Associate Scientist, Process Development Location: Philadelphia, PA, On-Site Cabaletta Bio (Nasdaq: CABA) is a late-stage clinical biotechnology company focused on developing and launching curative ...
Associate Scientist, Process Development Location: Philadelphia, PA, On-Site Cabaletta Bio (Nasdaq: CABA) is a late-stage clinical biotechnology company focused on developing and launching curative ...
Associate Scientist, Process Development Location: Philadelphia, PA, On-Site Cabaletta Bio (Nasdaq: CABA) is a late-stage clinical biotechnology company focused on developing and launching curative ...
Associate Scientist, Process Development Location: Philadelphia, PA, On-Site Cabaletta Bio (Nasdaq: CABA) is a late-stage clinical biotechnology company focused on developing and launching curative ...
... drug development and research under general supervision. This role ensures the proper care and ... Conduct downstream analyses of ex vivo samples to support study objectives. * Assist in the ...
... drug development and research under general supervision. This role ensures the proper care and ... Conduct downstream analyses of ex vivo samples to support study objectives. * Assist in the ...
Research Associate
West Chester, PA · On-site
The Research Associate - Biomaterials R&D will work in a laboratory environment performing research and development activities on in collaboration with scientists and engineers in support of R&D or ...
Research Associate
West Chester, PA · On-site
The Research Associate - Biomaterials R&D will work in a laboratory environment performing research and development activities on in collaboration with scientists and engineers in support of R&D or ...
... ongoing drug development, as well as supporting the Computational Biology team by preparing ... Produce and titer lentivirus Assist with in vivo murine studies and downstream tissue processing ...
... ongoing drug development, as well as supporting the Computational Biology team by preparing ... Produce and titer lentivirus Assist with in vivo murine studies and downstream tissue processing ...
Research Associate
Philadelphia, PA · On-site
Development of report writing and presentation skills, which may include FDA IND submission material * Collaboration and mentorship from senior scientists What you will do at Integral Molecular:
Research Associate
Philadelphia, PA · On-site
Development of report writing and presentation skills, which may include FDA IND submission material * Collaboration and mentorship from senior scientists What you will do at Integral Molecular:
... process. Please do not apply here, apply internally through Workday. * CURRENT PENN STATE STUDENT ... Will assist in the development of research communication materials including plots, graphs, web ...
... process. Please do not apply here, apply internally through Workday. * CURRENT PENN STATE STUDENT ... Will assist in the development of research communication materials including plots, graphs, web ...
... process. Please do not apply here, apply internally through Workday. * CURRENT PENN STATE STUDENT ... Will assist in the development of research communication materials including plots, graphs, web ...
... process. Please do not apply here, apply internally through Workday. * CURRENT PENN STATE STUDENT ... Will assist in the development of research communication materials including plots, graphs, web ...
Research Associate
Philadelphia, PA · On-site
Development of report writing and presentation skills, which may include FDA IND submission material * Collaboration and mentorship from senior scientists What you will do at Integral Molecular:
Research Associate
Philadelphia, PA · On-site
Development of report writing and presentation skills, which may include FDA IND submission material * Collaboration and mentorship from senior scientists What you will do at Integral Molecular:
Research Associate
Philadelphia, PA · On-site
... Research Associate position in the Academic Support Staff. This appointment will be initially for ... Learn, apply, and contribute to the development of cutting-edge mass spectrometry-based methods for ...
Research Associate
Philadelphia, PA · On-site
... Research Associate position in the Academic Support Staff. This appointment will be initially for ... Learn, apply, and contribute to the development of cutting-edge mass spectrometry-based methods for ...
Rese-cel is currently being evaluated in the RESET (REstoring SElf-Tolerance) clinical development ... Actively contribute to process improvements and the implementation of new technologies. * Perform ...
Rese-cel is currently being evaluated in the RESET (REstoring SElf-Tolerance) clinical development ... Actively contribute to process improvements and the implementation of new technologies. * Perform ...
Rese-cel is currently being evaluated in the RESET (REstoring SElf-Tolerance) clinical development ... Actively contribute to process improvements and the implementation of new technologies. * Perform ...
Rese-cel is currently being evaluated in the RESET (REstoring SElf-Tolerance) clinical development ... Actively contribute to process improvements and the implementation of new technologies. * Perform ...
... and development of engineered T cell therapies with the potential to become deep and durable ... Actively contribute to process improvements and the implementation of new technologies. * Perform ...
... and development of engineered T cell therapies with the potential to become deep and durable ... Actively contribute to process improvements and the implementation of new technologies. * Perform ...
Research Associate
Philadelphia, PA · On-site
... several Research Associate positions in the Academic Support Staff. This appointment will be ... D. degree. Responsibilities may include developing and implementing signal processing pipelines ...
Research Associate
Philadelphia, PA · On-site
... several Research Associate positions in the Academic Support Staff. This appointment will be ... D. degree. Responsibilities may include developing and implementing signal processing pipelines ...
... drug development and research under general supervision. This role ensures the proper care and ... Conduct downstream analyses of ex vivo samples to support study objectives. Assist in the ...
... drug development and research under general supervision. This role ensures the proper care and ... Conduct downstream analyses of ex vivo samples to support study objectives. Assist in the ...
... drug development and research under general supervision. This role ensures the proper care and ... Conduct downstream analyses of ex vivo samples to support study objectives. * Assist in the ...
... drug development and research under general supervision. This role ensures the proper care and ... Conduct downstream analyses of ex vivo samples to support study objectives. * Assist in the ...
The Research Associate will contribute to various stages of the research process, including study ... design, data collection and analysis, literature reviews, and manuscript preparation and revisions.
The Research Associate will contribute to various stages of the research process, including study ... design, data collection and analysis, literature reviews, and manuscript preparation and revisions.
Research Associate
Philadelphia, PA · On-site
... Research Associate position in the Academic Support Staff. This appointment will be initially for ... sensory processing and sleep using Drosophila models of neurodevelopmental disorders.
Research Associate
Philadelphia, PA · On-site
... Research Associate position in the Academic Support Staff. This appointment will be initially for ... sensory processing and sleep using Drosophila models of neurodevelopmental disorders.
Research Associate
Kennett Square, PA · On-site
$80K - $95K/yr
When you work at Chatham, we empower you - offering professional development opportunities to help ... Own and coordinate the production process for recurring Research Team deliverables Manage the ...
Research Associate
Kennett Square, PA · On-site
$80K - $95K/yr
When you work at Chatham, we empower you - offering professional development opportunities to help ... Own and coordinate the production process for recurring Research Team deliverables Manage the ...
Research Associate
Kennett Square, PA · On-site
$80K - $95K/yr
When you work at Chatham, we empower you - offering professional development opportunities to help ... Responsibilities : • Own and coordinate the production process for recurring Research Team ...
Research Associate
Kennett Square, PA · On-site
$80K - $95K/yr
When you work at Chatham, we empower you - offering professional development opportunities to help ... Responsibilities : • Own and coordinate the production process for recurring Research Team ...
Research Associate Downstream Process Development information
What is a research associate downstream process development?
A Research Associate in Downstream Process Development works within biotechnology or pharmaceutical companies to optimize and scale up the purification and recovery of biological products, such as proteins or antibodies, after initial production. They focus on processes like filtration, chromatography, and centrifugation to ensure product quality and yield. These professionals design experiments, analyze data, and support the transfer of processes from laboratory scale to manufacturing. Their work is crucial for developing efficient, reproducible, and regulatory-compliant methods for producing biopharmaceuticals.
What are the key skills and qualifications needed to thrive as a research associate in downstream process development?
To thrive as a Research Associate in Downstream Process Development, you need a solid background in biochemistry, molecular biology, or chemical engineering, often demonstrated by a bachelor's or master's degree in a related field. Familiarity with chromatography systems (such as AKTA), filtration technologies, and Good Manufacturing Practice (GMP) standards, along with data analysis software, is typically required. Strong problem-solving skills, attention to detail, and effective teamwork and communication abilities help individuals excel in this role. These competencies are crucial for ensuring efficient, scalable purification processes and maintaining product quality in biopharmaceutical development.
What are the typical challenges faced by a research associate in downstream process development, and how can they be addressed?
A Research Associate in Downstream Process Development often encounters challenges such as optimizing purification processes for new biologics, troubleshooting equipment issues, and ensuring scalability from laboratory to production scale. Effective communication with cross-functional teams, such as upstream scientists and analytical specialists, is essential to resolve issues quickly. Staying current with new purification technologies and maintaining meticulous documentation can also help address these challenges and support successful process development.
What is the difference between Research Associate Downstream Process Development vs Research Associate Upstream Process Development?
| Aspect | Research Associate Downstream Process Development | Research Associate Upstream Process Development |
|---|---|---|
| Primary Focus | Purification, filtration, chromatography of bioproducts | Cell culture, media optimization, bioreactor operation |
| Skills & Certifications | Protein purification, chromatography techniques, GMP compliance | Cell culture, aseptic techniques, bioreactor handling |
| Work Environment | Laboratory, manufacturing, quality control | Laboratory, bioprocessing facilities |
| Industry Usage | Biopharmaceutical manufacturing, biotech research | Biopharmaceutical development, biotech research |
While both roles support bioprocess development, Research Associate Downstream Process Development focuses on purification and filtration of bioproducts, whereas Research Associate Upstream Process Development emphasizes cell culture and bioreactor processes. Understanding these differences helps candidates align their skills with the appropriate role in biopharmaceutical production.
What cities in Pennsylvania are hiring for Research Associate Downstream Process Development jobs?
Cities in Pennsylvania with the most Research Associate Downstream Process Development job openings:
Associate Scientist, Process Development
Philadelphia, PA • On-site
Cabaletta Bio Inc.
• Biotechnology Research and Development • 11 - 50 employees11 - 50 employees
Full-time
PTO
Posted 29 days ago
Job description
Position Title: Associate Scientist, Process Development
Location: Philadelphia, PA, On-Site
Cabaletta Bio (Nasdaq: CABA) is a late-stage clinical biotechnology company focused on developing and launching curative targeted cell therapies designed specifically for patients with autoimmune diseases. The CABA™ platform encompasses two complementary strategies which aim to advance the discovery and development of engineered T cell therapies with the potential to become deep and durable, perhaps curative, treatments for a broad range of autoimmune diseases. The lead CARTA (Chimeric Antigen Receptor T cells for Autoimmunity) strategy is prioritizing the development of rese-cel, a 4-1BB-containing fully human CD19-CAR T cell investigational therapy. Rese-cel is currently being evaluated in the RESET™ (REstoring SElf-Tolerance) clinical development program spanning multiple therapeutic areas, including rheumatology, neurology and dermatology. Cabaletta Bio's headquarters and labs are located in Philadelphia, PA. For more information, please visit www.cabalettabio.com and connect with us on LinkedIn.
Uniquely Differentiated. Rapid. Elegant.
At Cabaletta, we are driven by the shared mission of developing cures, where a patients' own cells are used to fight disease. We are building a culture grounded in the knowledge that successful cures can be achieved for patients if every member of the Cabaletta is focused on the success of the team. To nurture this, we make an active commitment to the well-being and continuous growth of each employee who joins the team. In this way, we are not only working to improve the lives of patients, but of everyone involved. #CabalettaCrew.
We're proud to be a Great Place to Work-Certified™ company! #GPTWcertified Check out what our employees say makes working here so great: Working at Cabaletta Bio Inc | Great Place to Work®
About the Position:
The Associate Scientist, Process Development (PD) will be responsible for refinement, development, and assist in transfer of product candidates through to Cabaletta's cell therapy CDMOs. This position will work very closely with internal stakeholders (e.g. MSAT, Analytical Development, QA, Regulatory, supply chain), external manufacturing partners, and require up to 10% domestic travel or occasional weekend and overtime work.
Responsibilities:
Required Qualifications:
Our name - Cabaletta - is derived from the operatic term that represents a rapid, repetitive, and technically challenging section of an operatic aria, designed to showcase the skills of the lead singer. Analogously, Cabaletta Bio strives to achieve rapid and repetitive product development, building on our indication prioritization and biologic platform that targets the driver of specific autoimmune diseases without the need for long-term immunosuppression.
For more information, please visit https://www.cabalettabio.com/join-our-crew
Our most important asset is our people, and we offer competitive benefits, PTO, and stock option plans.
Cabaletta Bio is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability, protected veteran status or any other basis protected by applicable law.
Cabaletta Bio, Inc. does not accept unsolicited resumes from recruiters, employment agencies, or staffing firms. To conduct business with Cabaletta, a Master Services Agreement (MSA) must be executed and confirmed prior to submitting any information relating to a potential candidate. Without a signed MSA, Cabaletta shall not be responsible to any individual or entity for any payment relating to any form of fee or compensation.
And, if a resume or candidate is submitted by a recruiter, an employment agency, or a staffing firm without a fully executed MSA, Cabaletta has the unrestricted right to pursue and hire any of those candidate(s) without any legal or financial responsibility to the recruiter, agency, and/or firm.
#LI-ONSITE
Location: Philadelphia, PA, On-Site
Cabaletta Bio (Nasdaq: CABA) is a late-stage clinical biotechnology company focused on developing and launching curative targeted cell therapies designed specifically for patients with autoimmune diseases. The CABA™ platform encompasses two complementary strategies which aim to advance the discovery and development of engineered T cell therapies with the potential to become deep and durable, perhaps curative, treatments for a broad range of autoimmune diseases. The lead CARTA (Chimeric Antigen Receptor T cells for Autoimmunity) strategy is prioritizing the development of rese-cel, a 4-1BB-containing fully human CD19-CAR T cell investigational therapy. Rese-cel is currently being evaluated in the RESET™ (REstoring SElf-Tolerance) clinical development program spanning multiple therapeutic areas, including rheumatology, neurology and dermatology. Cabaletta Bio's headquarters and labs are located in Philadelphia, PA. For more information, please visit www.cabalettabio.com and connect with us on LinkedIn.
Uniquely Differentiated. Rapid. Elegant.
At Cabaletta, we are driven by the shared mission of developing cures, where a patients' own cells are used to fight disease. We are building a culture grounded in the knowledge that successful cures can be achieved for patients if every member of the Cabaletta is focused on the success of the team. To nurture this, we make an active commitment to the well-being and continuous growth of each employee who joins the team. In this way, we are not only working to improve the lives of patients, but of everyone involved. #CabalettaCrew.
We're proud to be a Great Place to Work-Certified™ company! #GPTWcertified Check out what our employees say makes working here so great: Working at Cabaletta Bio Inc | Great Place to Work®
About the Position:
The Associate Scientist, Process Development (PD) will be responsible for refinement, development, and assist in transfer of product candidates through to Cabaletta's cell therapy CDMOs. This position will work very closely with internal stakeholders (e.g. MSAT, Analytical Development, QA, Regulatory, supply chain), external manufacturing partners, and require up to 10% domestic travel or occasional weekend and overtime work.
Responsibilities:
- Execute process development experimental plans, provide associated protocols and final reports as needed, and present updates and data to teams.
- Design and execute Design of Experiments (DoE) studies to support process improvement, process characterization, and evaluate their impact on critical quality attributes (CQAs) and process performance.
- Support phase-appropriate cell therapy production processes using QbD principles.
- Assist the transfer of process to CDMOs for cGMP clinical manufacturing.
- Develop and review electronic Batch Records (eBRs) to support clinical manufacturing, ensuring alignment with process requirements, manufacturing procedures, and GMP expectations.
- Accurately capture data in a timely manner, ensuring data integrity and protocol compliance.
- Maintain all individual training requirements in a compliant state.
- Identify and evaluate new technologies to improve manufacturing outcomes such as: reduced costs, increased throughput, and enhanced quality.
- Coordinate with internal groups and external partners, scheduling and tracking clinical patient material/product shipping and receiving, troubleshooting associated issues.
- Maintain laboratory material and sample inventory, support the planning of MS&T process development materials needs and coordinate purchasing with lab manager.
Required Qualifications:
- B.S. with 3 + years or M.S. with 1 + years' experience within process development and manufacturing under cGMP processes.
- Previous experience and working knowledge of T-cells or immunological cell therapies.
- Experience with cell therapy manufacturing scale up, technology transfer, and process development and optimization is required.
- Experience in process automation is a plus.
- Experience in flow cytometry and cell-based bioassays is a plus.
- Good working knowledge in cGMP manufacturing of biological process and ICH regulations.
- Good coordination and communication skills are required.
- Highly organized and efficient, able to work independently. Strong problem-solving skill is preferred.
- Ability to coordinate parallel tasks across multiple projects, demonstrating prioritization.
Our name - Cabaletta - is derived from the operatic term that represents a rapid, repetitive, and technically challenging section of an operatic aria, designed to showcase the skills of the lead singer. Analogously, Cabaletta Bio strives to achieve rapid and repetitive product development, building on our indication prioritization and biologic platform that targets the driver of specific autoimmune diseases without the need for long-term immunosuppression.
For more information, please visit https://www.cabalettabio.com/join-our-crew
Our most important asset is our people, and we offer competitive benefits, PTO, and stock option plans.
Cabaletta Bio is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability, protected veteran status or any other basis protected by applicable law.
Cabaletta Bio, Inc. does not accept unsolicited resumes from recruiters, employment agencies, or staffing firms. To conduct business with Cabaletta, a Master Services Agreement (MSA) must be executed and confirmed prior to submitting any information relating to a potential candidate. Without a signed MSA, Cabaletta shall not be responsible to any individual or entity for any payment relating to any form of fee or compensation.
And, if a resume or candidate is submitted by a recruiter, an employment agency, or a staffing firm without a fully executed MSA, Cabaletta has the unrestricted right to pursue and hire any of those candidate(s) without any legal or financial responsibility to the recruiter, agency, and/or firm.
#LI-ONSITE
About Cabaletta Bio
Sourced by ZipRecruiter
Industry
Biotechnology research and development
Company size
11 - 50 Employees
Headquarters location
Philadelphia, PA, US
Year founded
2017