1

Senior Scientist Downstream Process Development Jobs in Tennessee

Sr. Research Scientist

Johnson City, TN

$94K - $120K/yr

The Senior Research Scientist is responsible for leading the development of innovative skincare and ... Partner closely with Process Development and Manufacturing teams to support formulation scale-up ...

Sr. Research Scientist

Johnson City, TN · On-site

$94K - $120K/yr

The Senior Research Scientist is responsible for leading the development of innovative skincare and ... Partner closely with Process Development and Manufacturing teams to support formulation scale-up ...

Process Engineer

Greeneville, TN · On-site

$70K - $90K/yr

Injection molding process development and optimization. * Scientific molding and process validation methodologies. * Plastic resin behavior, material drying, and material handling systems.

Senior Process Engineer

Knoxville, TN

$99K - $128K/yr

Our client is seeking - Senior Process Engineer, responsible for establishing, maintaining and ... This role serves as the primary owner for transitioning new processes from R&D into full-scale ...

New

This role will focus on extrusion process development, tooling design, equipment performance ... Science, or Materials Engineering. * Experience setting up extrusion equipment, running product ...

Showing results 41-60

Senior Scientist Downstream Process Development information

What does a senior scientist in downstream process development do?

A Senior Scientist in Downstream Process Development focuses on developing, optimizing, and scaling up processes to purify biological products such as proteins or antibodies after cell culture (the 'downstream' part of biomanufacturing). They design experiments, analyze data, and work with cross-functional teams to ensure product quality and regulatory compliance. Their role is critical in moving biopharmaceutical products from research to commercial production by ensuring efficient and robust purification processes.

What are the key skills and qualifications needed to thrive as a senior scientist in downstream process development?

To thrive as a Senior Scientist in Downstream Process Development, you need advanced knowledge in bioprocess engineering, protein purification, and process scale-up, typically supported by a Ph.D. or Master’s degree in a relevant field. Expertise with chromatography systems (such as AKTA), analytical instrumentation, and familiarity with regulatory requirements like GMP are essential. Strong problem-solving abilities, leadership, and effective communication skills distinguish top performers in this role. These competencies are crucial for developing robust, scalable processes that meet quality standards and drive successful product development.

What are some common challenges faced by senior scientists in downstream process development, and how can they be addressed?

Senior Scientists in Downstream Process Development often encounter challenges such as optimizing purification processes for novel biologics, scaling up from lab to production scale, and ensuring product consistency and regulatory compliance. Addressing these challenges typically involves close collaboration with cross-functional teams, continuous process optimization, and staying current with industry advancements in chromatography and filtration technologies. Proactive problem-solving, effective communication, and leveraging data analytics are also key strategies for overcoming obstacles in this role.

What are popular job titles related to Senior Scientist Downstream Process Development jobs in Tennessee?

For Senior Scientist Downstream Process Development jobs in Tennessee, the most frequently searched job titles are:

What job categories do people searching Senior Scientist Downstream Process Development jobs in Tennessee look for?

The top searched job categories for Senior Scientist Downstream Process Development jobs in Tennessee are:

What cities in Tennessee are hiring for Senior Scientist Downstream Process Development jobs?

Cities in Tennessee with the most Senior Scientist Downstream Process Development job openings:

Infographic showing various Senior Scientist Downstream Process Development job openings in Tennessee as of August 2026, with employment types broken down into 83% Full Time, and 17% Contract. Highlights an 100% In-person job distribution.

Senior Research Scientist - Nuclear Materials and Radiation Effects

Fusion Energy Base

Oak Ridge, TN • On-site

$140 - $210/hr

Other

Medical, Dental, Vision, Life, Retirement, PTO

Posted 3 days ago

New


Job description

Overview

Oak Ridge National Laboratory (ORNL) invites applications for a senior scientific leadership position to advance the science and technology of materials for extreme environments, with an emphasis on the convergence of fusion and fission structural materials, reactor core materials innovation, and the expansion of nuclear materials research capabilities. This position resides in the Radiation Effects and Microstructural Analysis Group (REMAG) within the Materials in Extreme Environments Section of the Materials Science and Technology Division in ORNL’s Physical Sciences Directorate. Working in partnership with the U.S. Department of Energy’s (DOE) Office of Fusion Energy Sciences (FES), Office of Nuclear Energy (NE), and Office of Basic Energy Sciences (BES), as well as industry, universities, and other external stakeholders, the selected candidate will leverage internationally recognized expertise in nuclear materials science to develop and lead innovative research programs that advance next-generation nuclear energy technologies. The candidate will provide scientific leadership in the strategic planning and execution of initiatives that support the expansion, modernization, and integration of capabilities in nuclear materials development, irradiation experimentation, modeling and simulation, and post-irradiation examination (PIE). The candidate will also play a central role in bridging fundamental and applied research to enable transformative advances in fission and fusion energy systems. Through research on radiation effects, microstructural evolution, degradation mechanisms, and materials performance in extreme environments, the candidate will advance the scientific foundation needed to develop resilient nuclear materials and technologies. This position represents a unique opportunity to strengthen ORNL’s leadership in nuclear materials science and technology at both the national and international levels while supporting DOE’s mission to advance clean energy, energy security, and scientific discovery.

Major Duties/Responsibilities
  • Establish leadership in scientific research and capability expansion for advanced nuclear materials and radiation effects in materials science.
  • Directly contribute to the laboratory’s vision of advancing breakthrough fusion and fission energy systems that are pivotal to the nation’s energy future.
  • Develop new projects and programs by leveraging capabilities in experimental design, complex data analysis, technology and process development, and effective communication of findings through reports and presentations.
  • Lead advanced research by applying scientific principles to engineer innovative solutions, mentor junior staff, ensure compliance with standards, manage budgets, and collaborate with internal teams and external partners.
  • Maintain a strong commitment to the implementation and perpetuation of organizational values and ethics.
  • Advance ORNL’s mission by aligning behaviors, priorities, and interactions with our core values of Impact, Integrity, Teamwork, Safety, and Service.
  • Promote equal opportunity by fostering a respectful workplace—in how we treat one another, collaborate, and define success.
Basic Qualifications
  • Ph.D. in Materials Science and Engineering, Nuclear Engineering (with a focus on materials), or a closely related field.
  • A minimum of 10 years of post-Ph.D. research experience in fission, fusion, or accelerator materials, or other materials for extreme environments.
  • A strong record of publications and citations.
  • Demonstrated leadership in scientific research programs, research organizations, or the professional scientific community.
Preferred Qualifications
  • Demonstrated leadership experience in scientific research, such as serving as a program or project manager, with a record of mentoring early-career researchers, postdoctoral associates, or graduate students.
  • Extensive experience in the post-irradiation examination of radioactive structural or fuel materials, or in the analysis of materials behavior in nuclear reactor environments.
  • Excellent written and oral communication skills, as evidenced by a strong record of publications in high-impact journals and presentations.
  • Motivated self-starter with the ability to work independently and contribute creatively within collaborative, cross-disciplinary teams across the laboratory.
  • Proven ability to perform effectively in a fast-paced research environment, set priorities, manage multiple tasks within deadlines, and adapt to evolving program needs.
  • Ability to obtain and maintain the required security (Q or L) clearance immediately or within a reasonable timeframe.
Special Requirements
  • Security, Credentialing, and Eligibility Requirements: For employment at ORNL, a Real ID compliant form of identification will be required. ORNL is subject to Department of Energy (DOE) access restrictions. All employees must also be able to obtain and maintain a federal Personal Identity Verification (PIV) card as mandated by HSPD-12 and DOE Order 473.1A, which requires a favorable post-employment background investigation.
  • To obtain this credential, new employees must successfully complete and pass a Federal Tier 1 background check investigation, including a declaration of illegal drug activities within the last year. This includes marijuana and cannabis derivatives, which are still considered illegal under federal law, regardless of state laws.
  • For foreign national candidates: If you have not resided in the U.S. for three consecutive years, you are not eligible for the PIV credential and will need a favorable Local Site Specific Only (LSSO) risk determination. After meeting the residency requirement, you will be required to obtain a PIV credential.
Letters of Recommendation

Please submit three letters of reference when applying to this position. You may upload these directly to your application or have them sent to psdrecruit@ornl.gov.

About ORNL

As a U.S. Department of Energy (DOE) Office of Science national laboratory, ORNL has a long legacy of addressing the nation’s most pressing challenges. Our team is made up of over 7,000 dedicated and innovative individuals. Our goal is to create an environment where a variety of perspectives and backgrounds are valued, ensuring ORNL is known as a top choice for employment. ORNL offers competitive pay and benefits programs to attract and retain individuals who demonstrate exceptional work behaviors. The laboratory provides a range of employee benefits, including medical and retirement plans and flexible work hours, to support the well-being of you and your family. Employee amenities include on-site fitness, banking, and cafeteria facilities. Other benefits include a Prescription Drug Plan, Dental Plan, Vision Plan, 401(k) Retirement Plan, Contributory Pension Plan, Life Insurance, Disability Benefits, Generous Vacation and Holidays, Parental Leave, Legal Insurance with Identity Theft Protection, Employee Assistance Plan, Flexible Spending Accounts, Health Savings Accounts, Wellness Programs, Educational Assistance, Relocation Assistance, and Employee Discounts.

Additional Information

If you have difficulty using the online application system or need an accommodation to apply due to a disability, please email: ORNLRecruiting@ornl.gov. This position will remain open for a minimum of 5 days after which it will close when a qualified candidate is identified and/or hired. We accept Word (.doc, .docx), Adobe (.pdf), Rich Text Format (.rtf), and HTML (.htm, .html) up to 5MB. Resumes from third party vendors will not be accepted; these resumes will be deleted and the candidates submitted will not be considered for employment. ORNL is an equal opportunity employer. All qualified applicants, including individuals with disabilities and protected veterans, are encouraged to apply. UT-Battelle is an E-Verify employer.

#J-18808-Ljbffr