Reliability Engineer Manager Jobs in Pennsylvania

This position is on-site in Philadelphia

About Proscia

Proscia is revolutionizing pathology, the last major frontier in healthcare to embrace digital. As a leader in pathology AI software, we are empowering pathologists and scientists to transition from traditional microscope-based workflows to digital, AI-driven approaches, unlocking new possibilities in precision medicine.

The digital pathology market is experiencing explosive growth as advances in AI enable unprecedented insights into diseases like cancer. Pathology is central to medicine, and the shift to AI-powered solutions is not just modernizing workflowsits transforming how diseases are diagnosed, treated, and understood. Predictions for the future of pathology show a tidal wave of adoption, with experts describing the field as poised for the next major breakthrough in healthcare innovation.

Backed by over $100 million in funding from leading healthcare and technology investors, Proscia is at the forefront of this revolution. Joining Proscia means being part of a company at the cutting edge of healthcare innovation, where the possibilities are limitless. With the convergence of AI, precision medicine, and digital pathology, were not just changing pathologywere redefining whats possible in medicine.

About This Position

As a Reliability Engineer reporting to the VP, Technical Operations, you will own the reliability, performance, and operational excellence of Proscias installations at customer sites. Our platform powers high-resolution digital pathology and AI-assisted workflows/diagnostics in clinical and research environments, often running on customer-managed infrastructure. Youll ensure these deployments are stable, performant, secure, and continuously improving. AI tools are a natural part of how you diagnose, automate, and operate.

This is a hands-on role with a focus on container-based deployments, systems performance, and real-world operational problem-solving in environments where rigor matters.

What Youll Do

Working at a startup like Proscia means wearing many hats, but when you come to work you can expect to focus on the following:

• Deploy, configure, and support Proscias container based application stack in on-premise customer environments.
• Own system reliability across customer installations, including uptime, performance, backup/recovery, and upgrade workflows.
• Diagnose and resolve production incidentsdeep root cause analysis across application, container, host, storage, and networking layers, using AI alongside traditional debugging to correlate signals and cut through noise.
• Optimize performance for large image datasets and AI workloads running on customer-managed compute infrastructure.
• Improve installation automation, configuration management, and repeatability across diverse environments integrating agentic workflows in your day-to-day to keep pace with demands from Engineering.
• Develop and refine monitoring, logging, and alerting patterns appropriate for customer-hosted deployments.
• Collaborate closely with Engineering, Customer Success, and Support to translate field learnings into product and operational improvements.
• Create operational playbookswritten with the clarity and structure that makes them useful to teammates, customers, and the AI-augmented workflows the team relies on.
• Contribute to Proscias technical presencewhether through internal demos, engineering blog posts, or operational knowledge sharing that raises the bar for how the team works.

About You

You think in systemsyou reason about how applications, infrastructure, and customer environments interact, not just the layer youre working in. AI tools are part of how you operate: troubleshooting, writing automation, navigating the complexity of diverse on-premise environments.

• Deep hands-on experience deploying and operating containerized applications using container orchestration in production environments.
• Strong Linux systems expertise (process management, networking, storage, security hardening, performance tuning)
• Expert troubleshooting skills in distributed systems across application, container, and infrastructure layers.
• Experience with enterprise networkingyou can troubleshoot and recommend corrections in customer infrastructure. Comfortable operating software in customer-managed and on-premise environments.
• Experience supporting data-intensive systems, ideally involving large image files or compute-heavy workloads.
• Working knowledge of observability practices (logs, metrics, tracing) and pragmatic monitoring approaches in non-cloud-native environments.
• Comfort working directly with customers or customer-facing teams to resolve high-impact issues.
• You already use AI tools in your operational work, in troubleshooting, writing automation, analyzing logs, or however it fits your practice.
• A mindset aligned with Proscias values: ownership, speed, simplification, and a willingness to challenge the status quo.
• Experience building with or on top of LLMs, AI agents, or agentic pipelines.
• Demonstrated fluency applying AI tools to real operational problems beyond basic code completion.
• Familiarity with prompt engineering, tool use patterns, and evaluation of AI systemsyou know when AI output is production-ready and when it needs different guardrails.

Nice to Have

• Experience with healthcare or regulated environments.
• Exposure to Kubernetes (for hybrid or future-state deployments).
• Experience with infrastructure automation or configuration management tools.
• Familiarity with database performance tuning for large datasets.
• Experience supporting GPU-enabled workloads.
• Open-source contributions, side projects, or a portfolio that shows how you think and build.
• Background that spans multiple domains or disciplines
• Active in technical communities, forums, or meetups.

Beyond Just Work

As a company in healthcare, we want our people to be happy and healthy, in and out of the office. In addition to competitive pay, we ensure everyone on our team is supported with savings, schedule, and insurance options that promote long-term health and personal growth.

Our office environment is designed for creativity and agility: with walls as notepads and couches for collaboration. Were located in the heart of Philadelphia, with views of the city so you can spend your time focusing on what matters most.

At Proscia, we dont just accept differences we celebrate them, we support them, and we thrive on them for the benefit of our employees, our products, and our community. Proscia is proud to be an equal opportunity workplace.