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Senior Python Developer Jobs in Kentucky (NOW HIRING)

Senior DevOps Engineer

Louisville, KY · On-site

$124K - $160K/yr

  • Medical

  • Life

  • Retirement

  • PTO

Senior DevOps Engineer Location: Louisville, KY (Hybrid) About El Toro At El Toro, everything we do ... Python, Shell, Go, or similar * Security-First Mindset: Familiarity with advanced security ...

$184 - $357/hr

NVIDIA is seeking a Senior MLOps Engineer to join our Autonomous Driving organization in Santa ... Work across Python, C++, distributed systems, cloud infrastructure, CI/CD, and data platforms.

New

$160 - $195/hr

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

  • PTO

The Role We are looking for a Senior Applied AI Engineer to help design, build, and scale the ... Strong Python development experience * Experience designing and building backend services or ...

New

$176 - $276/hr

## Senior DevOps Engineer, Platform EngineeringApplylocations: US, CA, Santa Claratime type: Full ... Advanced skills in Python for scripting, tooling, and automation.* Deep expertise with Kubernetes ...

New

Senior DevOps Engineer

Louisville, KY · On-site

$120 - $180/hr

  • Medical

  • Life

  • Retirement

  • PTO

Senior DevOps Engineer Location: Louisville, KY (Hybrid) At El Toro, everything we do starts with ... Python, Shell, Go, or similar. * Security-First Mindset: Familiarity with advanced security ...

$110 - $130/hr

  • Medical

  • PTO

We are seeking a highly skilled Senior Java Developer with proven experience using Cursor AI to ... Utilize programming languages like Java, Python or other object-oriented languages, SQL, and NoSQL ...

New

Senior Developer

Louisville, KY

$52.25 - $69.25/hr

... Java, Python, Azure an MQ Series etc. Excitement, curiosity, and passion for shaping the future ... DevOps, Multi-Cloud technologies, IoT, Intelligent Automation, RPA, Test automation, artificial ...

$155 - $175/hr

... Sr Manager, Software Engineering FullTime Senior Management Dallas, TX, US 30+ days ago ... The ideal candidateis a hands-on architect and engineer, proficient in Angular, React, Java, Python ...

$103 - $191/hr

  • Medical

  • Retirement

  • PTO

## Senior IT Data ScientistApplylocations: Remote-MO: Remote-NY: Remote-VA: Remote-PA: Remote ... Knowledge of Python (Programming Language); R (Programming Language)* Experience with Continuous ...

New

$117 - $176/hr

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

  • PTO

## Senior Engineer, MDRApplylocations: Remote - USAtime type: Full timeposted on: Posted Todayjob ... Programming experience in Bash, Python, PowerShell, or Go.* Experience in deploying software and ...

$145 - $175/hr

  • Medical

  • Dental

  • Vision

  • Retirement

  • PTO

Strong proficiency in Python, with experience building services, APIs, and integrations ... DevOps, and clinical stakeholders Preferred: * Experience in healthcare or a related regulated ...

New

$195 - $215/hr

  • Medical

  • Life

Enterprise - Senior Test Engineer - Linux, Python, GitLab * Columbia, MD Erias Ventures was founded ... Familiarity with SQL and tools such as SQL Developer, including writing queries and using them ...

New

$121 - $202/hr

  • Medical

  • Dental

  • Vision

  • Retirement

  • PTO

As a Senior Associate, you will focus on building meaningful client connections and learning how to ... Utilizing programming languages such as Python and Java to build and deploy AI models * Integrating ...

New

$145 - $175/hr

  • Medical

  • Dental

  • Vision

  • Retirement

  • PTO

# Remote Senior Software Engineer (AI-Native) Job at B-StockUSAan hour agoFull TimeUSA$25000 - $40000 ... Python* Rust* Ruby* JavaSkills required for this role include JavaScript, TypeScript, React, and ...

$170 - $265/hr

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

  • PTO

... SR. SECURITY ENGINEER SpaceX is looking for a Sr. Security Engineer to join the Security ... the Python programming language, GO, C#, or Rust. * 5+ years of experience designing and ...

New

$120 - $150/hr

In this senior-level role, you will leverage your background in Full-Stack Engineering not to write ... Python/Bash) and automation tools. Infrastructure & Reliability * Infrastructure as Code (IaC)

New

$184 - $287/hr

Join the Developer Tools team as a senior software engineer to work on profiling tools within the ... Ability to work across the full stack, including the server side code in Python and frontend code ...

New

$184 - $357/hr

... enhance developer productivity, accelerate feedback loops, and improve release reliability ... Hands-on experience on Python/Java/Go with extensive python scripting experience.* Experience in ...

$127 - $190/hr

## Sr Software Engineer, AI Tools - QuantizerRaleigh, North Carolina, United States of AmericaApply ... Python and/or C/C++* Strong software development skills (e.g. data structure and algorithm design ...

New

Showing results 41-60

Senior Python Developer information

See Kentucky salary details

$47.8K

$123.3K

$169.4K

How much do senior python developer jobs pay per year?

As of Aug 19, 2026, the average yearly pay for senior python developer in Kentucky is $123,310.00, according to ZipRecruiter salary data. Most workers in this role earn between $105,500.00 and $142,000.00 per year, depending on experience, location, and employer.

What are the main responsibilities of a senior Python developer?

A Senior Python Developer is responsible for designing, developing, and maintaining complex software applications using the Python programming language. They lead the technical aspects of projects, mentor junior developers, and ensure code quality through code reviews and best practices. Additionally, they collaborate with cross-functional teams to gather requirements, solve technical challenges, and deploy scalable and efficient solutions. Senior Python Developers are also expected to stay updated with the latest trends and advancements in Python and related technologies.

What are the key skills and qualifications needed to thrive as a senior Python developer?

To thrive as a Senior Python Developer, you need advanced proficiency in Python programming, experience with software architecture, and a solid understanding of algorithms and data structures, usually backed by a degree in computer science or related fields. Familiarity with frameworks like Django or Flask, version control systems such as Git, and containerization tools like Docker are typically required, alongside knowledge of modern CI/CD pipelines. Strong problem-solving abilities, effective communication, and leadership skills help you collaborate with teams and mentor junior developers. Mastery of these skills ensures the delivery of scalable, maintainable software solutions and the ability to drive technical excellence within development teams.

What are some common challenges faced by senior Python developers when leading a development team?

Senior Python Developers often encounter challenges such as balancing hands-on coding with mentoring junior team members and ensuring code quality across the team. They are also responsible for making architectural decisions, which requires staying updated on best practices and emerging Python frameworks. Additionally, coordinating collaboration between cross-functional teams (like DevOps, QA, and front-end developers) can be complex, especially in agile environments where requirements may shift rapidly. Overcoming these challenges helps foster a productive and innovative team culture.

What is the difference between Senior Python Developer vs Python Developer?

AspectSenior Python DeveloperPython Developer
Required ExperienceTypically 5+ years, with leadership and complex project experienceUsually 1-3 years, focusing on core Python skills
ResponsibilitiesDesigning architecture, mentoring, handling complex systemsWriting code, debugging, implementing features
CertificationsOptional but beneficial (e.g., Python certifications, cloud certs)Often not required
Work EnvironmentCollaborative teams, project planning, code reviewsDevelopment-focused, task-oriented

The main difference between a Senior Python Developer and a Python Developer lies in experience, responsibilities, and leadership. Senior developers handle complex projects, mentor others, and often participate in architecture decisions, while Python Developers focus on coding and feature implementation. Both roles are essential in tech companies, but the senior role requires more experience and broader skills.

Are senior Python developers still in demand?

Senior Python developers remain in high demand due to the language's versatility in web development, data analysis, machine learning, and automation. Companies seek experienced developers with skills in frameworks like Django or Flask, and proficiency in cloud platforms and APIs enhances job prospects.

How much does a senior Python developer make?

A senior Python developer typically earns between $100,000 and $150,000 annually, depending on experience, location, and industry. They often possess strong skills in frameworks like Django or Flask and may hold certifications or advanced degrees that influence salary levels.

What does a senior Python developer do?

A senior Python developer designs, develops, and maintains complex software applications using Python. They often lead projects, review code, optimize performance, and collaborate with cross-functional teams, requiring strong problem-solving skills and knowledge of frameworks like Django or Flask. Additionally, they may mentor junior developers and ensure code quality through testing and best practices.

What are the most commonly searched types of Python Developer jobs in Kentucky?

The most popular types of Python Developer jobs in Kentucky are:

What are popular job titles related to Senior Python Developer jobs in Kentucky?

For Senior Python Developer jobs in Kentucky, the most frequently searched job titles are:

What job categories do people searching Senior Python Developer jobs in Kentucky look for?

The top searched job categories for Senior Python Developer jobs in Kentucky are:

What cities in Kentucky are hiring for Senior Python Developer jobs?

Cities in Kentucky with the most Senior Python Developer job openings:

What are popular job titles related to Senior Python Developer jobs in KY?

For Senior Python Developer jobs in KY, the most frequently searched job titles are:

Infographic showing various Senior Python Developer job openings in Kentucky as of August 2026, with employment types broken down into 1% Internship, 83% Full Time, 10% Part Time, and 6% Contract. Highlights an 79% Physical, 6% Hybrid, and 15% Remote job distribution, with an average salary of $123,310 per year, or $59.3 per hour.

Associate Director, Senior AI Engineer

Otsuka Pharmaceutical Co., Ltd

Princeton, KY • On-site

$169.22 - $253/hr

Other

Medical, Dental, Vision, Life, Retirement, PTO

Posted 7 days ago


Job description

We are seeking a hands on Sr. AI Platform Engineer (Associate Director) to collaborate and drive platform aligned AI outcomes across the enterprise. The role provides engineering leadership and AI solution architecture oversight for platform and framework deliverables - reference patterns and guardrails, CI/CD & IaC blueprints, governance by design controls, observability, and cost/performance posture - delivered on approved platforms (Dataiku, Azure AI, AWS Bedrock/AgentCore, Snowflake Cortex). Operating in a regulated pharmaceutical environment, you will lead small delivery teams and collaborate with Data Science, Cloud/Infrastructure, and IT to guide use cases onto secure, reliable, compliant production pathways, while building reusable components and agentic enablement patterns adopted across domains. Design and Engineer reusable Agentic AI components and multi‑agent workflows for planning, reasoning, memory, and tool orchestration using LangChain, LangGraph, AutoGen, and Semantic Kernel. Apply emerging AI interaction standards including Model Context Protocol (MCP) and A2A (Agent‑to‑Agent) communication to support scalable multi‑agent systems. Lead small platform/ partner teams to deliver framework components: CI/CD blueprints, IaC modules, prompt/model versioning, evaluation harnesses, policy‑as‑code, observability dashboards (telemetry/drift/safety), and incident runbooks. Help and drive enablement of the Agentic AI C4E by creating practitioner knowledge articles, supporting and leading office hours, and engaging on project scoping, architecture reviews, and governance alignment. Contribute and operationalize enterprise AI reference architectures, standards, and guardrails to align teams on consistent patterns and quality. Implement evaluation frameworks for LLMs, prompts, safety/guardrails, hallucination risk, and performance metrics; de‑emphasize RAG where not required. Contribute to enhancing internal AI frameworks, orchestration templates, and reusable components to improve scalability and delivery consistency. Collaborate with Platform Engineering to align deployments with enterprise CI/CD, observability, governance, and operational standards; advance reliability for AI workloads (SLOs, telemetry, incident prevention) with SRE/SecOps. Ensure solutions follow Responsible AI practices, security requirements, privacy‑by‑design, and pharma regulatory controls (GxP, 21 CFR Part 11); embed security‑by‑design and policy enforcement with documentation and traceability. Influence technical priorities, sequencing, and trade‑offs across partner teams; provide inputs to vendor selection and adoption decisions where relevant. Guide solution teams onto approved platform pathways (Dataiku automation, Azure/AWS AI services, Snowflake Cortex), ensuring scalability, reliability (SLOs), security, and governed delivery in a regulated setting. Influence priorities and sequencing, unblock delivery risks, and communicate progress, risks, and value to senior stakeholders.

Qualifications

10–12+ years of hands‑on experience in AI/ML Platform Engineering, LLMOps/MLOps, DevOps with a proven track record of building and deploying production‑grade AI systems. Depth with cloud AI platform services on Azure (OpenAI, Azure AI/ML, Cognitive Search) and AWS (Bedrock, AgentCore, Comprehend, SageMaker), with sound build‑vs‑buy judgment. Strong Python engineering skills and proficiency with FastAPI or Flask for building AI‑powered services. Hands‑on with Dataiku for workflow orchestration, automation scenarios, model integration, or plugin‑based extensions. Deep familiarity with Agentic AI frameworks - LangChain, LangGraph, AutoGen, Semantic Kernel - with demonstrated experience building multi‑agent workflows, autonomous task orchestration, and tool‑enabled agent systems. (RAG familiarity is valued but not the primary emphasis.) Experience with prompt engineering and iterative prompt refinement for internal LLM use cases. Working knowledge of containerization (Docker), CI/CD tooling, and vector database integrations (e.g., OpenSearch, Pinecone). Strong collaboration skills and the ability to work closely with data scientists, engineers, security/compliance partners, and business stakeholders in a regulated environment. Effective communication, technical storytelling, and problem‑solving skills; able to influence technical direction across teams. Self‑motivated, hands‑on, and results‑oriented, with continuous learning in GenAI, Agentic AI, and modern orchestration patterns. Educational Qualifications Bachelor’s degree in Computer Science, Information Technology, Engineering, or related field (or equivalent experience).

Preferred Certifications (nice to have)

Cloud/GenAI: AWS or Azure AI / AWS or Azure Developer / AWS Solutions Architect; AWS Bedrock or Generative AI, Machine Learning Specialty. Agentic/AI Tooling: LangChain / Semantic Kernel badges or equivalent micro‑credentials.

Competencies
  • Accountability for Results - Stay focused on key strategic objectives, be accountable for high standards of performance, and take an active role in leading change.
  • Strategic Thinking & Problem Solving - Make decisions considering the long‑term impact to customers, patients, employees, and the business.
  • Patient & Customer Centricity - Maintain an ongoing focus on the needs of our customers and/or key stakeholders.
  • Impactful Communication - Communicate with logic, clarity, and respect.
  • Influence at all levels to achieve the best results for Otsuka.
  • Respectful Collaboration - Seek and value others’ perspectives and strive for diverse partnerships to enhance work toward common goals.
  • Empowered Development - Play an active role in professional development as a business imperative.

Minimum $169,222.00 - Maximum $253,000.00, plus incentive opportunity: The range shown represents a typical pay range or starting pay for individuals who are hired in the role to perform in the United States. Other elements may be used to determine actual pay such as the candidate’s job experience, specific skills, and comparison to internal incumbents currently in role. Typically, actual pay will be positioned within the established range, rather than at its minimum or maximum. This information is provided to applicants in accordance with states and local laws.

Application Deadline: This will be posted for a minimum of 5 business days.

Company benefits: Comprehensive medical, dental, vision, prescription drug coverage, company provided basic life, accidental death & dismemberment, short-term and long-term disability insurance, tuition reimbursement, student loan assistance, a generous 401(k) match, flexible time off, paid holidays, and paid leave programs as well as other company provided benefits.

We invite you to explore our open positions for an opportunity to join our 2,200 colleagues in the U.S. whose passion for our mission and pride in our company have earned us certification as a Great Place to Work by the Great Place to Work Institute.

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