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Job DescriptionThe Clinical Imaging Scientist (Principal Scientist) leads complex imaging deliverables for assigned clinical trials, applying scientific, technical, and operational imaging expertise to ensure quality, compliance, and timely achievement of critical milestones. The Clinical Imaging Scientist (CIS) will lead imaging strategy for approximately 15-25 global clinical trials across early- and late-stage development and multiple therapeutic areas, supporting programs from study planning through closeout.The CIS supports clinical teams in the effective use of medical imaging in clinical trials, ensuring high-quality execution and delivery of imaging-related objectives. In addition, the CIS leads scientific, operational, and process improvement initiatives that enhance the effectiveness and efficiency of clinical development programs. This position works closely with the Head of Clinical Imaging, Imaging Leads, Senior Clinical Imaging Scientists, and other Clinical Imaging Scientists to support the portfolio and provide scientific and operational leadership internally and externally, as follows: Provide day-to-day leadership and oversight of key imaging deliverables across assigned clinical trials Partner with internal stakeholders and external collaborators, including imaging vendors and specialty providers, to ensure seamless execution and support of imaging components within clinical trials Develop and maintain subject matter expertise in one or more disease areas, supporting internal and external teams while leveraging and advancing standards, best practices, and efficiencies across the portfolio Design and recommend imaging approaches, standards, and process improvements that strengthen clinical imaging support for assigned disease areas and development programs Apply scientific judgment and technical expertise to resolve complex imaging-related challenges across internal functions and external imaging service providers Develop, execute, and oversee imaging strategies supporting early- and late-stage clinical development programs Exercise independent judgment and strategic foresight in planning, organizing, and guiding complex imaging initiatives and projects Provide primary operational oversight of imaging processes, design imaging methodologies and standards, and author key imaging-related documents and study deliverables Collaborate across departments to advance imaging capabilities, improve operational efficiency, and challenge existing practices when appropriate to foster innovation Drive the development and implementation of imaging standards, approaches, and process improvements that contribute to the future direction of clinical imaging support Evaluate and recommend emerging technologies, imaging methodologies, and supporting systems to enhance imaging strategy and trial execution Partner with Quality and Compliance organizations to support quality-related decisions, vendor oversight activities, and internal or external audits involving imaging service providers Provide regulatory-facing imaging expertise to support health authority interactions, filing activities, and imaging-related components of regulatory strategy Apply knowledge of global regulatory expectations and industry best practices to support imaging-related questions associated with drug development and regulatory submissions. Represent the company in clinical imaging through participation at scientific meetings, industry forums, and professional organizations Lead and contribute to cross-functional initiatives focused on process improvement, imaging strategy, innovation, and organizational effectiveness, identifying solutions and recommending actionable paths forward that align with company objectives Demonstrate working proficiency with enterprise-approved digital, data, and AI tools relevant to the role Apply automation and data-driven approaches in day-to-day work Hold and maintain Global Clinical Trial Operations (GCTO) Elevate - Beginner (minimum) within first 6 months in role; progress to role-appropriate tier annually QualificationsEducation Minimum Requirement Bachelor's degree or higher level of education required Required Experience and Skills Minimum of 10 years of experience supporting clinical development within the pharmaceutical, biotechnology, or clinical research industry Strong knowledge of the application of medical imaging in clinical trials for efficacy and safety assessments Demonstrated experience serving as a primary imaging subject matter expert for clinical studies Experience authoring and reviewing clinical imaging operational and scientific documents supporting imaging endpoints and assessments Proven ability to resolve complex scientific and operational imaging challenges in clinical development programs Experience contributing to the development, evaluation, and refinement of imaging approaches supporting clinical development strategies Demonstrated ability to apply scientific judgment to address complex imaging-related clinical trial issues and risks Experience advancing imaging standards, process improvements, technology evaluations, or strategic initiatives supporting clinical development Experience supporting regulatory submissions, health authority interactions, and imaging related aspects of drug filings Preferred Experience and Skills Certification, training, or professional experience in one or more clinical imaging modalities, including experience as a radiologic technologist, at an imaging Clinical Research Organization (CRO), imaging core laboratory, or pharmaceutical sponsor Experience working with or overseeing external imaging vendors, imaging core laboratories, and specialty service providers Experience advising cross-functional study teams on imaging strategy and implementation Experience collaborating across functional groups to improve and implement processes supporting complex imaging deliverables Experience supporting imaging components of regulatory submissions and responses to health authority questions Demonstrated understanding of emerging imaging technologies, quantitative imaging approaches, and industry trends relevant to drug development Experience leading strategic, operational, or scientific initiatives with broad organizational impact clinicaltrialjobseligibleforERPRequired Skills: Clinical Development, Clinical Imaging, Clinical Programs, Clinical Research, Clinical Trial Oversight, Clinical Trial Planning, Cross-Functional Teamwork, Dedication to Patient Care, Drug Development, Ethical Standards, New Technology Integration, Operational Efficiency, Organizational Effectiveness, Organizational LeadershipPreferred Skills: Clinical Studies, Emerging Technologies, Global Regulatory, Strategic Initiative, Strategic ThinkingCurrent Employees apply HERE Current Contingent Workers apply HERE US and Puerto Rico Residents Only:Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process. As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics.--As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities.- For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:EEOC Know Your Rights EEOC GINA Supplement• We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively.Learn more about your rights, including under California, Colorado and other US State Acts The salary range for this role is $173,200.00 - $272,600.00This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee's position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs.The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.We offer a comprehensive package of benefits.- Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at https://jobs.merck.com/us/en/compensation-and-benefits .You can apply for this role through https://jobs.merck.com/us/en (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting. San Francisco Residents Only: -We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance Los Angeles Residents Only: -We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance Search Firm Representatives Please Read Carefully-Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. -No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.-Employee Status: RegularRelocation:No relocationVISA Sponsorship:No Travel Requirements: 10%Flexible Work Arrangements:RemoteShift:1st - DayValid Driving License:NoHazardous Material(s):N/AJob Posting End Date:08/16/2026 *A job posting is effective until 11:59:59PM on the day BEFORE -the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date. Requisition ID:R410800 Salary: . Date posted: 08/11/2026