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Senior Statistical Programmer Jobs in Lowell, MA

Cytel

Senior Statistical Programmer FSP

Cambridge, MA · On-site +1

As a Senior Statistical Programmer you will be dedicated to one of our global pharmaceutical clients; a company that is driving the next generation of patient treatment, where individuals are ...

Vrtx

Principal Statistical Programmer

Boston, MA · Remote

$149K - $223K/yr

The Principal Statistical Programmer works with management to delegate tasks appropriately, track ... Senior Management levels * Creates all files, documents, and analyses necessary to support an ...

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Senior Statistical Programmer information

See Lowell, MA salary details

$81.8K

$127.2K

$166.1K

How much do senior statistical programmer jobs pay per year?

As of Sep 3, 2026, the average yearly pay for senior statistical programmer in Lowell, MA is $127,237.00, according to ZipRecruiter salary data. Most workers in this role earn between $106,100.00 and $146,800.00 per year, depending on experience, location, and employer.

What is a senior statistical programmer?

A Senior Statistical Programmer is responsible for developing, testing, and validating statistical programs used for clinical trial data analysis. They work primarily with statistical software like SAS to generate tables, listings, and figures (TLFs) for regulatory submissions and research studies. This role requires strong programming skills, knowledge of statistical methodologies, and an understanding of clinical trial processes. Senior Statistical Programmers also collaborate with statisticians, data managers, and regulatory teams to ensure data integrity and compliance with industry standards.

What are the typical responsibilities and team dynamics for a senior statistical programmer?

As a Senior Statistical Programmer, you will typically be responsible for designing, developing, and validating statistical programs for clinical trial data analysis and reporting. You’ll work closely with biostatisticians, data managers, and clinical project teams to ensure data quality and regulatory compliance, often contributing to the creation of submission datasets and study reports. The role usually involves both independent work and active collaboration, with seasoned programmers frequently mentoring junior staff and participating in process improvement initiatives. This team-oriented structure offers exposure to a variety of projects and stakeholders, making it a dynamic environment ideal for those who enjoy both analytical tasks and cross-functional teamwork.

What are the key skills and qualifications needed to thrive as a senior statistical programmer, and why are they important?

To thrive as a Senior Statistical Programmer, a strong background in statistical analysis, programming (often in SAS and R), and a relevant degree such as in statistics, mathematics, or computer science is essential. Experience with regulatory submission standards (like CDISC SDTM/ADaM), clinical trial software, and certifications such as SAS Certified Advanced Programmer are highly valued. Outstanding attention to detail, problem-solving abilities, and effective communication skills help individuals excel in this collaborative and deadline-driven role. These skills are crucial for ensuring accurate data analysis, regulatory compliance, and successful teamwork in high-stakes research environments.

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Senior Statistical Programmer jobs near you
Infographic showing various Senior Statistical Programmer job openings in Lowell, MA as of August 2026, with employment types broken down into 1% Internship, 79% Full Time, 16% Part Time, and 4% Contract. Highlights an 84% Physical, 3% Hybrid, and 13% Remote job distribution, with an average salary of $127,237 per year, or $61.2 per hour.

Senior Statistical Programmer

Rhythm Pharmaceuticals

Boston, MA • On-site

Full-time

Posted yesterday

New

Job description

Company Overview
Rhythm is a global, commercial-stage biopharmaceutical company committed to transforming the lives of patients living with rare neuroendocrine diseases. We develop medicines for previously untreatable or undertreated diseases. We recognize the courage it takes for patients and their caregivers to begin their journey of advocacy to find the answers they need. Their courage inspires us to challenge convention, ask bold questions and seek answers for them. Every day, we strive for excellence through our willingness to adapt, learn, and our tenacity to overcome barriers, together.
Opportunity Overview
Rhythm is seeking a Senior Statistical Programmer to join our Biostatistics and Statistical Programming team. This role will provide statistical programming hands-on support across clinical studies, regulatory submissions, and cross-functional development activities. The successful candidate will be responsible for delivering high-quality, compliant analysis datasets, tables, listings, and figures; contributing to study-level and integrated submission deliverables; and partnering closely with Biostatistics, Data Management, Clinical Development, Medical Writing, Regulatory, and external vendors. Depending on level, the role may also include broader responsibility for study oversight, process improvement, standards development, vendor oversight, and mentoring programmers. The level will be determined based on the candidate’s experience, technical depth, and leadership capabilities.
Responsibilities and Duties
  • Lead or support statistical programming activities for assigned clinical studies, including development, validation, and quality control of analysis datasets, tables, listings, and figures for study reports, regulatory submissions, and internal decision-making.
  • Serve as a study lead programmer or programming representative, partnering closely with Biostatistics, Data Management, Clinical Development, Medical Writing, Regulatory, and external vendors to deliver high-quality results on time.
  • Develop, review, and maintain ADaM specifications, TLF shells, programming documentation, reusable macros, and study-level programming standards in alignment with company procedures and regulatory expectations.
  • Provide input into protocols, statistical analysis plans, CRF design and annotation, edit checks, SDTM specifications, integrated data review, and submission strategy to ensure traceability, consistency, and efficient downstream analysis.
  • Support regulatory submission readiness, including preparation and review of define.xml, reviewer guides, submission-ready datasets, and related documentation in compliance with CDISC and global regulatory requirements.
  • Identify programming risks, drive issue resolution, and recommend process improvements that enhance quality, scalability, efficiency, and inspection readiness across studies and programs.
  • Depending on level, mentor junior programmers, provide technical guidance, contribute to resource planning, oversee vendor deliverables, and help shape departmental standards, tools, and best practices.

Qualifications and Skills
  • MS or equivalent degree in Statistics, Biostatistics, Mathematics, Computer Science, or a related discipline; advanced degree preferred.
  • 3+ years relevant statistical programming experience in biotech, pharma, or CRO settings; vendor oversight experience preferred but not required.
  • Strong hands-on expertise in SAS programming, including Base SAS, SAS/STAT, SAS/GRAPH, SAS/SQL, SAS/ODS, and macro development; experience with R or other modern programming tools is a plus.
  • Deep knowledge of CDISC standards, including SDTM, ADaM, define.xml, reviewer guides, and electronic submission requirements in eCTD format.
  • Experience supporting study-level and integrated analyses, including ISS/ISE or other cross-study deliverables, with strong understanding of clinical trial reporting and regulatory submission processes.
  • Able to work independently, manage priorities, collaborate cross-functionally, and deliver high-quality work in a fast-paced environment.
  • For manager-level candidates, experience mentoring programmers, overseeing external vendors, and contributing to resource planning or process improvement is a plus.

This role is based out of our corporate office in Boston, Massachusetts. Rhythm operates in a hybrid-work model. Candidates applying must be willing and able to be in the Boston office in coordination with their department and business needs. This role may involve some travel.
The expected salary range for this position is $90,000 - $135,000. Actual pay will be determined based on experience, level, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and company performance. This role may be eligible for benefits and other compensation such as restricted stock units.
More about Rhythm
We are a dynamic and growing global team spanning more than a dozen countries. At Rhythm we are dedicated to transforming the lives of patients living with rare neuroendocrine diseases by rapidly advancing care and precision medicines that address the root cause.  Our team is passionate about expanding access to reach more patients and developing novel therapies for other rare neuroendocrine diseases, including congenital hyperinsulinism.
 
At Rhythm our core values are:
  • We are committed to advancing scientific understanding to improve patients’ lives
  • We are inspired to tackle tough challenges and have the courage to ask bold questions
  • We are eager to learn and adapt
  • We believe collaboration and ownership are foundational for our success
  • We value the unique contribution each individual brings to furthering our mission

Inherent in our core values is the commitment to act ethically and with integrity in all we do.
Rhythm is an equal employment opportunity employer and does not discriminate against any applicant because of race, creed, color, age, national origin, ancestry, religion, gender, sexual orientation, disability, genetic information, veteran status, military status, application for military service, or any other class protected by state or federal law. 
Headquartered in Boston, Rhythm is proud to have been named one of the Top Places to Work in Massachusetts.

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