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Senior Backend Python Jobs in New York, NY (NOW HIRING)

Doctronic Inc

Senior Backend Engineer

New York, NY · On-site

$85K - $240K/yr

  • Medical

Senior Backend Engineer Doctronic | New York City ONSITE (Hybrid) | Reports to CEO The Mission Let ... Scalable APIs using Python, FastAPI, AWS handling millions of monthly requests * RESTful API ...

NxT Level

Senior Backend Engineer

Manhattan, NY · On-site

Senior Backend Engineer WHY THIS ROLE EXISTS Our client is building AI technology to make health ... Design and maintain high performance APIs using Python and cloud services to handle millions of ...

DualEntry

Senior Backend Engineer (NYC)

Manhattan, NY · On-site

As a Senior Backend Engineer, you will architect and build core backend systems, manage complex ... Responsibilities : • Design and build core backend systems (Python preferred) • Build APIs ...

NxT Level

Senior Backend Engineer

Manhattan, NY · On-site

Senior Backend Engineer WHY THIS ROLE EXISTS Our client is building AI technology to make health ... Design and maintain high performance APIs using Python and cloud services to handle millions of ...

Qodo (formerly Codium)

Senior Software Engineer

Manhattan, NY · On-site

$120 - $160/hr

  • Medical

  • Dental

  • Vision

  • Retirement

  • PTO

We're seeking a Senior Backend Engineer to join our Shift-left Solutions team. This team is focused ... Backend**: Python, FastAPI* **Data Stores**: PostgreSQL, Redis* **AI/ML**: OpenAI and other LLM ...

Hapiko

Senior+ Backend Engineer

Brooklyn, NY · On-site

They are seeking a Senior Backend Engineer to own and evolve the real-time infrastructure behind ... Required : • 5+ years building and shipping backend systems in Python • Deep experience with ...

Bevel

Senior Backend Engineer

New York, NY · On-site

$180K - $215K/yr

  • Medical

  • Dental

  • Vision

  • Retirement

  • PTO

We're looking for incredible Senior Backend Engineers to help us build an ambitious roadmap. You'll ... Expertise coding in Typescript or Python * Strong intuition for algorithms and working with data

Beli

Senior Backend Infrastructure Engineer

New York, NY · On-site

$200K - $260K/yr

Senior Backend Infrastructure Engineer (GCP) By changing the way people explore restaurants, Beli ... Strong experience with Python and backend frameworks such as Django * Deep knowledge of CI/CD ...

Slang AI

Sr Backend Engineer

New York, NY · On-site

$185K - $215K/yr

Our backend is written in Kotlin, but prior Kotlin experience is not required; strong fundamentals ... Strong proficiency in at least one object-oriented language (e.g., Java, Kotlin, C#, Python ...

Giga AI Inc

Senior Backend Engineer

New York, NY · On-site

$200K - $350K/yr

  • Medical

  • Dental

  • Vision

  • Retirement

... a senior engineer, you'll be expected to make sound technical decisions, ship reliably, and help ... Backend: Python (Django/FastAPI), TypeScript (Node.js) * Infrastructure: AWS, Modal, Kubernetes ...

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Senior Backend Python information

See New York, NY salary details

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How much do senior backend python jobs pay per year?

As of Aug 13, 2026, the average yearly pay for senior backend python in New York, NY is $162,172.00, according to ZipRecruiter salary data. Most workers in this role earn between $159,200.00 and $183,200.00 per year, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive as a senior backend Python developer?

To thrive as a Senior Backend Python Developer, you need expertise in Python programming, strong knowledge of backend frameworks (such as Django or Flask), and experience with database management, often backed by a degree in computer science or equivalent experience. Familiarity with version control systems like Git, containerization tools like Docker, cloud platforms (e.g., AWS), and possibly certifications in cloud or Python technologies are common requirements. Outstanding problem-solving skills, effective communication, and the ability to mentor junior developers help set top performers apart. These competencies ensure the development of robust, scalable, and maintainable backend systems that support business objectives.

What is the difference between Senior Backend Python vs Backend Developer?

AspectSenior Backend PythonBackend Developer
Required CredentialsBachelor's in CS or related, 5+ years experience, Python expertiseBachelor's in CS or related, 2-4 years experience, Python knowledge
Work EnvironmentTech companies, startups, enterprise systemsTech firms, startups, software agencies
Employer & Industry UsageUsed across industries requiring scalable backend solutionsCommon in web development and software services
Search & Comparison IntentUnderstanding senior roles, responsibilities, salaryEntry to mid-level backend roles, skill requirements

Senior Backend Python professionals typically have more experience, advanced skills, and leadership responsibilities compared to Backend Developers. They often work on complex systems, mentor junior staff, and have a broader understanding of architecture. Backend Developers focus on building and maintaining backend services with less emphasis on leadership or strategic planning.

What are some common challenges senior backend Python developers face when working on large-scale systems?

Senior Backend Python developers working on large-scale systems often encounter challenges such as ensuring application scalability, maintaining code quality across distributed teams, and optimizing performance for high traffic. Balancing the integration of new features with legacy system constraints can also be demanding. Effective communication and collaboration with frontend teams, DevOps, and product managers are crucial for delivering reliable and maintainable backend solutions.

What does a senior backend Python developer do?

A Senior Backend Python Developer designs, builds, and maintains the server-side logic of web applications using Python. They are responsible for creating robust APIs, optimizing databases, ensuring application security, and integrating third-party services. In addition, they often mentor junior developers, contribute to architectural decisions, and collaborate closely with frontend and DevOps teams. Their work ensures that applications are scalable, reliable, and efficient. Senior developers typically have several years of experience and deep knowledge of Python frameworks like Django or Flask.

What are the most commonly searched types of Backend Python jobs in New York, NY?

The most popular types of Backend Python jobs in New York, NY are:

What cities near New York, NY are hiring for Senior Backend Python jobs?

Cities near New York, NY with the most Senior Backend Python job openings:

Senior Backend Python jobs near you

Senior Backend Engineer

Doctronic Inc

New York, NY • On-site

$85K - $240K/yr

Full-time

Medical

Re-posted 23 days ago

Job description

Senior Backend Engineer
Doctronic | New York City ONSITE (Hybrid) | Reports to CEO
The Mission
Let's make healthcare free and accessible to everyone through AI. We need backend infrastructure that can scale our AI doctor platform to billions of consultations while maintaining medical safety and HIPAA compliance.
What You'll Build
Healthcare API Infrastructure
  • Scalable APIs using Python, FastAPI, AWS handling millions of monthly requests
  • RESTful API development supporting our AI healthcare tools
  • Real-time data processing for sensitive patient information (HIPAA-compliant)
  • Internal API architecture for web platform and AI coordination

Integration & Data Systems
  • Secure health record exchange with EHR systems, QHINs, healthcare networks
  • Third-party integrations: telehealth providers, analytics platforms, healthcare APIs
  • Large-scale sensitive data processing with encryption and compliance safeguards
  • Partner API integrations across dozens of diverse healthcare systems

Scale & Reliability
  • Database optimization for high-volume healthcare data with complex queries
  • Redis for secure caching and session management in healthcare environments
  • Error handling, failover systems, disaster recovery for mission-critical services
  • Performance optimization for rapid user growth

AI System Integration
  • Backend coordination for AI tools and decision-making workflows
  • Python-based deterministic systems working alongside AI agents for clinical accuracy
  • APIs supporting model inference, data preprocessing, result processing
  • Infrastructure for AI safety: validation layers and human escalation protocols

You'll also work on healthcare compliance automation, advanced monitoring, multi-region deployment, and backend foundation for next-generation AI healthcare features.
How We Work
  • Engineering-first org: no project managers, just senior engineers
  • Flat structure with direct CEO reporting and high autonomy
  • Own features end-to-end from minimal specs to production
  • AI coding tools encouraged
  • Ship fast with good judgment; daily standups for alignment, not micromanagement

Required Qualifications
Education & Background
  • CS degree OR equivalent demonstrated expertise
  • Engineering, Math, or related technical degrees welcomed with strong programming foundation
  • Preference for graduates from top programs at top universities
  • Preference for founders, founding engineers, or extensive startup experience
  • Independent problem solver who collaborates well cross-functionally

Technical Expertise
  • 6+ years backend engineering with Python and API development
  • FastAPI, Flask, or similar Python web frameworks
  • Cloud services experience
  • RESTful APIs, high-volume traffic handling
  • Relational databases (PostgreSQL, MySQL) and optimization
  • Redis, caching strategies, distributed systems design

System Design & Integration
  • Third-party API integrations and webhook management
  • Microservices architecture and distributed system patterns
  • Security best practices for sensitive data and API design
  • CI/CD pipelines, containerization (Docker), deployment automation
  • Monitoring, logging, observability tools

Preferred Qualifications
  • Systems for healthcare, fintech, or regulated industries
  • Healthcare data standards (HL7, FHIR) and HIPAA compliance
  • High-scale data processing and real-time systems
  • AI/ML systems and model serving infrastructure
  • Message queues, event-driven architectures, async processing
  • Healthcare workflows, EHR systems, telehealth platforms
  • Seed/Series A experience in healthcare or technology
  • Advanced degree in CS, Engineering, or related field

What We Offer
  • Competitive salary plus significant equity
  • Build infrastructure transforming healthcare accessibility for millions
  • Direct CEO reporting with significant autonomy
  • Access to leading technologies and healthcare experts
  • Benefits reimbursement

Funding & Momentum
  • Union Square Ventures led our seed (Feb 2025)
  • Lightspeed Venture Partners preempted our Series A six months later (Aug 2025)
  • Abstract preempted our Series B five months later (Jan 2026)
  • Significant equity stake in fast-moving, well-backed company

About Doctronic
Doctronic is the #1 AI Doctor, revolutionizing direct-to-patient healthcare through our proprietary AI system. Doctronic is the first AI legally authorized to practice medicine. We're processing millions of consultations monthly with 99%+ treatment plan accuracy validated by board-certified clinicians. Our platform (doctronic.ai) provides free, anonymous, HIPAA-compliant AI consultations alongside affordable human physician visits ($40) available 24/7 across all 50 states via instant video, scheduled video, or async text.

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