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Senior Python Full Stack Developer Jobs in Des Moines, IA

Athene Holding Ltd.

AI Engineer

West Des Moines, IA · On-site

We're seeking a Full-Stack AI Engineer to help scale our next-generation AI capabilities across ... Proficiency in Python, REST APIs, React/Node.js, and cloud-native infrastructure (Docker, CI/CD)

GE Aerospace

AI/ML Software Engineer

Des Moines, IA

$95K - $140K/yr

Proven experience as a Full Stack Engineer with AI/ML background * The work involves using AWS ... Strong software development skills with proficiency in Python, JupyterHub, GitHub, Visual Studio ...

Berkshire Hathaway Energy

Sr Network Engineer

Urbandale, IA

$98K - $134K/yr

... stacking or chassisbased platforms, QoS, and highavailability access and distribution designs ... Demonstrated expertise in network automation and infrastructureascode practices using Python, YAML ...

Varsity Tutors

Web Development Tutor

Ames, IA · Remote

$40/hr

Ability to explain client-server architecture, MVC patterns, and authentication while preparing students for full-stack development roles and software engineering careers. * Conceptual Teaching ...

Verint Systems

Engineer, Software

Des Moines, IA

You will design and build full-stack features end-to-end, write high-quality automated tests, support production systems, and collaborate daily with Product Managers, Designers, QA Engineers, and ...

Datavant

Senior Software Engineer

Des Moines, IA

$180K - $220K/yr

Mentor engineers at multiple levels and enhance team culture through best practices. Tech Stack You ... Python, Go, Java; microservices; REST and GraphQL * Frontend: TypeScript, React, Next.js

Varsity Tutors

JavaScript Tutor

Ames, IA · Remote

$40/hr

Ability to explain callback functions, scope and hoisting, and the event loop while preparing students for web development careers and full-stack engineering coursework. * Conceptual Teaching ...

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Senior Python Full Stack Developer information

See Des Moines, IA salary details

$58.1K

$126.7K

$179.1K

How much do senior python full stack developer jobs pay per year?

As of Jun 18, 2026, the average yearly pay for senior python full stack developer in Des Moines, IA is $126,676.00, according to ZipRecruiter salary data. Most workers in this role earn between $106,400.00 and $147,400.00 per year, depending on experience, location, and employer.

How much does a senior Python developer make?

A senior Python full stack developer typically earns between $100,000 and $150,000 annually, depending on experience, location, and company size. Skilled developers with expertise in frameworks like Django or Flask and experience with front-end technologies tend to command higher salaries.

What are the key skills and qualifications needed to thrive as a Senior Python Full Stack Developer, and why are they important?

To thrive as a Senior Python Full Stack Developer, you need advanced proficiency in Python, JavaScript frameworks (such as React or Angular), database management, and a solid understanding of both front-end and back-end development principles, often backed by a degree in computer science or related experience. Familiarity with tools like Django or Flask, RESTful APIs, version control systems (e.g., Git), and cloud platforms is typically required. Excellent problem-solving abilities, effective communication, and the ability to mentor junior developers are standout soft skills for this role. These skills ensure robust, scalable applications and foster effective collaboration across technical teams, driving project success.

What is the difference between Senior Python Full Stack Developer vs Backend Developer?

AspectSenior Python Full Stack DeveloperBackend Developer
Required SkillsProficiency in Python, JavaScript, HTML/CSS, frameworks like Django/Flask, React or AngularStrong Python skills, experience with server-side development, databases, APIs
Work EnvironmentFull-stack development across front-end and back-end, often in agile teamsPrimarily server-side, database, and API development
Industry UsageTech companies, startups, enterprises needing full-stack solutionsWeb services, SaaS, enterprise applications

The main difference is that a Senior Python Full Stack Developer handles both front-end and back-end development, requiring skills in multiple technologies, while a Backend Developer focuses mainly on server-side logic, databases, and APIs. The full-stack role demands broader expertise, whereas backend roles are more specialized in server-side development.

What are Senior Python Full Stack Developers?

Senior Python Full Stack Developers are experienced software engineers who specialize in both frontend and backend web development using Python and related technologies. They are responsible for designing, building, and maintaining complex web applications, often leading teams and making architectural decisions. Their expertise typically includes frameworks like Django or Flask for backend development, as well as JavaScript frameworks such as React or Angular for the frontend. In addition to coding, they often mentor junior developers and ensure best practices in software development. Their role requires a deep understanding of databases, APIs, deployment processes, and modern development workflows.

What are some common challenges faced by Senior Python Full Stack Developers when working on cross-functional teams?

Senior Python Full Stack Developers often collaborate with designers, product managers, and DevOps specialists, which can present challenges in aligning technical solutions with business goals and user experience expectations. Balancing backend performance with frontend responsiveness and maintaining clear communication across disciplines are key hurdles. Additionally, staying updated with rapidly evolving frameworks and ensuring code quality and scalability across the stack requires continual learning and adaptability. Successful developers proactively bridge these gaps by fostering open dialogue and advocating for best practices throughout the development process.

Is there demand for Python full stack developer?

The demand for Python full stack developers remains strong due to the language's versatility in web development, data analysis, and automation. Companies seek professionals skilled in frameworks like Django and Flask, along with front-end technologies, to build comprehensive applications. Proficiency in related tools and continuous learning can enhance job prospects in this field.

Which pays more, C++ or Python?

For a Senior Python Full Stack Developer, Python skills generally command higher salaries due to its widespread use in web development, data science, and automation. C++ developers may earn more in specialized fields like systems programming or game development, but overall Python offers higher average compensation for full stack roles. Salary differences depend on industry, experience, and location.

Is Python full-stack in demand in 2026?

Python full-stack development remains in high demand in 2026 due to its versatility, with companies seeking developers skilled in frameworks like Django and Flask, as well as front-end technologies. Strong knowledge of databases, APIs, and version control tools enhances employability in this role.
What are popular job titles related to Senior Python Full Stack Developer jobs in Des Moines, IA? For Senior Python Full Stack Developer jobs in Des Moines, IA, the most frequently searched job titles are:
What job categories do people searching Senior Python Full Stack Developer jobs in Des Moines, IA look for? The top searched job categories for Senior Python Full Stack Developer jobs in Des Moines, IA are:
Senior Python Full Stack Developer jobs near you

AI Engineer

Athene Holding Ltd.

West Des Moines, IA • On-site

Full-time

Posted 18 days ago

Job description

We are driven to do more. More for our customers and the financial professionals who offer our products. If you are driven to do more and love the challenge of pursuing more, Athene is your kind of company. You will find we offer more than the basics to create an inclusive and dynamic work environment at our various locations.
Purpose:
Athene is accelerating its AI initiatives by hiring multiple AI Engineers to transform how we serve customers, agents, and business partners. As a leader in insurance and annuities, we are committed to applying Generative AI, Agentic AI, and Machine Learning to drive operational excellence and deliver innovative products.
We're seeking a Full-Stack AI Engineer to help scale our next-generation AI capabilities across sales, marketing, finance, risk management, product development, claims, and enterprise productivity. You'll join a small, cross-functional team building AI-native solutions from the ground up-rapidly prototyping, experimenting with new capabilities, and moving fast from concept to production.
This is a high-impact role where you'll collaborate with designers, product managers, and engineers in a maker-driven environment. You'll work hands-on with Generative AI and intelligent agents, both in the features we deliver and in your daily development workflow.
Accountabilities:
  • Build, deploy, and optimize full-stack AI-powered applications using LLMs, intelligent agents, and ML.
  • Design and scale RAG pipelines, vector search systems, and LLM evaluation workflows.
  • Create AI agents with frameworks such as LangChain, AutoGen, LlamaIndex, or LangGraph.
  • Ingest and process unstructured/structured data (parsing, chunking, embeddings, retrieval).
  • Develop intuitive user experiences powered by LLMs and AI agents for real-time workflows.
  • Integrate enterprise AI tools such as Claude, GPT-4/4o, ChatGPT Enterprise, Copilot, Glean, and Shelf.
  • Drive document automation and multilingual NLP (summarization, translation, NER).
  • Implement observability, governance, and responsible AI practices in compliance with regulations.
  • Collaborate with IT, data, compliance, and business leaders to deliver business-facing solutions.

Qualifications and Experience:
  • Bachelor's degree in computer science, Engineering, or related field (or equivalent experience).
  • 5+ years in software engineering or data science, with 1+ year in GenAI/LLM/Agentic AI.
  • Proficiency in Python, REST APIs, React/Node.js, and cloud-native infrastructure (Docker, CI/CD).
  • Hands-on experience with AWS AI services (Bedrock, SageMaker, Textract, Translate, etc.).
  • Strong knowledge of LLMs, embeddings, prompt engineering, and tool use.
  • Proven ability to prototype, iterate, and scale AI-enabled features.
  • Familiarity with compliance/regulatory needs in insurance or financial services (preferred).
  • AI-first developer mindset: using AI for scaffolding, testing, and refactoring code.

Drive. Discipline. Confidence. Focus. Commitment. Learn more about working at Athene.
Athene is a Military Friendly Employer! Learn more about how we support our Veterans.
Athene is committed to inclusion and is proud to be an Equal Opportunity Employer. We do not discriminate on the basis of race, color, religion, sex, national origin, age, disability, marital status, sexual orientation, veteran status or any other status protected by federal, state or local law.

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