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Senior Python Developer Jobs in Mississippi (NOW HIRING)

Principal Software Engineer (Python)

Oxford, MS · On-site +1

$127K - $170K/yr

This senior-level position is responsible for creating scalable, high-quality software solutions ... Expert Python/FastAPI Developer: Proven experience in designing, scaling, and maintaining existing ...

Senior AI Engineer

Biloxi, MS · On-site

$93K - $127K/yr

The Senior AI Engineer is responsible for designing, developing, and deploying enterprise-grade ... Strong programming skills in Python and SQL. * Ability to evaluate build vs buy vs integrate ...

$38 - $51.25/hr

The Senior OutSystems Developer is expected to be highly driven to achieve results, with a strong ... NET, Java, JavaScript, or Python * Development and ongoing support of enterprise grade applications

Senior Cloud Engineer

Jackson, MS · On-site

$48.50 - $65/hr

Senior Cloud Engineer Location: Jackson, MS 39201 Work Arrangement: Onsite Mode of Interview: Video ... Experience with automation and scripting languages like Python, Bash, or PowerShell. Understanding ...

DevOps Engineer

Jackson, MS · On-site

$46 - $63/hr

They are seeking a talented and highly effective Senior DevOps Engineer to support, enhance, and ... Bash, Python, Ruby, Perl • Subversion (SVN), GIT, GIT Hub • Database Systems/Database Tools ...

Senior Electrical Engineer

Mchenry, MS · On-site

$92K - $120K/yr

ABOUT THE JOB As the Sr. Electrical Engineer, you will specify, design, develop and install devices ... Ability to write and understand Python * Eligible to obtain and maintain an active U.S. Secret ...

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Senior Python Developer information

See Mississippi salary details

$52.1K

$134.5K

$184.7K

How much do senior python developer jobs pay per year?

As of Sep 10, 2026, the average yearly pay for senior python developer in Mississippi is $134,461.00, according to ZipRecruiter salary data. Most workers in this role earn between $115,100.00 and $154,800.00 per year, depending on experience, location, and employer.

What are the main responsibilities of a senior Python developer?

A Senior Python Developer is responsible for designing, developing, and maintaining complex software applications using the Python programming language. They lead the technical aspects of projects, mentor junior developers, and ensure code quality through code reviews and best practices. Additionally, they collaborate with cross-functional teams to gather requirements, solve technical challenges, and deploy scalable and efficient solutions. Senior Python Developers are also expected to stay updated with the latest trends and advancements in Python and related technologies.

What are the key skills and qualifications needed to thrive as a senior Python developer?

To thrive as a Senior Python Developer, you need advanced proficiency in Python programming, experience with software architecture, and a solid understanding of algorithms and data structures, usually backed by a degree in computer science or related fields. Familiarity with frameworks like Django or Flask, version control systems such as Git, and containerization tools like Docker are typically required, alongside knowledge of modern CI/CD pipelines. Strong problem-solving abilities, effective communication, and leadership skills help you collaborate with teams and mentor junior developers. Mastery of these skills ensures the delivery of scalable, maintainable software solutions and the ability to drive technical excellence within development teams.

What are some common challenges faced by senior Python developers when leading a development team?

Senior Python Developers often encounter challenges such as balancing hands-on coding with mentoring junior team members and ensuring code quality across the team. They are also responsible for making architectural decisions, which requires staying updated on best practices and emerging Python frameworks. Additionally, coordinating collaboration between cross-functional teams (like DevOps, QA, and front-end developers) can be complex, especially in agile environments where requirements may shift rapidly. Overcoming these challenges helps foster a productive and innovative team culture.

What is the difference between Senior Python Developer vs Python Developer?

AspectSenior Python DeveloperPython Developer
Required ExperienceTypically 5+ years, with leadership and complex project experienceUsually 1-3 years, focusing on core Python skills
ResponsibilitiesDesigning architecture, mentoring, handling complex systemsWriting code, debugging, implementing features
CertificationsOptional but beneficial (e.g., Python certifications, cloud certs)Often not required
Work EnvironmentCollaborative teams, project planning, code reviewsDevelopment-focused, task-oriented

The main difference between a Senior Python Developer and a Python Developer lies in experience, responsibilities, and leadership. Senior developers handle complex projects, mentor others, and often participate in architecture decisions, while Python Developers focus on coding and feature implementation. Both roles are essential in tech companies, but the senior role requires more experience and broader skills.

Are senior Python developers still in demand?

Senior Python developers remain in high demand due to the language's versatility in web development, data analysis, machine learning, and automation. Companies seek experienced developers with skills in frameworks like Django or Flask, and proficiency in cloud platforms and APIs enhances job prospects.

How much does a senior Python developer make?

A senior Python developer typically earns between $100,000 and $150,000 annually, depending on experience, location, and industry. They often possess strong skills in frameworks like Django or Flask and may hold certifications or advanced degrees that influence salary levels.

What does a senior Python developer do?

A senior Python developer designs, develops, and maintains complex software applications using Python. They often lead projects, review code, optimize performance, and collaborate with cross-functional teams, requiring strong problem-solving skills and knowledge of frameworks like Django or Flask. Additionally, they may mentor junior developers and ensure code quality through testing and best practices.

What are the most commonly searched types of Python Developer jobs in Mississippi?

The most popular types of Python Developer jobs in Mississippi are:

What are popular job titles related to Senior Python Developer jobs in Mississippi?

For Senior Python Developer jobs in Mississippi, the most frequently searched job titles are:

What job categories do people searching Senior Python Developer jobs in Mississippi look for?

The top searched job categories for Senior Python Developer jobs in Mississippi are:

What cities in Mississippi are hiring for Senior Python Developer jobs?

Cities in Mississippi with the most Senior Python Developer job openings:

What are popular job titles related to Senior Python Developer jobs in MS?

For Senior Python Developer jobs in MS, the most frequently searched job titles are:

Infographic showing various Senior Python Developer job openings in Mississippi as of August 2026, with employment types broken down into 1% Internship, 86% Full Time, 8% Part Time, and 5% Contract. Highlights an 79% Physical, 6% Hybrid, and 15% Remote job distribution, with an average salary of $134,461 per year, or $64.6 per hour.

Principal Software Engineer (Python)

Oxford, MS • On-site, Remote

$127K - $170K/yr

Full-time

Medical, Life, Retirement, PTO

Re-posted yesterday


Key responsibilities

  • Lead the design, development, and scaling of the Semantic Layer Web Service to automate attribute management and enable enterprise intelligence.

  • Serve as the primary technical lead for Knowledge Representation and Semantic Search, ensuring system performance and architectural integrity.

  • Design and deploy advanced reasoning architectures, develop robust backend AI services, and collaborate on automating metadata ingestion and system evaluation.


Job description

At Cotality, we are driven by a single mission-to make the property industry faster, smarter, and more people-centric. Cotality is the trusted source for property intelligence, with unmatched precision, depth, breadth, and insights across the entire ecosystem. Our talented team of 5,000 employees globally uses our network, scale, connectivity and technology to drive the largest asset class in the world. Join us as we work toward our vision of fueling a thriving global property ecosystem and a more resilient society.

Cotality is committed to cultivating a diverse and inclusive work culture that inspires innovation and bold thinking; it's a place where you can collaborate, feel valued, develop skills and directly impact the real estate economy. We know our people are our greatest asset. At Cotality, you can be yourself, lift people up and make an impact. By putting clients first and continuously innovating, we're working together to set the pace for unlocking new possibilities that better serve the property industry.

Job Description:

The hybrid-remote Principal Software Development Engineer leads the design, development, and testing of complex software systems and applications. This senior-level position is responsible for creating scalable, high-quality software solutions while providing technical leadership, driving engineering excellence, and providing mentorship to engineering teams.

The Mission: You will take the helm of our existing Semantic Layer Web Service and lead its evolution into a high-scale, automated intelligence platform. Your mission is to break the current manual bottlenecks-moving the service from 130 manually curated attributes to a system capable of managing thousands. You will bridge the gap between "boutique" internal tools and a fully automated, GraphRAG-enabled enterprise ecosystem.

Job Responsibilities:

  • Architect and Evolve the Semantic Layer: Lead the redesign and scaling of the existing Semantic Layer Web Service, transitioning it from a manual 130-attribute baseline to an automated, high-availability enterprise intelligence platform.

  • Take the Team Anchor Role: Serve as the primary technical lead for the delivery team, owning the architectural vision for Knowledge Representation and Semantic Search while ensuring "fiduciary-grade" performance as the system scales to 1,000+ attributes.

  • Implement Advanced Reasoning: Design and deploy Hybrid Graph/Vector search architectures (GraphRAG) to enable complex global reasoning across disparate enterprise data assets.

  • Develop High-Performance AI Services: Utilize Git or similar, Unix command line, Python, FastAPI, FastMCP, and ADK to build and enhance robust backend services that bridge core enterprise data with Agentic AI.

  • Model Optimization (LLM & SLM): Partner with the Data Science team to architect intelligent routing logic that leverages Small Language Models (SLMs) for high-speed classification/extraction and Large Language Models (LLMs) for complex synthesis.

  • Automate Metadata Ingestion: Collaborate with the Knowledge Engineering team to build automated workflows for Ontology Management and Entity Linking, eliminating single-resource bottlenecks and manual curation constraints.

  • Establish Systematic Evaluation: Collaborate with Knowledge Engineering and Data Science teams to replace "vibe checks" with rigorous automated testing frameworks, utilizing metrics like Faithfulness, Answer Relevance, and Context Precision (RAGAS) to ensure quality during rapid scaling.

  • Conduct Expert Code Reviews: Ensure high code quality, adherence to AI engineering standards, and architectural integrity across the Python/AI stack.

  • Drive Test-Driven Development (TDD): Implement rigorous TDD practices, writing comprehensive unit and integration tests to ensure the reliability of non-deterministic semantic pipelines.

  • Apply Advanced Algorithms: Utilize specialized algorithms for Entity Disambiguation and Ontology Evolution to solve complex knowledge-graph scaling and schema-drift challenges.

  • Optimize Performance and Scalability: Independently plan and execute system optimizations to ensure the Semantic Layer remains performant under enterprise-scale loads and high-dimensional search requirements.

  • Troubleshoot Complex AI Issues: Resolve deep technical challenges related to model hallucinations, "Lost in the Middle" context window phenomena, and retrieval latency.

  • Stay Updated on Emerging AI Trends: Monitor and provide recommendations on the rapidly evolving AI landscape, including SLM success areas, prompt engineering, and synthetic data generation.

  • Mentor Senior & Junior Engineers: Act as a technical mentor and coach, sharing expertise in Python, Semantic AI, and Cloud Architecture to upskill the broader engineering organization.

Job Qualifications:

  • Education & Experience: Master's or Bachelor's degree in Computer Science, AI, or a related field, with 10+ years of professional software engineering experience.

  • Expert Python/FastAPI Developer: Proven experience in designing, scaling, and maintaining existing production web services in an asynchronous Python environment.

  • Semantic & Graph Expertise: Deep understanding of Knowledge Representation, Ontologies, and Graph Reasoning; experience taking "boutique" internal tools and turning them into high-availability platforms.

  • Advanced RAG Knowledge: Professional experience with Vector Databases, Hybrid Search, and advanced retrieval strategies (e.g., Query Expansion, HyDE, and Reranking).

  • AI Orchestration Mastery: Advanced proficiency in ADK or similar model abstraction tools, with a strong grasp of the operational trade-offs between LLMs and SLMs.

  • Evaluation Rigor: Familiarity with AI evaluation frameworks (RAGAS, DeepEval) and the use of LLMs to generate synthetic testing suites for benchmarking.

  • Analytical & Scale-Minded: Strong ability to apply complex data structures and algorithms to solve scaling bottlenecks and non-deterministic logic problems.

  • Cloud Architecture: Experience deploying and managing scalable AI services in cloud environments (GCP, AWS, or Azure).

  • Communication & Leadership: Excellent communication skills with a track record of leading high-performing engineering PODs and collaborating with cross-functional stakeholders.

#LI-Hybrid

Annual Pay Range:

154,600 - 180,000 USD

Application Window:

This opportunity is expected to remain posted through the date identified below, subject to business needs.

Thrive with Cotality

At Cotality, we offer more than just a job, we provide a benefits experience designed to support your whole self. From a flexible working model to competitive time off and standout health coverage with meaningful perks and growth opportunities, our package is built to help you thrive at work and in life.

Highlights, depending on role classification, include:

  • Time off: Generous PTO and 11 paid holidays, plus well-being and volunteer time off.

  • Family Support: Up to 16 weeks of fully paid parental leave and a baby stipend.

  • Health: Multiple medical plan options with mental health and wellness support offerings.

  • Retirement: 401(k) with company match and vesting after one year.

  • Financial Perks: $400 annual well-being stipend and tuition assistance up to $5,250.

  • Extras: Recognition Rewards, Referral bonuses, exclusive discounts and more!

Cotality is an Equal Opportunityemployer committed to attracting and retaining thebest-qualified people available, without regard torace, color, religion, national origin, gender, sexualorientation, gender identity, age, disability or statusas a veteran of the Armed Forces, or any other basisprotected by federal, state or local law. Cotalitymaintains a Drug-Free Workplace.

Cotality is fully committed to a work environment that embraces everyone's uniquecontributions, experiences and values. We offer anempowered work environment that encouragescreativity, initiative and professional growth andprovides a competitive salary and benefits package. We are better together when we support and recognize our differences.

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