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Senior Backend Developer Python Jobs in Indianapolis, IN

Senior Webflow Developer

Zionsville, IN

$52.75 - $69.75/hr

The Opportunity We are looking for a talented and detail-oriented Senior Webflow Developer to join ... back-end concepts or REST APIs. • Experience with conversion rate optimization (CRO) and A/B ...

Experience with object-oriented programming using languages such as Java, Python, or JavaScript ... Experience with at least one backend technology stack: Node.js, Python (Django or Flask), or Java ...

Senior Java Developer

Indianapolis, IN · On-site

$54.75 - $69.75/hr

Experienced Java developer with expertise in Spring Boot, REST API development, batch processing ... for backend development, and creation of scalable RESTful APIs. • The candidate must have ...

Senior Java Developer

Indianapolis, IN

$54.75 - $69.75/hr

Experienced Java developer with expertise in Spring Boot, REST API development, batch processing ... Resource is required with strong hands-on experience in Java, Spring Boot framework for backend ...

Software Developer

Indianapolis, IN · On-site

$70K - $80K/yr

... back-end development * Maintain and improve the DiscoverNewfields.org website and develop ... Server-side languages, especially NodeJS/Typescript and Python * Aptitude for analyzing diverse ...

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Senior Backend Developer Python information

See Indianapolis, IN salary details

$15.3K

$141.7K

$182.6K

How much do senior backend developer python jobs pay per year?

As of Jul 23, 2026, the average yearly pay for senior backend developer python in Indianapolis, IN is $141,691.00, according to ZipRecruiter salary data. Most workers in this role earn between $139,100.00 and $160,100.00 per year, depending on experience, location, and employer.

What does a Senior Backend Developer Python do?

A Senior Backend Developer Python designs, builds, and maintains the server-side logic and databases for web applications, primarily using the Python programming language. They are responsible for ensuring high performance, responsiveness, and security of applications, integrating with front-end elements, and working closely with other developers and stakeholders. Additionally, they often mentor junior developers, review code, and contribute to architectural decisions to ensure scalable and robust backend systems.

What is the difference between Senior Backend Developer Python vs Backend Developer Python?

AspectSenior Backend Developer PythonBackend Developer Python
Required Experience5+ years, leadership skills1-3 years, foundational skills
CertificationsRelevant certifications (e.g., AWS, Python)Optional, entry-level certifications
Work EnvironmentDesigning architecture, mentoringImplementing features, coding
ResponsibilitiesSystem design, team coordinationCode development, bug fixing

The main difference between a Senior Backend Developer Python and a Backend Developer Python lies in experience, responsibilities, and leadership. Senior developers typically lead projects and mentor others, while backend developers focus on coding and feature implementation. Both roles require strong Python skills and relevant certifications, but senior roles demand more experience and strategic involvement.

What are the key skills and qualifications needed to thrive as a Senior Backend Developer Python, and why are they important?

To thrive as a Senior Backend Developer Python, you need deep expertise in Python programming, software architecture, and experience with databases and API development, usually supported by a computer science degree and several years of professional coding experience. Familiarity with frameworks like Django or Flask, cloud platforms (e.g., AWS, Azure), and version control systems such as Git is typically expected, along with knowledge of containerization tools like Docker. Strong problem-solving skills, collaboration, and clear communication set top performers apart in this role. These skills ensure the development of robust, scalable backend systems that meet business needs and support seamless integration with other technologies.

What are some common challenges faced by Senior Backend Developers working with Python, and how can they be addressed?

Senior Backend Developers working with Python often encounter challenges such as ensuring high performance and scalability of applications, especially when dealing with large volumes of data or high user traffic. Managing dependencies and maintaining clean, modular codebases can also be demanding in complex projects. These challenges are typically addressed by leveraging advanced Python frameworks, implementing robust testing practices, and collaborating closely with DevOps and frontend teams to optimize system architecture and deployment pipelines. Continuous learning and staying updated with best practices in Python and backend development are also key to overcoming these obstacles.
What are popular job titles related to Senior Backend Developer Python jobs in Indianapolis, IN? For Senior Backend Developer Python jobs in Indianapolis, IN, the most frequently searched job titles are:
What job categories do people searching Senior Backend Developer Python jobs in Indianapolis, IN look for? The top searched job categories for Senior Backend Developer Python jobs in Indianapolis, IN are:
Infographic showing various Senior Backend Developer Python job openings in Indianapolis, IN as of July 2026, with employment types broken down into 90% Full Time, 5% Part Time, and 5% Contract. Highlights an 82% Physical, 4% Hybrid, and 14% Remote job distribution, with an average salary of $141,691 per year, or $68.1 per hour.

Senior Software Engineer Applied AI

Advanced Monitored Caregiving Inc.

Indianapolis, IN • Remote

$117K - $154K/yr

Full-time

Posted 8 days ago


Job description

Senior Software Engineer: Applied AI (Voice Agents & ML Systems)

AMC Health · Remote (US) · Full-time

The pitch

We build and operate production AI voice agents that hold real phone conversations in a regulated healthcare setting, plus the machine learning and LLM pipelines around them. This is one seat that spans four disciplines that rarely come together: real-time systems, LLM engineering, traditional machine learning, and serious cloud infrastructure, all in production, all with real consequences. If you are the kind of engineer who gets restless doing one thing, this role is the opposite problem.

What you'll work across

Real-time voice AI

  • Streaming, low-latency speech-to-speech systems built on modern LLMs
  • Telephony and real-time media (call control, live audio streaming)
  • Audio handling and the quirks of real human conversation (interruptions, timing, noise)
  • Concurrency on a latency-sensitive path, where p99 matters and a stall is something a caller hears

LLM engineering

  • Wrapping nondeterministic models in deterministic control so they behave reliably in production
  • Multi-model pipelines, prompt design, and cost/latency budgeting
  • Evaluation harnesses, including LLM-as-judge and automated agent-tests-agent approaches
  • Agentic tooling that gives AI systems safe, structured access to infrastructure

Traditional (non-LLM) machine learning

  • End-to-end ML pipelines: feature engineering, model training, and scheduled inference
  • Imbalanced, messy real-world data; calibration and explainability for non-technical consumers
  • Turning research notebooks into reproducible, auditable production pipelines

Cloud and infrastructure

  • Infrastructure as code across multiple environments (we run on AWS)
  • Managed compute, data, streaming, and orchestration services
  • Security engineering in a regulated setting: encryption, least-privilege access, strict data-handling discipline
  • Observability and telemetry-driven debugging, tracing a production issue from a metric anomaly to root cause

Plus occasional full-stack work on internal tools, and an engineering workflow that leans heavily on AI coding assistants, with human accountability for every change.

What you'll actually do

  • Ship and debug code on a live, real-time voice pipeline where latency and correctness are user-facing
  • Design control systems around LLMs: guardrails, budgets, watchdogs, safe fallbacks
  • Build and operate LLM evaluation and batch-analysis pipelines
  • Own traditional ML workflows from data to scheduled production inference
  • Trace production issues from a metric anomaly to root cause, including building the evidence when the cause is a vendor

Must-haves

  • 7+ years building and operating production backend systems, with strong general-purpose programming skills (we work primarily in Python)
  • Experience running distributed systems in the cloud; comfortable debugging from telemetry to root cause
  • Hands-on production experience with LLMs or generative AI (any provider or framework), plus the judgment to know when not to use a model
  • Working fluency across the traditional machine learning lifecycle (you productionize; you do not need to publish)
  • Disciplined in a regulated environment: small, reviewable changes and careful handling of sensitive data

Nice-to-haves

  • Real-time media or telephony experience
  • Front-end / full-stack ability
  • ML pipeline experience, vector search, or embeddings
  • Fluency with AI coding assistants (our workflows assume them, with human accountability for every change)

How we work

Smallest correct change wins. Every behavior change is validated against the live system. Evidence over opinion in debugging. Code review is rigorous. Safety and privacy gate everything.

Work authorization (no exceptions)

This role is open only to US citizens and lawful permanent residents (Green Card holders). We cannot consider candidates who require visa sponsorship now or in the future, and we are unable to make exceptions of any kind.

How to apply

Please submit both of the following:

  • Your LinkedIn profile URL
  • A phone number where we can reach you

A resume is welcome but optional; the two items above are required.