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Senior Backend Python Jobs in Columbus, OH (NOW HIRING)

giftHEALTH Inc

Staff Software Engineer

Columbus, OH · On-site

$164K - $205K/yr

Advanced proficiency in at least one backend language (e.g., Ruby, Elixir, Python, Java, Go, or ... Regular meetings with internal Engineering Managers, Product Managers, Designers, Senior and Staff ...

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Senior Backend Python information

See Columbus, OH salary details

$15.5K

$143.2K

$184.5K

How much do senior backend python jobs pay per year?

As of Sep 10, 2026, the average yearly pay for senior backend python in Columbus, OH is $143,178.00, according to ZipRecruiter salary data. Most workers in this role earn between $140,500.00 and $161,800.00 per year, depending on experience, location, and employer.

What does a senior backend Python developer do?

A Senior Backend Python Developer designs, builds, and maintains the server-side logic of web applications using Python. They are responsible for creating robust APIs, optimizing databases, ensuring application security, and integrating third-party services. In addition, they often mentor junior developers, contribute to architectural decisions, and collaborate closely with frontend and DevOps teams. Their work ensures that applications are scalable, reliable, and efficient. Senior developers typically have several years of experience and deep knowledge of Python frameworks like Django or Flask.

What are the key skills and qualifications needed to thrive as a senior backend Python developer?

To thrive as a Senior Backend Python Developer, you need expertise in Python programming, strong knowledge of backend frameworks (such as Django or Flask), and experience with database management, often backed by a degree in computer science or equivalent experience. Familiarity with version control systems like Git, containerization tools like Docker, cloud platforms (e.g., AWS), and possibly certifications in cloud or Python technologies are common requirements. Outstanding problem-solving skills, effective communication, and the ability to mentor junior developers help set top performers apart. These competencies ensure the development of robust, scalable, and maintainable backend systems that support business objectives.

What are some common challenges senior backend Python developers face when working on large-scale systems?

Senior Backend Python developers working on large-scale systems often encounter challenges such as ensuring application scalability, maintaining code quality across distributed teams, and optimizing performance for high traffic. Balancing the integration of new features with legacy system constraints can also be demanding. Effective communication and collaboration with frontend teams, DevOps, and product managers are crucial for delivering reliable and maintainable backend solutions.

What is the difference between Senior Backend Python vs Backend Developer?

AspectSenior Backend PythonBackend Developer
Required CredentialsBachelor's in CS or related, 5+ years experience, Python expertiseBachelor's in CS or related, 2-4 years experience, Python knowledge
Work EnvironmentTech companies, startups, enterprise systemsTech firms, startups, software agencies
Employer & Industry UsageUsed across industries requiring scalable backend solutionsCommon in web development and software services
Search & Comparison IntentUnderstanding senior roles, responsibilities, salaryEntry to mid-level backend roles, skill requirements

Senior Backend Python professionals typically have more experience, advanced skills, and leadership responsibilities compared to Backend Developers. They often work on complex systems, mentor junior staff, and have a broader understanding of architecture. Backend Developers focus on building and maintaining backend services with less emphasis on leadership or strategic planning.

Senior Backend Python jobs near you

Senior AI Full stack Software Engineer

Columbus, OH • On-site, Remote

McKesson
Health Care and Social Assistance • 10K+ employees
Learn more about McKessonexternal

$131K - $218K/yr

Full-time

Re-posted 22 days ago

McKesson rating

8.0

Company rating: 8.0 out of 10

Based on 211 frontline employees who took The Breakroom Quiz

43rd of 86 rated pharmaceutical

Job description

McKesson is an impact-driven, Fortune 10 company that touches virtually every aspect of healthcare. We are known for delivering insights, products, and services that make quality care more accessible and affordable. Here, we focus on the health, happiness, and well-being of you and those we serve - we care.

What you do at McKesson matters. We foster a culture where you can grow, make an impact, and are empowered to bring new ideas. Together, we thrive as we shape the future of health for patients, our communities, and our people. If you want to be part of tomorrow's health today, we want to hear from you.

We are seeking a highly skilled and experienced Senior AI Full Stack Software Engineer to join our innovative team at CMM. This role involves designing, developing, and deploying end-to-end AI-powered solutions, from robust backend services to intuitive user interfaces, to enhance our healthcare and decision-making platforms.

Key Responsibilities

  • Lead AI-Driven Healthcare Solutions: Design and deploy AI applications that support decision-making, patient engagement, and operational efficiency.

  • Integrate AI into EHRs and Clinical Systems: Build scalable systems that incorporate LLMs, voice/image recognition, and document parsing into existing healthcare ITinfrastructure.

  • Develop and Optimize Data Pipelines: Ensure secure, HIPAA-compliant data pipelines for training and deploying AI models using structured and unstructured healthcare data (e.g., clinical notes, imaging, lab results).

  • Model Evaluation and Compliance: Apply rigorous evaluation metrics (e.g., sensitivity, specificity, AUC-ROC) and ensure models meet regulatory and ethical standards.

  • Mentor and Lead: Guide junior engineers and contribute to the strategic direction of AI initiatives within the organization.

  • Rapid AI prototyping and iteration with product representatives to vet multiple concepts

We are unable to provide sponsorship for this role presently or in the future.

Priority will be given to candidates who reside in the Columbus, OH and Atlanta, GA metropolitan area.

Minimum Qualifications

  • 10+ years of software engineering experience, with 4+ years in AI/ML development preferred.

  • B.S. degree in Computer Science or related engineering discipline, or equivalent experience

Critical Skills

  • 2+ years of experience building AI solutions in healthcare or lifesciences.

  • Deep understanding of healthcare data standards (e.g., HL7, FHIR) and compliance frameworks (e.g., HIPAA, GDPR).

  • Healthcare AI Expertise: Proven ability to build AI models for clinical NLP, medical imaging, patient risk stratification, and carepersonalization.

  • LLM & RAG Systems: Skilled in building retrieval-augmented generation systems using tools likePydantic, Semantic Kernel,LangChain,LlamaIndex, and vector databases.

  • Experienced in creating custom AI agents or spec-driven tools.

  • Experience writing skills for Claude, Copilot, Codex etc.

  • Prompt Engineering & Optimization: Advanced techniques for prompt tuning, caching, and benchmarking.

  • Full Stack Development: Proficiency in Python, Node.js, and modern web frameworks.

Preferred Skills

  • Cloud & DevOps: Experience with secure cloud environments (AWS/GCP/Azure), containerization (Docker, Kubernetes), and CI/CD pipelines.

  • AI Tooling: Familiarity with OpenAI, Hugging Face,PyDanticAI, TensorFlow,PyTorch, and healthcare-specific AI libraries.

  • Communication & Leadership: Ability to communicate complex AI concepts to clinical and executive stakeholders and lead cross-functional teams.

  • Experience mentoring and developing juniors in development an AI concepts/best practices.

We are proud to offer a competitive compensation package at McKesson as part of our Total Rewards. This is determined by several factors, including performance, experience and skills, equity, regular job market evaluations, and geographical markets. The pay range shown below is aligned with McKesson's pay philosophy, and pay will always be compliant with any applicable regulations. In addition to base pay, other compensation, such as an annual bonus or long-term incentive opportunities may be offered. For more information regarding benefits at McKesson, pleaseclick here.

Our Base Pay Range for this position

$131,000 - $218,300

McKesson has become aware of online recruiting-related scams in which individuals who are not affiliated with or authorized by McKesson are using McKesson's (or affiliated entities, like CoverMyMeds or RxCrossroads) name in fraudulent emails, job postings or social media messages. In light of these scams, please bear the following in mind:
McKesson Talent Advisors will never solicit money or credit card information in connection with a McKesson job application.


McKesson Talent Advisors do not communicate with candidates via online chatrooms or using email accounts such as Gmail or Hotmail. Note that McKesson does rely on a virtual assistant (Gia) for certain recruiting-related communications with candidates.

McKesson job postings are posted on our career site: careers.mckesson.com.

McKesson is an Equal Opportunity Employer

McKesson provides equal employment opportunities to applicants and employees, without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, age, genetic information, or any other legally protected category. For additional information on McKesson's full Equal Employment Opportunity policies, visit our Equal Employment Opportunity page.

McKesson is committed to being an Equal Employment Opportunity Employer and offers opportunities to all job seekers including job seekers with disabilities. If you need a reasonable accommodation to assist with your job search or application for employment, please contact us by sending an email to (United States) Disability_Accommodation@McKesson.com or (Canada) Accessibility@mckesson.ca. Resumes or CVs submitted to this email box will not be accepted.

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