Spatial Transcriptomics Jobs in Spring House, PA

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Posted Job Title
Research Specialist A
Job Profile Title
Research Specialist A
Job Description Summary
The employee will work closely with the users of the Spatial Transcriptomics Core and Tissue Processing and Imaging Core at the School of Dental Medicine for 50% effort and also provide research support in the laboratory of Dr. Tizzano for the remaining 50% effort. For the two cores, the employee will be primarily responsible for performing the 10X Genomics Xenium In Situ workflow, and instrumentation training (slide scanner, cryostat) for core users. In Dr. Tizzano's lab, the employee will work on the role of taste receptors in solitary chemosensory cells and macrophages of the gingiva and other mucosae, using a variety of laboratory techniques. This position requires working with animals and working in the PDM vivarium. In each role, the employee will be responsible for general lab maintenance.
Job Description
Job Duties/Responsibilities
The employee will perform benchtop workflow for Xenium In Situ. This is a 3 day workflow including reagent preparation, slide de-paraffinization, tissue de-crosslinking, probe hybridization, ligation, amplification, cell segmentation staining, and Xenium analyzer preparation, loading, and clean-up. This involves meticulous adherence to a standardized protocol. Prior wet-lab experience is required, but specialized on-site training for this specific workflow will be provided.
The employee will be working closely with Dr. Tizzano and the Tizzano Lab personnel and the expected work includes, but it is not limited to: experiments of general cell biology and molecular biology, physiology, calcium imaging, cell culture, histology, immune assays, mouse surgery, RNA-seq, special transcriptomics, immunofluorescence microscopy. Responsibilities will include Tizzano lab and mouse colony maintenance, including but not limited to: chemical inventory, equipment's maintenance, receiving ordered supplies, keeping the lab organized, letting the PI know when supplies and chemicals are low for re-order, and mouse genotyping, breeding and weaning.
Other duties as assigned. Provide and maintain expertise in innovative solutions focused on the responsible stewardship of Penn Dental Medicine and its community experience
Qualifications

• Bachelor of Science and 0 to 1 year of experience or equivalent combination of education and experience is required.

Job Location - City, State
Philadelphia, Pennsylvania
Dr. Tizzano's laboratory at the University of Pennsylvania School of Dental Medicine in the Department of Basic and Translational Sciences is seeking a highly motivated Research Specialist A to join our multidisciplinary team. Moreover, the Spatial transcriptomics (PI: Dr. Larson), Tissue Processing and Imaging Cores (Dr. Tizzano) are seeking a highly motivated Research Specialist A to run experiments with our 10X Genomics Xenium In Situ setup and provide training on VS200 slide scanner and other instruments of the cores. No detailed experience in any of the above-mentioned areas is required. Candidates will be trained on site when necessary.
This is an excellent opportunity to learn a wide array of molecular biology, physiology, and genomics techniques and contribute to cutting-edge research on mucosal inflammation and infection.
Position is contingent upon continued grant and cores funding.
This position offers opportunities for independent research projects with opportunity for publication, as well as training in cutting-edge technologies.
Department / School
School of Dental Medicine
Pay Range
$45,278.00 - $47,500.00 Annual Rate
Salary offers are made based on the candidate's qualifications, experience, skills, and education as they directly relate to the requirements of the position, and in alignment with salary ranges based on external market data for the job's level. Internal organization and peer data at Penn are also considered.
Equal Opportunity Statement
The University of Pennsylvania is an equal opportunity employer. Candidates are considered for employment without regard to race, color, sex, sexual orientation, religion, creed, national origin (including shared ancestry or ethnic characteristics), citizenship status, age, disability, veteran status or any class protected under applicable federal, state or local law.
Special Requirements
Background checks may be required after a conditional job offer is made. Consideration of the background check will be tailored to the requirements of the job.
University Benefits

• Health, Life, and Flexible Spending Accounts: Penn offers comprehensive medical, prescription, behavioral health, dental, vision, and life insurance benefits to protect you and your family's health and welfare. You can also use flexible spending accounts to pay for eligible health care and dependent care expenses with pre-tax dollars.
• Tuition: Take advantage of Penn's exceptional tuition benefits. You, your spouse, and your dependent children can get tuition assistance here at Penn. Your dependent children are also eligible for tuition assistance at other institutions.
• Retirement: Penn offers generous retirement plans to help you save for your future. Penn's Basic, Matching, and Supplemental retirement plans allow you to save for retirement on a pre-tax or Roth basis. Choose from a wide variety of investment options through TIAA and Vanguard.
• Time Away from Work: Penn provides you with a substantial amount of time away from work during the course of the year. This allows you to relax, take vacations, attend to personal affairs, recover from illness or injury, spend time with family-whatever your personal needs may be.
• Long-Term Care Insurance: In partnership with Genworth Financial, Penn offers faculty and staff (and your eligible family members) long-term care insurance to help you cover some of the costs of long-term care services received at home, in the community or in a nursing facility. If you apply when you're newly hired, you won't have to provide proof of good health or be subject to underwriting requirements. Eligible family members must always provide proof of good health and are subject to underwriting.
• Wellness and Work-life Resources: Penn is committed to supporting our faculty and staff as they balance the competing demands of work and personal life. That's why we offer a wide variety of programs and resources to help you care for your health, your family, and your work-life balance.
• Professional and Personal Development: Penn provides an array of resources to help you advance yourself personally and professionally.
• University Resources: As a member of the Penn community, you have access to a wide range of University resources as well as cultural and recreational activities. Take advantage of the University's libraries and athletic facilities, or visit our arboretum and art galleries. There's always something going on at Penn, whether it's a new exhibit at the Penn Museum, the latest music or theater presentation at the Annenberg Center, or the Penn Relays at Franklin Field to name just a few examples. As a member of the Penn community, you're right in the middle of the excitement-and you and your family can enjoy many of these activities for free.
• Discounts and Special Services: From arts and entertainment to transportation and mortgages, you'll find great deals for University faculty and staff. Not only do Penn arts and cultural centers and museums offer free and discounted admission and memberships to faculty and staff. You can also enjoy substantial savings on other goods and services such as new cars from Ford and General Motors, cellular phone service plans, movie tickets, and admission to theme parks.
• Flexible Work Hours: Flexible work options offer creative approaches for completing work while promoting balance between work and personal commitments. These approaches involve use of non-traditional work hours, locations, and/or job structures.
• Penn Home Ownership Services: Penn offers a forgivable loan for eligible employees interested in buying a home or currently residing in West Philadelphia, which can be used for closing costs or home improvements.
• Adoption Assistance: Penn will reimburse eligible employees on qualified expenses in connection with the legal adoption of an eligible child, such as travel or court fees, for up to two adoptions in your household.

To learn more, please visit: https://www.hr.upenn.edu/PennHR/benefits-pay