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Quality System Compliance Manager Jobs (NOW HIRING)

LSMA Management Inc

Compliance Manager

San Bernardino, CA · Hybrid

$95K - $125K/yr

The Compliance Manager partners cross-functionally with Legal, Regulatory, Privacy, Quality, and Operations to implement compliance initiatives, manage risk, and support audit readiness. Requirements ...

Boeing

Quality System Specialist

Auburn, WA · On-site

$125K - $170K/yr

Conducts hardware, software and system level audits to determine compliance with quality management system standards, configuration assurance, related business, regulatory and customer requirements ...

Alkegen

Compliance Manager

Buffalo, NY · On-site

Manage and respond to customer regulatory requests related to product compliance or other ... Quality to gather product composition and hazard data. * Support implementation of systems for ...

Addison Group

Compliance Manager

Houston, TX · On-site

$100K/yr

Compliance Manager Location: Houston, TX Employment Type: Direct Hire Pay: $100,000.00+ DOE ... The Manager will also perform quality control reviews, prepare reports, and provide recommendations ...

wafna

Compliance Manager

Santa Fe Springs, CA · On-site

Provide technical food safety and quality support during the innovation/development of products ... Establish and maintain systems for tracking changes in documentation. * Carry out the completion of ...

Hanwha Energy USA

Compliance Manager

Houston, TX · On-site

$120K - $150K/yr

With over a decade of experience delivering high-quality, utility-scale energy projects across ... Hanwha Renewables - specializing in utility-scale solar and battery energy storage systems (BESS)

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Quality System Compliance Manager information

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How much do quality system compliance manager jobs pay per year?

As of Jun 16, 2026, the average yearly pay for quality system compliance manager in the United States is $98,613.00, according to ZipRecruiter salary data. Most workers in this role earn between $75,500.00 and $122,500.00 per year, depending on experience, location, and employer.

What does a quality systems and compliance manager do?

A quality systems and compliance manager oversees the development, implementation, and maintenance of quality management systems to ensure products and processes meet industry standards and regulations. They conduct audits, analyze data, and implement corrective actions, often using tools like ISO standards and quality management software, to ensure ongoing compliance and continuous improvement.

What is the salary for a quality manager?

The salary for a Quality System Compliance Manager typically ranges from $70,000 to $120,000 annually, depending on experience, industry, and location. Professionals with certifications like CQE or Six Sigma may earn higher salaries, and the role often requires knowledge of quality management systems such as ISO 9001.

What is the role of a quality compliance manager?

A quality compliance manager oversees an organization’s adherence to industry standards, regulations, and internal policies to ensure product and service quality. They develop, implement, and monitor quality systems, conduct audits, and ensure compliance with certifications such as ISO, often using tools like quality management software. Strong knowledge of regulatory requirements and attention to detail are essential for this role.

How does a Quality System Compliance Manager typically collaborate with cross-functional teams to ensure regulatory adherence?

Quality System Compliance Managers routinely work with departments such as manufacturing, R&D, and regulatory affairs to align processes with quality standards and regulatory requirements. They facilitate regular meetings, provide training on compliance protocols, and lead audits to identify and address gaps. Effective communication and collaboration are essential, as these managers must interpret complex regulations and translate them into practical procedures for different teams. This cross-functional approach ensures that quality and compliance are integrated throughout the organization.

What is the difference between Quality System Compliance Manager vs Quality Assurance Specialist?

AspectQuality System Compliance ManagerQuality Assurance Specialist
CertificationsISO 9001 Lead Auditor, CQEASQ certifications, ISO 9001 awareness
Work EnvironmentRegulatory compliance, quality management systemsProduct testing, process inspection
Employer & IndustryManufacturing, healthcare, aerospaceManufacturing, software, consumer goods

The Quality System Compliance Manager focuses on ensuring organizational adherence to quality standards and regulatory requirements, often managing compliance programs. The Quality Assurance Specialist primarily conducts product testing and inspections to verify quality. While both roles aim to improve quality, the Compliance Manager emphasizes system-wide adherence, whereas the Specialist concentrates on product-level quality assurance.

Is QMS a good career?

A career as a Quality System Compliance Manager involves overseeing quality management systems (QMS) to ensure compliance with industry standards such as ISO 9001. It requires strong attention to detail, knowledge of regulatory requirements, and skills in audits and process improvement. This role offers opportunities for advancement in industries like manufacturing, healthcare, and technology, often with certifications like ISO auditor or Six Sigma enhancing career prospects.

What does a Quality System Compliance Manager do?

A Quality System Compliance Manager is responsible for ensuring that an organization’s processes and products meet regulatory and quality standards. They develop, implement, and maintain quality management systems, conduct audits, and ensure compliance with industry regulations such as ISO standards or FDA requirements. Their role often involves training staff on quality procedures, handling non-conformances, and facilitating continuous improvement initiatives to uphold product safety and efficacy.

What are the key skills and qualifications needed to thrive as a Quality System Compliance Manager, and why are they important?

To thrive as a Quality System Compliance Manager, you need a deep understanding of quality management systems, regulatory requirements (such as ISO 9001 or FDA regulations), and a relevant degree in science or engineering. Familiarity with audit software, document control systems, and certifications like Certified Quality Auditor (CQA) are typically expected. Strong analytical thinking, attention to detail, and effective communication enable success in cross-functional team environments. These competencies ensure organizational compliance, minimize risk, and drive continuous improvement in quality standards.
Infographic showing various Quality System Compliance Manager job openings in the United States as of June 2026, with employment types broken down into 1% As Needed, 81% Full Time, 15% Part Time, and 3% Contract. Highlights an 92% Physical, 2% Hybrid, and 6% Remote job distribution, with an average salary of $98,613 per year, or $47.4 per hour.
Associate Director, Computer System Validation & Quality Compliance

Associate Director, Computer System Validation & Quality Compliance

Amylyx Pharmaceuticals

Cambridge, MA • On-site, Remote

Other

Posted 8 days ago

Job description

The Opportunity

The Associate Director, Computer System Validation (CSV) & Quality Compliance provides enterpriselevel leadership, strategic direction, and governance for the validation, lifecycle management, and continuous compliance of GxPrelevant computerized systems, with a strong emphasis on the Veeva Quality Suite. This role ensures that digital quality solutions and supporting systems meet global regulatory requirements (FDA, EMA, ICH, GAMP 5), maintain data integrity, and enable a sustainable, inspectionready state across the organization.

This person will partner closely with Quality, IT, Regulatory, Clinical, and business process owners to define system requirements, lead new system implementations and major enhancements, and drive harmonized, riskbased validation practices. This role also oversees quality compliance processes such as Change Control, Deviations, CAPA, and continuous improvement, ensuring timely closure, trend analysis, and effective governance through leadership of key forums including Quality Management Review and crossfunctional compliance meetings.

Responsibilities

Strategic Leadership & Governance

  • Develop, evolve, and steward the corporate CSV/CSA strategy, ensuring alignment with enterprise digital strategy and Quality Management System (QMS) objectives.
  • Serve as the senior Quality authority for computerized systems validation, data integrity, and electronic system compliance.
  • Oversee enterprise-wide governance programs, ensuring standardized, riskbased approaches to system implementation and maintenance.
  • Provide strategic guidance to senior leadership regarding system performance, risks, and compliance maturity.

Computer System Validation & Lifecycle Oversight

  • Lead planning, execution, review, and approval of validation deliverables across GxP systems.
  • Oversee system lifecycle activities including impact assessments, change management, periodic reviews, audit trails, user access reviews, and system retirement.
  • Promote and reinforce CSAaligned, riskbased validation practices to streamline compliance and maximize efficiency.
  • Ensure documentation quality and consistent application of SDLC principles across projects.

Veeva Systems Expertise & Optimization

  • Serve as the Quality SME for the Veeva Quality Suite, providing expert guidance on configuration, workflow optimization, and release readiness.
  • Lead implementation, enhancement, and optimization of Veeva Vault modules and crossfunctional integrations.
  • Drive automation and digitization initiatives that improve usability, compliance, and system performance.
  • Partner with IT and Veeva administrators to maintain robust, compliant change control processes.

Quality & Regulatory Compliance

  • Ensure all computerized systems maintain compliance with 21 CFR Part 11, EU Annex 11, GxP principles, and global data integrity expectations.
  • Author, revise, and own Quality System policies and procedures related to electronic systems and validation.
  • Represent Quality during internal audits, external regulatory inspections, and vendor assessments.
  • Lead timely remediation, effectiveness checks, and continuous improvement initiatives.
  • Provide oversight and trending for Quality Events related to system performance or compliance.

Required Qualifications

  • Bachelor's degree in a relevant scientific or technical discipline.
  • 8+ years of experience in the life sciences industry with strong GxP system experience.
  • Extensive leadership experience in cross functional implementation and validation of GxP computerized systems.
  • Deep expertise with Veeva Vault Quality Suite (QMS, Docs, Training, etc.).
  • Strong knowledge of global regulatory expectations and data integrity frameworks.
  • Demonstrated ability to lead enterprise programs, influence stakeholders, and drive compliant decision making.

Preferred Qualifications

  • Expertise with SaaS/cloud architectures and database compliance expectations.
  • Understanding of clinical data collection technologies and supporting data processes.
  • Familiarity with SDLC, Agile methodologies, CSV vs. CSA principles and automated testing platforms.
  • Experience developing and interpreting Quality metrics such as KPIs and KQIs.
  • Excellent communication skills with the ability to collaborate, negotiate, and influence at all organizational levels.

Work Location and Conditions

  • At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska, Arizona, Hawaii, Michigan and Tennessee.
  • You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company-related events as necessary and requested, which may include travel by air, driving or public transportation.
  • You must have access to work in setting that meets all requirements of the role (including privacy, reliable internet access, phone, ability to communication via video conference, etc.) at your remote location.

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