A typical shift for a SANE Nurse often involves being on call to respond to cases of sexual assault or abuse as they arise, which can occur during any hour, including nights and weekends. When not actively examining a patient, SANE Nurses may assist with training, community outreach, or documentation. The unpredictable nature of the workload means flexibility and readiness are important, and SANE Nurses frequently collaborate with law enforcement, advocacy groups, and emergency department staff. Depending on the healthcare facility, SANE Nurses may cover shifts solo or as part of a rotating team to provide 24/7 response coverage.