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Research Associate Downstream Process Development Jobs in California

Debut Biotech

Staff Process Engineer

San Diego, CA · On-site

Significant experience in downstream process development for fermentation-derived products, with ... The R&D laboratory will result in exposure to hot and cold temperatures, noise, fumes, limited dust ...

Debut Biotech

Staff Process Engineer

San Diego, CA · On-site

Significant experience in downstream process development for fermentation-derived products, with ... The R&D laboratory will result in exposure to hot and cold temperatures, noise, fumes, limited dust ...

BioTalent

Laboratory Technician

Tustin, CA · On-site

$19.61 - $24.51/hr

🚀 Laboratory Technician, Process Development Downstream 📍 Tustin, CA | On-site 🗓 Monday ... 🎓 Associate Degree (AA) in Life Sciences and relevant laboratory experience required. 🧪 ...

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Research Associate Downstream Process Development information

What is a research associate downstream process development?

A Research Associate in Downstream Process Development works within biotechnology or pharmaceutical companies to optimize and scale up the purification and recovery of biological products, such as proteins or antibodies, after initial production. They focus on processes like filtration, chromatography, and centrifugation to ensure product quality and yield. These professionals design experiments, analyze data, and support the transfer of processes from laboratory scale to manufacturing. Their work is crucial for developing efficient, reproducible, and regulatory-compliant methods for producing biopharmaceuticals.

What are the key skills and qualifications needed to thrive as a research associate in downstream process development?

To thrive as a Research Associate in Downstream Process Development, you need a solid background in biochemistry, molecular biology, or chemical engineering, often demonstrated by a bachelor's or master's degree in a related field. Familiarity with chromatography systems (such as AKTA), filtration technologies, and Good Manufacturing Practice (GMP) standards, along with data analysis software, is typically required. Strong problem-solving skills, attention to detail, and effective teamwork and communication abilities help individuals excel in this role. These competencies are crucial for ensuring efficient, scalable purification processes and maintaining product quality in biopharmaceutical development.

What are the typical challenges faced by a research associate in downstream process development, and how can they be addressed?

A Research Associate in Downstream Process Development often encounters challenges such as optimizing purification processes for new biologics, troubleshooting equipment issues, and ensuring scalability from laboratory to production scale. Effective communication with cross-functional teams, such as upstream scientists and analytical specialists, is essential to resolve issues quickly. Staying current with new purification technologies and maintaining meticulous documentation can also help address these challenges and support successful process development.

What is the difference between Research Associate Downstream Process Development vs Research Associate Upstream Process Development?

AspectResearch Associate Downstream Process DevelopmentResearch Associate Upstream Process Development
Primary FocusPurification, filtration, chromatography of bioproductsCell culture, media optimization, bioreactor operation
Skills & CertificationsProtein purification, chromatography techniques, GMP complianceCell culture, aseptic techniques, bioreactor handling
Work EnvironmentLaboratory, manufacturing, quality controlLaboratory, bioprocessing facilities
Industry UsageBiopharmaceutical manufacturing, biotech researchBiopharmaceutical development, biotech research

While both roles support bioprocess development, Research Associate Downstream Process Development focuses on purification and filtration of bioproducts, whereas Research Associate Upstream Process Development emphasizes cell culture and bioreactor processes. Understanding these differences helps candidates align their skills with the appropriate role in biopharmaceutical production.

What cities in California are hiring for Research Associate Downstream Process Development jobs?

Cities in California with the most Research Associate Downstream Process Development job openings:

Research Associate Downstream Process Development jobs near you
Infographic showing various Research Associate Downstream Process Development job openings in California as of September 2026, with employment types broken down into 33% Full Time, and 67% Contract. Highlights an 100% In-person job distribution.

ECO Process Development Research Associate II/III

Redwood City, CA • On-site

Codexis Inc
Biotechnology Research and Development • 201 - 500 employees
Learn more about Codexis Incexternal

Full-time

Medical, Dental, Vision, Life, Retirement, PTO

Re-posted 26 days ago

Job description

Description
Codexis, a biotechnology company based in Redwood City, CA, is looking to hire a ECO Process Development Research Associate II/III.

 Codexis is a leading enzyme engineering company leveraging its proprietary CodeEvolver® technology platform to discover, develop and enhance novel, high-performance enzymes and other classes of proteins. Codexis enzymes solve for real-world challenges associated with small molecule pharmaceuticals manufacturing and nucleic acid synthesis. The Company is currently developing its proprietary ECO Synthesis™ platform to enable the scaled manufacture of RNAi therapeutics through an enzymatic route. Codexis enzymes can drive improvements, such as higher yields, reduced energy usage and waste generation, improve efficiency in manufacturing and greater sensitivity in genomic and diagnostic applications.  
To meet the goals we’ve set for ourselves, we look for individuals who are driven, eager to grow and ready to embrace meaningful challenges. We empower employees to be authentic, ambitious, agile and have the courage to take action where they can make a positive impact. 
Come join us on this journey to transform the enzyme engineering landscape for the betterment of human health.

About the Opportunity The Process Development Research Associate I will join the Process Development group which is part of the TechOps department. Successful candidates will be a part of a dynamic and enthusiastic team responsible for development, scale up and tech transfer of the ECO Synthesis™ platform. The individual will be working with a high performing team with day-to-day laboratory workflows and operations to help with design, optimization, and analysis of ECO Synthesis™ technology. The position is an on-site role located at our Redwood City facility full time. 
If any of the below describes you, we would love to meet you!
  • Possess a passion for being part of the therapeutic community helping bring cutting edge treatments to patients in need. 
  • Enjoys collaboration across different functional groups to get a holistic understanding of process development along with aligning data with internal stakeholders.
  • Enjoys problem solving by implementing engineering and analytical solutions. 

In this role you will be responsible for:
  • Assist in the development and optimization of advanced analytical workflows, focusing on High-Performance Liquid Chromatography (HPLC).
  • Contribute to the development and enhancement of post-synthesis tangential flow filtration methods to ensure product quality.
  • Follow established protocols and procedures to conduct experiments, maintaining accurate and detailed records.
  • Collaborate with cross-functional teams to troubleshoot and resolve technical challenges.
  • Maintain laboratory equipment and ensure compliance with safety and quality standards.


The essential requirements of the job include:
  • Bachelor’s degree in Life Sciences or Chemistry with 2+ years of experience, or a Master’s degree.
  • Basic understanding of laboratory techniques.
  • Experience with High-Performance Liquid Chromatography (HPLC) is a plus.
  • Strong attention to detail and ability to follow protocols with supervision.

Additional experience that would be valuable for this role includes:
  • Excellent organizational and communication skills.
  • Ability to work effectively in a collaborative, team-oriented environment.

CODEXIS PAY TRANSPARENCY: The anticipated salary range for candidates who will work in Redwood City is $36.00 to $45.65/hour for an II and $89,000 to $121,000 for a III. The final salary offered to a successful candidate will be dependent on several factors that may include but are not limited to the type and length of experience within the job, type and length of experience within the industry, education, etc. Codexis is a multi-state employer, and this salary range may not reflect positions that work in other states​.

What can Codexis offer you?
  • Medical, Dental and Vision Insurance 
  • Basic Life, AD&D, Short- and Long-Term Disability Insurance 
  • 401k with Company Match up to 4% 
  • Company Equity 
  • Generous Paid Time Off including 18 Company Holidays (with a summer and winter shutdown), Vacation, and Wellness Time 
  • Annual Lifestyle Account for reimbursement of fitness programs, equipment and more 
  • Employee Stock Purchase Program (ESPP) 
  • Flexible Spending Accounts (Commuter/Parking, Dependent Care & Healthcare)
  • Student Debt Program (Company Contribution to Loans)
  • Mental Health Wellness Program
  • Subsidized onsite lunch program
  • Onsite Gym Facilities
  • Paid Parental Leave
  • And More!