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Silico Protein Design Jobs (NOW HIRING)

Achira

CADD / Application Scientist

New York, NY · On-site

... first protein-ligand applications in potency and lead optimization toward a broader vision: bringing more of the wet lab in silico, from selectivity and ADMET to eventual de novo molecular design.

Gilead

Senior Scientist, Molecular Biology

Foster City, CA · On-site

$106K - $145K/yr

... sequence design in silico to high-quality, expression-ready constructs for recombinant protein expression at all scales. The ideal candidate will possess extensive molecular biology expertise ...

Gilead

Senior Scientist, Molecular Biology

Foster City, CA

$106K - $145K/yr

... sequence design in silico to high-quality, expression-ready constructs for recombinant protein expression at all scales. The ideal candidate will possess extensive molecular biology expertise ...

UAB

SCIENTIST III

Tampa, FL

... silico computational studies, and lead lab-in-the-loop collaborations with UAB, regional, and ... Active research areas include protein and antibody design, novel AI approaches to molecular ...

UAB NOVA RENT

SCIENTIST III

Birmingham, AL · On-site

... silico computational studies, and lead lab-in-the-loop collaborations with UAB, regional, and ... Active research areas include protein and antibody design, novel AI approaches to molecular ...

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Silico Protein Design information

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$42K

$114.5K

$201.5K

How much do silico protein design jobs pay per year?

As of Jun 15, 2026, the average yearly pay for silico protein design in the United States is $114,491.00, according to ZipRecruiter salary data. Most workers in this role earn between $83,500.00 and $144,000.00 per year, depending on experience, location, and employer.

What are some common challenges faced by professionals in Silico Protein Design and how can they be addressed?

Professionals in Silico Protein Design often encounter challenges such as handling the complexity of protein structures, ensuring computational predictions translate effectively to laboratory results, and keeping up with the rapid evolution of bioinformatics tools. To address these, it's important to work closely with experimental teams, stay updated on the latest software and databases, and continuously refine computational models based on feedback from experimental validation. Collaboration and ongoing learning are key to overcoming these hurdles and advancing in this innovative field.

What is silico protein design?

Silico protein design refers to the use of computer algorithms and software to model, predict, and create new protein structures with desired functions. This process allows scientists to simulate how amino acid sequences will fold and behave, enabling the design of proteins for specific applications such as therapeutics, enzymes, or materials. By leveraging computational tools, researchers can save time and resources compared to traditional experimental methods, making the protein engineering process more efficient and innovative.

What is the difference between Silico Protein Design vs Protein Biochemist?

AspectSilico Protein DesignProtein Biochemist
Required CredentialsDegree in Bioinformatics, Computational Biology, or related fieldDegree in Biochemistry, Molecular Biology, or related field
Work EnvironmentPrimarily computational, using software and modeling toolsLaboratory-based, involving wet lab experiments
Industry UsageResearch and development in biotech, pharmaceuticals, academiaResearch, diagnostics, and product development in biotech and pharma

Silico Protein Design focuses on using computational methods to predict and engineer protein structures, while Protein Biochemists perform laboratory experiments to study protein functions. Both roles are essential in biotech and pharma industries but differ mainly in their approach—digital modeling versus wet lab work.

What are the key skills and qualifications needed to thrive as an In Silico Protein Designer, and why are they important?

To thrive as an In Silico Protein Designer, you need a solid background in molecular biology, computational modeling, and protein biochemistry, typically supported by a relevant advanced degree. Familiarity with bioinformatics tools, molecular modeling software (like Rosetta or PyMOL), and programming languages such as Python is crucial. Strong analytical thinking, attention to detail, and effective collaboration skills help you interpret complex data and work within multidisciplinary teams. These competencies enable the accurate design and optimization of proteins for research and therapeutic applications, ensuring innovation and scientific rigor.
Infographic showing various Silico Protein Design job openings in the United States as of June 2026, with employment types broken down into 100% Full Time. Highlights an 86% Physical, 4% Hybrid, and 10% Remote job distribution, with an average salary of $114,491 per year, or $55 per hour.

Automation Technical Product Manager, Protein Development

Jj

Spring House, PA • On-site

$159K - $184K/yr

Full-time

Posted 11 days ago

Job description

At Johnson & Johnson,we believe health is everything. Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented, treated, and cured,where treatments are smarter and less invasive, andsolutions are personal.Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity.Learn more at jnj.com.

As guided by Our Credo, Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson, we respect the diversity and dignity of our employees and recognize their merit.

Job Function:

Technology Product & Platform Management

Job Sub Function:

Technical Product Management

Job Category:

Scientific/Technology

All Job Posting Locations:

Malvern, Pennsylvania, United States of America, Spring House, Pennsylvania, United States of America

Job Description:

Johnson & Johnson Innovative Medicine, R&D is recruiting for the role of Automation Technical Product Manager, Protein Development, located in Spring House, PA, USA or Malvern, PA, USA.

The mission of the Therapeutics Development Product Group is to implement innovative technology to transform the development and delivery of life changing medicines for the J&J IM, R&D portfolio; focusing on Automation and Computation as the Business Technology North Star.

In this role, the candidate will re-define our global protein therapeutic development labs into the data-centric highly automated lab of the future. The role will have a strong focus on end to end data flow via integration of disparate data systems and implementation of digital strategies to enable Digital Twin technology, ensuring technical solutions to drive the best science and FAIR data.

Key Responsibilities:

  • Own end-user facing tools for services including but not limited to: computational fluid dynamics modeling, in silico drug development tools, cell engineering analyses, and digital automation programs; modernize the AWS landscape to ensure security, containerization, and cost-efficiency.
  • Technical Owner of SaaS and OPx/VPx based applications for lab operating and analysis technologies; coordinate server install and upgrades for bioreactor systems such as Ignition and BioBrain.
  • Deliver innovative digital solutions for process automation, standardization and integration with digital platform architecture; drive lean documentation practices in accordance with SDLC.
  • Work with functional teams to build digital roadmaps for E2E data flows from collection to consumption, including action plans and resourcing/funding proposals for capital and operating expenses.
  • Collaborate across business areas with partners, vendors, technical staff and project teams to drive value and deploy innovative solutions.
  • Continuously review the business needs, refine priorities, and champion organizational change.
  • Establish Outcomes & Key Results and metrics to evaluate performance and user happiness.
  • Understand and apply Johnson & Johnson's Credo and Leadership Imperatives in day-to-day interactions with team.

Qualifications

Education:

  • A Bachelor's degree is required preferably in Biotechnology, Computer Science, Systems/Automation Engineering or a related subject area.
  • A Master's degree is preferred.

Experience and Skills:

Required:

  • Minimum 5 years' experience enabling technical scientific solutions within the pharmaceutical or like industry.
  • Proficiency in AWS S3, EC2, Lambda, cost management and modernization.
  • Strong foundational IT skills including architecture principles, data engineering, cloud computing, AI/ML and database design.
  • Experienced in SDLC for GxP data systems.
  • Understanding data flows between end-users, instruments and execution systems.
  • Knowledge of network connection setup to support R&D labs (firewalls, server connections, cyber security).
  • Experience with programming language for data integration and extraction (Python, Java, R..).
  • Commercial software technical management and vendor relationship.
  • Agile methodology approach and project management tools (e.g., JIRA, Confluence, Asset Management, BitBucket/GitHub).
  • Ability to interpret complex requirements and derive actionable insights.
  • Superb communication & ability to influence, negotiate, and build partnerships, teams, and trust across functions.

Preferred:

  • Experience in a scientific, digital product, or lab operations environment, specifically biologic drug development or R&D.
  • Commercial software deployments or upgrades at a global scale.
  • Experienced with ISA-88/95 and ability to establish standards across global sites.
  • Working understanding of OPC Unified Architecture and Event/Asset Framework.
  • Experience in leading a team of external resources.
  • Understanding of data lakes, eLab Notebooks and historians.
  • Data connections to support PAT (spectral data etc), experience with SynTQ or Process Pulse.

Other:

  • Up to 10% Travel

#JNJTECH

#LI-Hybrid

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.

Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants' needs. If you are an individual with a disability and would like to request an accommodation, please contact us via https://www.jnj.com/contact-us/careers or contact AskGS to be directed to your accommodation resource.

Required Skills:

Preferred Skills:

Analytical Reasoning, Coaching, Cost Management, Critical Thinking, Give Feedback, Human-Computer Interaction (HCI), Organizing, Performance Measurement, Product Development, Product Improvements, Product Strategies, Project Management Methodology (PMM), Research and Development, Software Development Management, Strategic Supply Chain Management, Technical Credibility, Technical Writing

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