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Senior Python Engineer Jobs in Irvine, CA (NOW HIRING)

IT Associates, Inc.

Senior Observability Engineer

Irvine, CA · On-site

$112K - $154K/yr

As a Senior Observability Engineer, you will be responsible for designing, implementing, migrating ... Experience in Python, Bash, PowerShell or JavaScript for automation of tasks. * Exposure to CI/CD ...

Masimo

Sr Engineer, AI/Machine Learning

Irvine, CA · On-site

$140K - $170K/yr

The Sr Engineer, AI & ML will be part of the R&D team at Masimo with focus on design and creation ... Strong programming skills in MATLAB/Python/C/C++ and exposure to software engineering methods

Masimo

Sr Engineer, AI/Machine Learning

Irvine, CA · On-site

$140K - $170K/yr

The Sr Engineer, AI & ML will be part of the R&D team at Masimo with focus on design and creation ... Strong programming skills in MATLAB/Python/C/C++ and exposure to software engineering methods

Vast

Senior Systems Engineer

Long Beach, CA · On-site

$137K - $195K/yr

Strong scripting and data analysis skills (Python, MATLAB, Excel) and familiarity with ... Senior Systems Engineer: $137,760 - $195,552 * Staff Systems Engineer: $162,360 - $230,472

Abode TechZone, LLC

Sr. Database Engineer

Irvine, CA · On-site

$112K - $152K/yr

Abode TechZone, LLC is seeking a Sr. Database Engineer to lead the design of high-performance data ... mastery of Python and Advanced SQL for automation and sophisticated data manipulation • Deep ...

EKN Engineering

Sr. DevOps Engineer

Irvine, CA · On-site

$139K - $179K/yr

Senior DevOps Engineer At EKN Engineering, we solve challenging problems with innovative ... such as TypeScript or Python * Experience designing and operating monitoring, logging, and ...

Doist

Senior Software Engineer

Irvine, CA · On-site

$140 - $190/hr

About the Job As a Senior Software Engineer, help build and scale a category-defining healthcare data platform and you will have experience in Elixir and/or Python. You will play a critical role in ...

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Senior Python Engineer information

See Irvine, CA salary details

$59K

$152.4K

$209.3K

How much do senior python engineer jobs pay per year?

As of Aug 19, 2026, the average yearly pay for senior python engineer in Irvine, CA is $152,395.00, according to ZipRecruiter salary data. Most workers in this role earn between $130,400.00 and $175,500.00 per year, depending on experience, location, and employer.

What does a senior Python engineer do?

A Senior Python Engineer is an experienced software developer who specializes in designing, developing, and maintaining applications using the Python programming language. They often take on leadership roles within development teams, contribute to architectural decisions, and mentor junior engineers. Senior Python Engineers work on complex projects, ensure code quality, and help implement best practices to improve efficiency and reliability. Their work may span back-end development, data engineering, automation, and integrating with other technologies.

What are the key skills and qualifications needed to thrive as a senior Python engineer, and why are they important?

To thrive as a Senior Python Engineer, you need expert knowledge of Python programming, software architecture, and experience with web frameworks, supported by a degree in computer science or related field. Familiarity with tools like Django, Flask, REST APIs, Docker, and version control systems such as Git is typically required, along with possible certifications in cloud technologies or Python itself. Strong problem-solving abilities, leadership, and effective communication skills help you lead teams and collaborate across departments. These skills ensure robust, scalable software solutions and foster innovation and efficiency within development projects.

What are the common challenges senior Python engineers face when leading projects, and how can they effectively address them?

Senior Python Engineers often encounter challenges such as balancing hands-on coding with overseeing project architecture, mentoring junior developers, and ensuring code quality across the team. Effectively addressing these challenges involves strong communication, setting clear coding standards, and fostering a collaborative environment through regular code reviews and knowledge-sharing sessions. Staying updated on best practices and leveraging automation tools for testing and deployment can also help streamline workflows and maintain high-quality deliverables.

What are popular job titles related to Senior Python Engineer jobs in Irvine, CA?

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Cities near Irvine, CA with the most Senior Python Engineer job openings:

Senior Python Engineer jobs near you
Infographic showing various Senior Python Engineer job openings in Irvine, CA as of August 2026, with employment types broken down into 91% Full Time, 5% Part Time, and 4% Contract. Highlights an 87% Physical, 5% Hybrid, and 8% Remote job distribution, with an average salary of $152,395 per year, or $73.3 per hour.

Hybrid - Senior AI Engineer -Irvine, CA- Fulltime

Ztek Consulting INC

Irvine, CA • On-site

$120K - $130K/yr

Full-time

Re-posted 13 days ago

Job description

Hello ,

This is Pankaj Pagare from Ztek Consulting INC (www.ztekinc.com) .

We do have a position for Senior AI Engineer

Please find the details below and if interested please send me your updated word format resume.

Job Title: Senior AI Engineer

Location: Irvine, CA(Hybrid)

Position Type: Fulltime

Experience Required:8+

 

Job Description

Must have Technical skills:

  • 5+ years of experience in software engineering, data engineering, or AI/ML engineering
  • Strong proficiency in Python for AI/data workflows and automation
  • Hands-on experience building solutions in AWS cloud environments
  • Experience with:
    • Databricks (or similar) and Apache Spark for distributed data processing
    • OpenSearch / Elasticsearch (including vector search)
    • Graph databases (Neptune or similar)
    • DynamoDB and Redis/ElastiCache
  • Experience building backend services and APIs (e.g., Java/Spring Boot, Node.js)
  • Production experience with Docker and Kubernetes
  • Experience with CI/CD pipelines and deployment automation
  • Strong understanding of distributed systems, data architecture, and scalable design

Preferred Qualifications

  • Experience with LLM/GenAI architectures (RAG, embeddings, prompt engineering)
  • Familiarity with LangGraph, AutoGen, CrewAI, or similar agent orchestration frameworks
  • Experience with LangChain or LlamaIndex
  • Experience implementing LLM evaluation and observability frameworks
  • Familiarity with AI security practices and threat models (prompt injection, guardrails)
  • Experience working in regulated environments with strong data governance and compliance requirements

Tech Stack

  • AWS: Neptune, OpenSearch, DynamoDB, ElastiCache (Redis), IAM, CloudWatch
  • Data: Databricks, Apache Spark
  • AI: LLM integrations, embeddings, vector search, RAG pipelines
  • Agentic/LLM Tooling: LangChain, LlamaIndex, LangGraph, AutoGen, CrewAI
  • Backend: APIs, microservices (e.g., Spring Boot, Node.js)
  • DevOps: Docker, Kubernetes, CI/CD, Infrastructure as Code

Thanks and Regards,
Pankaj Pagare
Ztek Consulting Inc.,        

Phone: 1 678-918-5069

E-mail: Pankaj@ztekinc.com

Visit us at www.ztek-inc.com