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Spatial Biology Jobs in Minnesota (NOW HIRING)

The focus of the core initially will be on spatial biology and multimodal omics integration to aid P30 members in discovery science. In this role, you will work for the AI Core along with a medical ...

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Bioinformatics Scientist

Minneapolis, MN · On-site

$110K - $120K/yr

A Ph. D or equivalent experience in biology, chemistry or bioinformatics with strong skills in the analysis of - Omics datasets (bulk/single-cell/spatial transcriptomics, WES, epigenomics ...

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Spatial Biology information

What is spatial biology?

Spatial biology is a field of science that studies the spatial organization and interactions of cells and molecules within tissues. By analyzing where specific cells and proteins are located in relation to each other, researchers can gain insights into how tissues function in health and disease. Techniques such as spatial transcriptomics and multiplex imaging are commonly used in spatial biology to map and visualize these complex relationships. This information is valuable for understanding diseases like cancer, where the tissue environment plays a critical role.

What are some common challenges faced by professionals working in spatial biology, and how can they be addressed?

Professionals in spatial biology often encounter challenges related to managing and interpreting large, complex datasets generated from advanced imaging and sequencing technologies. Integrating multidisciplinary knowledge—such as molecular biology, bioinformatics, and imaging analysis—is also essential, requiring ongoing learning and collaboration across fields. These challenges can be addressed by staying current with technological advancements, utilizing robust data analysis tools, and actively collaborating with bioinformaticians, pathologists, and other specialists to ensure accurate data interpretation and project success.

What are the key skills and qualifications needed to thrive as a spatial biologist, and why are they important?

To thrive as a Spatial Biologist, you need a strong background in molecular biology, histology, and data analysis, typically supported by an advanced degree in biology or related fields. Familiarity with spatial transcriptomics platforms, imaging technologies, and bioinformatics tools such as R or Python is essential. Strong problem-solving abilities, attention to detail, and effective teamwork are vital soft skills for excelling in this role. These skills ensure accurate experimental design, data interpretation, and collaborative progress in cutting-edge biological research.

What is the difference between Spatial Biology vs Cell Biologist?

AspectSpatial BiologyCell Biologist
Required CredentialsMaster's or PhD in Biology, Biotechnology, or related fieldsMaster's or PhD in Cell Biology, Molecular Biology, or related fields
Work EnvironmentResearch labs, biotech companies, academic institutions focusing on tissue and cellular spatial analysisLaboratories, research institutions studying cell structure, function, and mechanisms
Industry UsageUsed in genomics, proteomics, and tissue analysis to understand spatial contextApplied in basic and applied research on cell function and disease mechanisms

Spatial Biology and Cell Biologist roles share foundational biology knowledge and advanced laboratory skills. However, Spatial Biology focuses on analyzing the spatial organization of molecules within tissues, often requiring specialized imaging techniques, while Cell Biologists study cell structure and function more broadly. Both roles are vital in research and biotech industries, but Spatial Biology is more specialized in spatial analysis techniques.

What cities in Minnesota are hiring for Spatial Biology jobs? Cities in Minnesota with the most Spatial Biology job openings:
Infographic showing various Spatial Biology job openings in Minnesota as of August 2026, with employment types broken down into 70% Full Time, 26% Part Time, 1% Temporary, and 3% Contract. Highlights an 79% Physical, 3% Hybrid, and 18% Remote job distribution.

Senior Data Science Analyst - CSiG

Mayo Clinic

Rochester, MN

$87K - $110K/yr

Full-time

Medical, Dental, Vision, Retirement

Posted yesterday

New


Mayo Clinic rating

7.8

Company rating: 7.8 out of 10

Based on 697 frontline employees who took The Breakroom Quiz

130th of 887 rated healthcare providers


Job description

Why Mayo Clinic

Mayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our employees, investing in competitive compensation and comprehensive benefit plans - to take care of you and your family, now and in the future. And with continuing education and advancement opportunities at every turn, you can build a long, successful career with Mayo Clinic.

Benefits Highlights
  • Medical: Multiple plan options.
  • Dental: Delta Dental or reimbursement account for flexible coverage.
  • Vision: Affordable plan with national network.
  • Pre-Tax Savings: HSA and FSAs for eligible expenses.
  • Retirement: Competitive retirement package to secure your future.

Responsibilities

The Artificial Intelligence (AI) Core is a key component of the NIH funded P30 Digestive Diseases Research Core Center grant, which is entitled the Mayo Clinic Center for Cell Signaling in Gastroenterology. We are seeking a Senior Data Science Analyst to join our AI core to help develop, organize, and employ agentic AI based solutions powered by stacked frontier models. The focus of the core initially will be on spatial biology and multimodal omics integration to aid P30 members in discovery science. In this role, you will work for the AI Core along with a medical and scientific director (co-directors) and actively support members in the use of agentic AI models while simultaneously driving the rigorous experimental frameworks required to validate them. By bridging the gap between model training and statistical science, you will ensure our systems are not just performative, but biologically generalizable and ready to transform the future of digestive disease research.

Data Scientists at Mayo Clinic perform detailed analysis of large bodies of scientific data in order to discover new patterns and insights having an impact ultimately upon patient health. The preferred candidate has advanced expertise in AI, machine learning, deep learning, statistical data processing, regression techniques, neural networks, decision trees, clustering, pattern recognition, probability theory, and data science methods and the mathematical theories underlying these tools used to analyze data. The individual should have advanced knowledge of computational biology data types, topics, and scientific challenges and approaches.

You may work with knowledge architects, informaticians, and clinicians at Mayo to develop and deploy applications to bring AI and analytic solutions to nontechnical users, often at the point of omics data including transcriptomics, genetics, proteomics, and spatial biology. The core applies and modifies existing scripts or software applications to support data management, data extraction, data analysis, and AI, as required, by leveraging advanced statistical modeling, operations research, machine learning, or data mining techniques. You will provide consultative services at a scientific level to support scientific projects. You will be housed within a digital biology-focused team focused on advanced AI technology for Mayo Clinic Digital Pathology.

Note: Visa sponsorship is not available for this position. Must be a U.S. citizen, permanent resident, refugee, or asylee. Mayo Clinic does not support the OPT STEM program.


Qualifications

A bachelor's degree in a relevant field such as engineering, mathematics, computer science, health science and at least 12 graduate level semester hours in domain-relevant sciences or seven years or more of data science and AI experience is required. The ideal candidate will possess a PhD in a relevant field such as engineering, mathematics, computer science, bioinformatics/biostatistics, biological sciences, or other analytical/quantitative field. Requisite technical expertise in AI, data science, and the use of scientific computing and data management packages in strongly preferred. In addition, the role requires experience with data modeling and data exploration tools, along with advanced computer applications skills, strong analytical skills, and the ability to identify and recommend effective technical solutions.
The incumbent must have proven leadership, project management, and time management skills, including the ability to prioritize, organize, delegate, and manage a varied workload of projects with multiple priorities while staying current on scientific trends. The role requires advanced written and oral communication skills, including the ability to provide AI-related text for publications and grants, to deliver clear presentations, and to impart effective education to learners with varying levels of expertise. The preferred candidate will have strong interpersonal and consulting skills, including a demonstrated ability to provide consultative services to scientists and co-workers from any Mayo entity requesting assistance, along with a commitment to customer service. 


Exemption Status
Exempt
Compensation Detail
$125,444.80 - $ 188,260.80 / year; Education, experience and tenure may be considered along with internal equity when job offers are extended.
Benefits Eligible
Yes
Schedule
Full Time
Hours/Pay Period
80
Schedule Details
Monday - Friday; Regular business hours; On-site expectations are determined by the supervisor and will be discussed during the interview.
Weekend Schedule
N/A
International Assignment
No
Site Description
Just as our reputation has spread beyond our Minnesota roots, so have our locations. Today, our employees are located at our three major campuses in Phoenix/Scottsdale, Arizona, Jacksonville, Florida, Rochester, Minnesota, and at Mayo Clinic Health System campuses throughout Midwestern communities, and at our international locations. Each Mayo Clinic location is a special place where our employees thrive in both their work and personal lives. Learn more about what each unique Mayo Clinic campus has to offer, and where your best fit is. 

Equal Opportunity

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, gender identity, sexual orientation, national origin, protected veteran status or disability status. Learn more about the 'EOE is the Law'.  Mayo Clinic participates in E-Verify and may provide the Social Security Administration and, if necessary, the Department of Homeland Security with information from each new employee's Form I-9 to confirm work authorization.

Recruiter
Stephanie BairdQualifications:

A bachelor's degree in a relevant field such as engineering, mathematics, computer science, health science and at least 12 graduate level semester hours in domain-relevant sciences or seven years or more of data science and AI experience is required. The ideal candidate will possess a PhD in a relevant field such as engineering, mathematics, computer science, bioinformatics/biostatistics, biological sciences, or other analytical/quantitative field. Requisite technical expertise in AI, data science, and the use of scientific computing and data management packages in strongly preferred. In addition, the role requires experience with data modeling and data exploration tools, along with advanced computer applications skills, strong analytical skills, and the ability to identify and recommend effective technical solutions.
The incumbent must have proven leadership, project management, and time management skills, including the ability to prioritize, organize, delegate, and manage a varied workload of projects with multiple priorities while staying current on scientific trends. The role requires advanced written and oral communication skills, including the ability to provide AI-related text for publications and grants, to deliver clear presentations, and to impart effective education to learners with varying levels of expertise. The preferred candidate will have strong interpersonal and consulting skills, including a demonstrated ability to provide consultative services to scientists and co-workers from any Mayo entity requesting assistance, along with a commitment to customer service. 


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About Mayo Clinic

Sourced by ZipRecruiter

Mayo Clinic is the largest integrated, not-for-profit medical group practice in the world. We're building the future, one where the best possible care is available to everyone — and more people can heal at home. Our relentless research turns into earlier diagnoses and new cures. That's how we inspire hope in those who need it most. At Mayo Clinic, experts work together to solve the most challenging unmet needs of patients. Our history of innovation dates back almost 150 years, when brothers Will and Charlie Mayo pioneered an integrated, team-based approach to medicine. Today, that trailblazing spirit drives innovations like Mayo Clinic Platform — which powers new technologies to change how care is delivered to all.

Industry

Hospitals

Company size

10,000+ Employees

Headquarters location

Rochester, MN, US

Year founded

1919