

Sr Software Engineer information

See Rochester, MN salary details

$73.7K

$139.9K

$187.4K

How much do sr software engineer jobs pay per year?

As of Jun 18, 2026, the average yearly pay for sr software engineer in Rochester, MN is $139,892.00, according to ZipRecruiter salary data. Most workers in this role earn between $119,600.00 and $157,700.00 per year, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive as a Sr Software Engineer, and why are they important?

To thrive as a Sr Software Engineer, you need advanced programming skills, a strong grasp of software design principles, and typically a degree in computer science or a related field. Expertise with development frameworks, version control systems like Git, and familiarity with cloud platforms or containerization tools is often required. Exceptional problem-solving abilities, clear communication, and leadership skills set top performers apart in collaborative environments. These competencies ensure the efficient delivery of high-quality software solutions and effective mentorship within development teams.

What are some common challenges Sr Software Engineers face when leading technical projects?

Sr Software Engineers often encounter challenges such as balancing hands-on coding with mentoring less experienced team members, managing shifting project requirements, and ensuring timely delivery while maintaining high code quality. They are frequently responsible for making critical architectural decisions and resolving complex technical issues that arise during the development process. Additionally, effective communication with cross-functional teams and stakeholders is key to aligning technical solutions with business goals.

What are Sr Software Engineers?

Sr Software Engineers are experienced professionals who design, develop, and maintain complex software systems. They often lead technical projects, mentor junior team members, and collaborate with stakeholders to ensure software meets business needs. In addition to coding, they are responsible for making architectural decisions, reviewing code, and ensuring best practices are followed. Sr Software Engineers typically have several years of industry experience and deep expertise in specific programming languages or technologies.
What are popular job titles related to Sr Software Engineer jobs in Rochester, MN? For Sr Software Engineer jobs in Rochester, MN, the most frequently searched job titles are:
What job categories do people searching Sr Software Engineer jobs in Rochester, MN look for? The top searched job categories for Sr Software Engineer jobs in Rochester, MN are:
What cities near Rochester, MN are hiring for Sr Software Engineer jobs? Cities near Rochester, MN with the most Sr Software Engineer job openings:
Sr Software Engineer jobs near you
Infographic showing various Sr Software Engineer job openings in Rochester, MN as of June 2026, with employment types broken down into 91% Full Time, and 9% Part Time. Highlights an 86% Physical, 5% Hybrid, and 9% Remote job distribution, with an average salary of $139,892 per year, or $67.3 per hour.
Senior Principal AI/ML Engineer - Research Sovereign AI

Senior Principal AI/ML Engineer - Research Sovereign AI

Mayo Clinic

Rochester, MN

$115K - $158K/yr

Full-time

Medical, Dental, Vision, Retirement

Posted 20 days ago

Mayo Clinic rating

7.8

Company rating: 7.8 out of 10

Based on 680 frontline employees who took The Breakroom Quiz

133rd of 873 rated healthcare providers

Job description

Position Summary

The Senior Principal AI/ML Engineer  for AI Representation & EMR Vectorization is the senior technical leader and lead scientist responsible for architecting Mayo Clinic's unified multimodal EMR representation layer. This role defines and builds the scientific substrate used by foundational models, clinical agents, and research applications. The individual serves as a hands-on expert and player-coach, guiding technical strategy while contributing directly to model development, graph construction, and representation science. Over time, this position will build and lead a specialized team. 

Key Responsibilities

Scientific & Technical Leadership

  • Design and implement Mayo's multimodal EMR representation AI architecture, including text, imaging, waveform, structured data, temporal sequences, and multi-visit trajectories.
  • Develop graph-based representations and knowledge graphs linking patients, events, attributes, clinical concepts, and embeddings.
  • Integrate graph reasoning, vector similarity search, and hybrid vector-graph pipelines for retrieval-augmented models and agentic reasoning.
  • Define standards for temporal modeling, drift-aware embeddings, and sequence alignment across encounters.

Hands-On Modeling & Engineering

  • Build large-scale embedding pipelines using transformer-based models, contrastive learning, graph neural networks, and hybrid architectures.
  • Implement efficient query layers using vector stores and graph databases.
  • Develop interpretable embedding diagnostics, attribution tools, and graph-based audits to enable safe clinical use.
  • Explore and implement methods for explaining similarity, graph traversals, temporal evolution, and patient-neighborhood reasoning.

Cross-functional Collaboration

  • Work with AI researchers on specialty-specific embeddings, representation refinement, and research prototypes.
  • Collaborate with clinicians to operationalize clinically meaningful features, phenotypes, and longitudinal concepts.
  • Provide scientific input to the Foundational Model Science Program to ensure alignment between representations and model architectures.

Team Leadership

  • Serve as founding technical lead of the Reasoning EMR Representation team.
  • Mentor junior scientists and engineers; build a future team specializing in representation learning and graph-based reasoning.
Why Mayo Clinic

Mayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our employees, investing in competitive compensation and comprehensive benefit plans - to take care of you and your family, now and in the future. And with continuing education and advancement opportunities at every turn, you can build a long, successful career with Mayo Clinic.

Benefits Highlights
  • Medical: Multiple plan options.
  • Dental: Delta Dental or reimbursement account for flexible coverage.
  • Vision: Affordable plan with national network.
  • Pre-Tax Savings: HSA and FSAs for eligible expenses.
  • Retirement: Competitive retirement package to secure your future.
Just as our reputation has spread beyond our Minnesota roots, so have our locations. Today, our employees are located at our three major campuses in Phoenix/Scottsdale, Arizona, Jacksonville, Florida, Rochester, Minnesota, and at Mayo Clinic Health System campuses throughout Midwestern communities, and at our international locations. Each Mayo Clinic location is a special place where our employees thrive in both their work and personal lives. Learn more about what each unique Mayo Clinic campus has to offer, and where your best fit is. 

Equal Opportunity

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, gender identity, sexual orientation, national origin, protected veteran status or disability status. Learn more about the "EOE is the Law".  Mayo Clinic participates in E-Verify and may provide the Social Security Administration and, if necessary, the Department of Homeland Security with information from each new employee's Form I-9 to confirm work authorization.

Required

  • Master's in Computer Science, Machine Learning, Biomedical Engineering, or related field. 9 years of relevant experience, or a bachelor's degree with 11 years of relevant experience. 
  •  Extensive (9+ years) experience applying AI and machine learning in production healthcare environments or similar highly regulated or technology focused industries, showcasing an acute understanding of healthcare technology.
  • Hands-on expertise with graph databases, and knowledge graph construction.
  • Strong experience with transformer-based models, contrastive learning, and temporal modeling.

  • Experience designing or deploying vector search systems and hybrid vector-graph reasoning pipelines.

Preferred

  • PhD or Master's in Computer Science, Machine Learning, Biomedical Engineering, or related field.
  • 10+ years experience building production ML systems, including multimodal architectures and representation learning.
  • Experience with EMR data, healthcare multimodality, or clinical data integration.
  • Experience building patient similarity models, temporal embedding systems, or phenotype discovery pipelines.
  • Strong background in explainability, causality, or interpretable ML.
  • Prior experience in a player-coach or team-lead role.

What Mayo Clinic employees say

Pay

Benefits

Hours and flexibility

Workplace

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About Mayo Clinic

Sourced by ZipRecruiter

Mayo Clinic is the largest integrated, not-for-profit medical group practice in the world. We're building the future, one where the best possible care is available to everyone — and more people can heal at home. Our relentless research turns into earlier diagnoses and new cures. That's how we inspire hope in those who need it most. At Mayo Clinic, experts work together to solve the most challenging unmet needs of patients. Our history of innovation dates back almost 150 years, when brothers Will and Charlie Mayo pioneered an integrated, team-based approach to medicine. Today, that trailblazing spirit drives innovations like Mayo Clinic Platform — which powers new technologies to change how care is delivered to all.

Industry

Hospitals

Company size

10,000+ Employees

Headquarters location

Rochester, MN, US

Year founded

1919

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