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Senior Computer Science Bioinformatics Jobs in Princeton, NJ

Formation Bio

Senior Data Scientist

New York, NY · Hybrid

$177K - $232K/yr

Lead and execute complex data science projects that directly advance our drug development portfolio ... Extensive experience in multi-modal bioinformatics analysis Preferred Qualifications * Proven ...

Flex

Senior Staff Decision Science (Risk)

New York, NY · On-site

About the role We are seeking an experienced Senior Staff Decision Scientist to join our Risk and ... A graduate degree in Statistics, Mathematics, Computer Science, or a related quantitative field.

R3TEK

Senior Software Engineer

Hillsborough, NJ · On-site

$124K - $164K/yr

R3 Technology Inc. seeks Senior Software Engineer for it Hillsborough NJ office. Responsible for ... Must have Master's in Computer Science, Engineering, Information Systems or a related degree & 3 ...

R3tek

Senior Software Engineer

Hillsborough, NJ · On-site

$124K - $164K/yr

R3 Technology Inc. seeks Senior Software Engineer for it Hillsborough NJ office. Responsible for ... Must have Master's in Computer Science, Engineering, Information Systems or a related degree & 3 ...

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Senior Computer Science Bioinformatics information

See Princeton, NJ salary details

$88.6K

$107.2K

$125.3K

How much do senior computer science bioinformatics jobs pay per year?

As of Aug 20, 2026, the average yearly pay for senior computer science bioinformatics in Princeton, NJ is $107,207.00, according to ZipRecruiter salary data. Most workers in this role earn between $99,100.00 and $115,300.00 per year, depending on experience, location, and employer.

What does a senior computer science bioinformatics professional do?

A Senior Computer Science Bioinformatics professional applies advanced computational methods and software development techniques to analyze biological data, such as DNA, RNA, and protein sequences. They design and implement algorithms, manage large datasets, and collaborate with biologists to interpret results for research or clinical purposes. Their work often supports discoveries in genomics, drug development, and personalized medicine. In addition to technical expertise, they may lead teams, mentor junior staff, and oversee complex projects.

What are the key skills and qualifications needed to thrive as a senior computer science bioinformatics professional?

To thrive as a Senior Computer Science Bioinformatics professional, you need advanced knowledge in computational biology, programming (such as Python, R, or Java), and a strong background in molecular biology or genomics, often supported by a graduate degree (MSc or PhD). Proficiency with bioinformatics tools (like BLAST, GATK, or Bioconductor), high-performance computing environments, and version control systems (e.g., Git) is essential. Strong problem-solving abilities, analytical thinking, and effective collaboration skills set top performers apart in this field. These competencies are crucial for managing complex biological datasets, developing innovative algorithms, and driving impactful research in interdisciplinary teams.

How does a senior computer science bioinformatics professional typically collaborate with multidisciplinary teams?

Senior Computer Science Bioinformatics professionals often work closely with biologists, clinicians, statisticians, and software engineers to analyze complex biological datasets. They are responsible for translating biological questions into computational problems, developing algorithms or pipelines, and ensuring that results are accurate and actionable. Effective communication and collaboration are essential, as they must bridge the gap between technical and scientific teams, lead project discussions, and sometimes mentor junior team members. This collaborative environment fosters innovation and helps drive research projects or clinical applications forward.
Senior Computer Science Bioinformatics jobs near you

Senior Software Engineer & Project Lead, Biology

Simons Foundation

New York, NY • On-site

$190K - $235K/yr

Full-time

Re-posted 14 days ago

Job description

POSITION SUMMARY
The Center for Computational Biology is seeking an experienced software engineer to be the Project Lead for HumanBase (hb.flatironinstitute.org), a dynamic and interactive web-based platform that supports thousands of biomedical researchers in exploring the molecular mechanisms of human disease. This position is ideal for an experienced engineering leader with bioinformatics experience who thrives on solving complex problems at the intersection of large-scale data, advanced analytics, and scientific discovery. This is a high-impact role that directly advances the study of human genomics and disease.
The successful candidate will lead technical direction and execution, guide other software engineers, and collaborate closely with researchers at the Center for Computational Biology to translate cutting-edge computational biology into robust software tools. The Project Lead will be a hands-on engineering leader with experience in biological data and -omics technology, as well as a complementary skillset that includes both writing high-quality code and managing a small team of software engineers. Success in this role depends on the ability to translate biological questions into computational solutions, collaborate closely with internal scientific stakeholders, and drive technically rigorous projects that advance our understanding of human biology.
ESSENTIAL FUNCTIONS/RESPONSIBILITIES
  • Serve as technical lead for HumanBase, guiding the design, architecture, and implementation of new features and major infrastructure upgrades
  • Lead and mentor a team of full stack software engineers, ensuring high-quality code, efficient workflows, and continuous professional development
  • Plan, develop, and optimize scalable genomics data processing pipelines
  • Integrate machine learning methods into production pipelines to analyze heterogeneous biological datasets
  • Establish and enforce software engineering best practices, including coding standards, version control, documentation, testing, and deployment workflows
  • Collaborate cross-functionally with computational biologists, data scientists, and external partners to align engineering efforts with scientific goals
  • Stay current with emerging technologies in cloud infrastructure, bioinformatics, and scientific computing and assess their relevance for HumanBase
  • Perform additional duties or projects as assigned

MINIMUM QUALIFICATIONS
Education
  • B.S. in Computer Science, Software Engineering, or a related technical field

Experience
  • At least 10 years of professional software experience in software engineering, including leading teams and direct involvement in the planning, design, and development of software
  • Experience collaborating daily with other key team members of different technical and scientific backgrounds
  • Proficiency in full stack software development
  • Extensive experience in Python, including developing data pipelines and software libraries
  • Demonstrated experience with the full software development lifecycle (SDLC), including testing, CI/CD, version control, and deployment
  • Experience building and maintaining web-based interfaces and applications
  • Background in computational biology, bioinformatics, or a related field, with experience developing software in support of biological research
  • Experience working with large, heterogeneous biological datasets-ideally in genomics or biomedical contexts

Related Skills & Other Requirements
  • Effective technical leadership and mentorship abilities
  • Excellent communication skills, especially when working across disciplinary boundaries
  • Deep curiosity about science and a passion for building tools that empower scientific discovery
  • Strong sense of ownership and drive for continuous improvement

COMPENSATION
  • The range for full-time annual compensation for this position is $190,000-$235,000 based on experience.
  • In addition to competitive salaries, the Simons Foundation provides employees with an outstanding benefits package.

REQUIRED APPLICATION MATERIALS
  • Please submit a résumé and cover letter stating your interest in the position.

Our Commitment to Expanding Pathways to Science & Opportunities for All:
Many of the greatest ideas and discoveries come from a diverse mix of minds, backgrounds, and experiences. The Simons Foundation is committed to advancing basic science and mathematics to benefit humankind and expand our collective understanding of our world. As part of our mission, we support partners, programs, and initiatives that seek to broaden the scientific community and open pathways to science and mathematics careers.
The Simons Foundation provides equal opportunities to all applicants without regard to race, religion, color, age, sex, pregnancy, national origin, sexual orientation, gender identity, genetic disposition, neurodiversity, disability, veteran status, or any other protected category under federal, state, and local law.

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