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Senior Python Developer Jobs in Palmdale, CA (NOW HIRING)

Senior AI Engineering

Pasadena, CA

$114K - $156K/yr

Build production-grade services and APIs using Python, FastAPI or Flask, Azure OpenAI, Azure ML ... Integrate AI capabilities into enterprise applications, developer workflows, knowledge management ...

Build production-grade services and APIs using Python, FastAPI or Flask, Azure OpenAI, Azure ML ... Integrate AI capabilities into enterprise applications, developer workflows, knowledge management ...

Sr. Software Developer

California City, CA

$66.75 - $88.25/hr

Java/J2EE; python; Jenkins Strong RDBMs and NoSQL skills Job Responsibilities: * Developing cutting ... Proficient with Java programming languages * Proficient with Spring Framework * Proficient with ...

Design Engineer III

Burbank, CA · On-site

$111K - $153K/yr

Senior plc is an international, market-leading, engineering solutions provider with 19 operating ... Python, and the API of applicable calculation software. * Internal flow calculations and external ...

Machina Labs is seeking a Senior DevOps Engineer to join our growing software engineering team and ... Familiarity with Python and/or JavaScript to support automation, tooling, or platform integration.

Senior DevOps Engineer

Chatsworth, CA · On-site

$155K - $185K/yr

Machina Labs is seeking a Senior DevOps Engineer to join our growing software engineering team and ... Familiarity with Python and/or JavaScript to support automation, tooling, or platform integration.

Senior Security Engineer

Los Angeles, CA · Hybrid

$123K - $169K/yr

The role of a Senior Security Engineer in 2026 has evolved from a traditional "firewall gatekeeper ... Engineering Proficiency in Python, Go, or Rust for building custom security tooling and automation.

Senior Security Engineer

Los Angeles, CA · On-site +1

$123K - $169K/yr

The role of a Senior Security Engineer in 2026 has evolved from a traditional "firewall gatekeeper ... Engineering Proficiency in Python, Go, or Rust for building custom security tooling and automation.

Senior Software Engineer

Los Angeles, CA · On-site

$160K - $190K/yr

Senior Software Engineer We're looking for a full-time Senior Software Engineer to join us in our ... Use AI-augmented workflows (Claude) to build and deploy full-stack features using Python (Backend ...

Senior Software Engineer

Los Angeles, CA · On-site

$160K - $190K/yr

Senior Software Engineer We're looking for a full-time Senior Software Engineer to join us in our ... Use AI-augmented workflows (Claude) to build and deploy full-stack features using Python (Backend ...

Senior Software Engineer

South Pasadena, CA · Hybrid

$132K - $174K/yr

Elementary is seeking an experienced python Senior Software Engineer. If you want to deploy and run cutting edge AI algorithms on real production lines with strict timing requirements, this is the ...

Sr Software Engineer

Glendale, CA · On-site

$135K - $181K/yr

Job Posting Title: Sr Software Engineer Req ID: 10149383 At Disney "We Power the Magic!" That's our ... Excellent programming skills in languages Java and Python. * Experience with cloud platforms (AWS ...

Senior Data Engineer

Los Angeles, CA · Remote

$114K - $155K/yr

The Senior Data Engineer is responsible for analyzing, validating, cleansing, and performing ETL of ... Creating Python scripts to automate internal tasks. * Creating Power Automate and Power Apps ...

Senior Sales Engineer

Los Angeles, CA · Remote

$220K - $250K/yr

The Opportunity As a Senior Sales Engineer, you will bridge the gap between go-to-market and ... CS/engineering degree with strong technical fluency, including Python backend development skills ...

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Showing results 1-20

Senior Python Developer information

See Palmdale, CA salary details

$58.8K

$151.8K

$208.4K

How much do senior python developer jobs pay per year?

As of Jul 14, 2026, the average yearly pay for senior python developer in Palmdale, CA is $151,756.00, according to ZipRecruiter salary data. Most workers in this role earn between $129,900.00 and $174,800.00 per year, depending on experience, location, and employer.

What are the main responsibilities of a Senior Python Developer?

A Senior Python Developer is responsible for designing, developing, and maintaining complex software applications using the Python programming language. They lead the technical aspects of projects, mentor junior developers, and ensure code quality through code reviews and best practices. Additionally, they collaborate with cross-functional teams to gather requirements, solve technical challenges, and deploy scalable and efficient solutions. Senior Python Developers are also expected to stay updated with the latest trends and advancements in Python and related technologies.

What is the difference between Senior Python Developer vs Python Developer?

AspectSenior Python DeveloperPython Developer
Required ExperienceTypically 5+ years, with leadership and complex project experienceUsually 1-3 years, focusing on core Python skills
ResponsibilitiesDesigning architecture, mentoring, handling complex systemsWriting code, debugging, implementing features
CertificationsOptional but beneficial (e.g., Python certifications, cloud certs)Often not required
Work EnvironmentCollaborative teams, project planning, code reviewsDevelopment-focused, task-oriented

The main difference between a Senior Python Developer and a Python Developer lies in experience, responsibilities, and leadership. Senior developers handle complex projects, mentor others, and often participate in architecture decisions, while Python Developers focus on coding and feature implementation. Both roles are essential in tech companies, but the senior role requires more experience and broader skills.

What are the key skills and qualifications needed to thrive as a Senior Python Developer, and why are they important?

To thrive as a Senior Python Developer, you need advanced proficiency in Python programming, experience with software architecture, and a solid understanding of algorithms and data structures, usually backed by a degree in computer science or related fields. Familiarity with frameworks like Django or Flask, version control systems such as Git, and containerization tools like Docker are typically required, alongside knowledge of modern CI/CD pipelines. Strong problem-solving abilities, effective communication, and leadership skills help you collaborate with teams and mentor junior developers. Mastery of these skills ensures the delivery of scalable, maintainable software solutions and the ability to drive technical excellence within development teams.

What are some common challenges faced by Senior Python Developers when leading a development team?

Senior Python Developers often encounter challenges such as balancing hands-on coding with mentoring junior team members and ensuring code quality across the team. They are also responsible for making architectural decisions, which requires staying updated on best practices and emerging Python frameworks. Additionally, coordinating collaboration between cross-functional teams (like DevOps, QA, and front-end developers) can be complex, especially in agile environments where requirements may shift rapidly. Overcoming these challenges helps foster a productive and innovative team culture.
What are popular job titles related to Senior Python Developer jobs in Palmdale, CA? For Senior Python Developer jobs in Palmdale, CA, the most frequently searched job titles are:
What job categories do people searching Senior Python Developer jobs in Palmdale, CA look for? The top searched job categories for Senior Python Developer jobs in Palmdale, CA are:
What cities near Palmdale, CA are hiring for Senior Python Developer jobs? Cities near Palmdale, CA with the most Senior Python Developer job openings:
Senior AI Engineering

$114K - $156K/yr

Full-time

Posted 9 days ago


Job description

Since 1973, East West Bank has served as a pathway to success. With over 110 locations across the U.S. and Asia, we are the premier financial bridge between the East and West. Our teams of experienced, multi-cultural professionals help guide businesses and community members on both sides of the Pacific looking to explore new markets and create new opportunities, and our sustained growth and expertise in industries like real estate, entertainment and media, private equity and venture capital, and high-tech help build sustainable businesses and expand our associates’ potential for career advancement. 

Headquartered in California, East West Bank (Nasdaq: EWBC) is a top-performing commercial bank with a strong foundation, an enterprising spirit and a commitment to absolute integrity. East West Bank gives people the confidence to reach further.


East West Bank is seeking an experienced Senior AI Engineering to design, build, and operationalize enterprise-grade AI and Generative AI solutions across the Bank. This senior technical leader will translate emerging AI capabilities into secure, scalable, production-ready banking applications that improve operational efficiency, risk management, customer experience, and employee productivity.

The role is expected to be hands-on at the outset while helping establish foundational AI engineering capabilities, operating standards, and a small, high-performing AI engineering team.


  • Design, develop, and deploy enterprise AI and Generative AI applications for prioritized banking use cases (e.g., customer service, fraud detection, document processing, knowledge management, and operational efficiency)
  • Architect LLM-enabled solutions spanning retrieval-augmented generation, vector search, agentic workflows, MCP, model orchestration, tool/function calling, and human-in-the-loop controls.
  • Build production-grade services and APIs using Python, FastAPI or Flask, Azure OpenAI, Azure ML, Databricks, ADLS, and modern cloud-native patterns.
  • Integrate AI capabilities into enterprise applications, developer workflows, knowledge management platforms, automation, analytics, and decision-support processes.
  • Establish engineering practices for CI/CD, testing, model evaluation, observability, performance optimization, security, and responsible AI controls.
  • Establish reusable AI engineering frameworks, reference architectures, code standards, deployment patterns, and governance controls to accelerate enterprise adoption.
  • Partner with business, data, cybersecurity, risk, compliance, legal, and vendor teams to ensure solutions meet regulatory, privacy, auditability, and operational risk expectations.
  • Prototype rapidly with stakeholders, convert pilots into scalable implementations, and define measurable adoption and impact metrics.
  • Evaluate LLM platforms for accuracy, latency, cost, security, explainability, and fit for regulated enterprise use cases.
  • Support hiring, mentoring, and day-to-day technical leadership of AI engineers and cross-functional delivery teams.
  • Stay current with emerging AI technologies and advise leadership on practical opportunities, risks, and implementation tradeoffs.
  • Perform other duties as assigned.

AI Fluency & Hands-On LLM Skills

  • Hands-on experience with major LLM platforms, including OpenAI ChatGPT/Codex, Anthropic Claude, Google Gemini, Microsoft Copilot/Azure OpenAI, AWS Bedrock, and open-source models such as Llama or Mistral.
  • Practical experience with prompt engineering, RAG, embeddings, vector databases, LLM orchestration frameworks, agentic workflows, evaluation frameworks, and hallucination mitigation.
  • Ability to design AI applications that include data protection, source validation, access control, logging, monitoring, traceability, and human review where appropriate.
  • Strong understanding of Responsible AI, model governance, prompt-injection risks, data privacy, and production controls for LLM-enabled solutions.

  • Bachelor's degree in Computer Science, Engineering, Data Science, AI/ML, or equivalent practical experience; advanced degree preferred.
  • 10+ years of progressive experience in software engineering, AI engineering, platform engineering or related technology leadership roles, including experience delivering production AI solutions
  • Proven experience leading AI, data, automation, or emerging technology initiatives from strategy and experimentation through production delivery.
  • Strong hands-on engineering background in Python, API design, microservices, cloud architecture, distributed systems, data pipelines, CI/CD, testing, observability, and secure software delivery.
  • Deep experience with the Azure ecosystem, including Azure OpenAI, Azure ML, Databricks, ADLS, Azure AI Search, and related enterprise integration patterns.
  • Experience with LLM frameworks and tooling such as LangChain, LlamaIndex, Semantic Kernel, vector databases, model registries, evaluation frameworks, and monitoring/observability tools.
  • Strong process and data discipline, including data quality, lineage, metadata, workflow design, controls, operational risk, and measurable business outcomes.
  • Experience in financial services, banking, fintech, insurance, or another regulated industry with strong understanding of compliance, auditability, risk management, and governance.
  • Ability to lead cross-functional teams, influence senior stakeholders, mentor engineers, and translate complex AI capabilities into practical business solutions.
  • Strong executive communication skills, including the ability to define AI roadmaps, operating models, standards, adoption plans, and success metrics.

Preferred Qualifications

  • Master's degree in AI, Computer Science, Data Science, Engineering, or a related field.
  • Experience establishing AI engineering teams, platforms, reusable delivery patterns, and enterprise AI standards.
  • Experience with copilots, enterprise search, intelligent document processing, workflow automation, and AI-enabled knowledge management.
  • Experience driving AI vendor evaluation and selection processes within regulated environments
  • Familiarity with model risk management, third-party/vendor risk, privacy impact assessments, and regulated technology delivery.
  • Experience with MLOps/LLMOps, AI monitoring, evaluation pipelines, model/prompt registries, and production incident management.
  • Track record of mentoring senior engineers and building high-performing technical teams.

Applicants must have legal authorization to work in the United States.  We do not offer visa sponsorship at this time.  


The base pay range for this position is USD $150,000.00/Yr. - USD $275,000.00/Yr. Exact offers will be determined based on job-related knowledge, skills, experience, and location.