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Python Software Engineer Jobs in Boston, MA (NOW HIRING)

Code Metal

Principal Software Engineer - Python

Boston, MA

$146.70K - $196.60K/yr

Job Title Principal Software Engineer - Python AI Pipelines Overview We are looking for an experienced software engineer to help us build a new generation of transpilation tools enabled by AI and ...

Code Metal

Principal Software Engineer - Python

Boston, MA · On-site

$146.70K - $196.60K/yr

Job Title Principal Software Engineer - Python AI Pipelines Overview We are looking for an experienced software engineer to help us build a new generation of transpilation tools enabled by AI and ...

MORSE Corp

Autonomy Software Engineer

Cambridge, MA · On-site

$90K - $210K/yr

MORSE is looking for an Autonomy Software Engineer to research, develop and prototype novel ... Experience with C++ and Python software languages and software design best practices. * Experience ...

Code Metal

Senior Software Engineer - Rust and Python

Boston, MA · On-site

$133.10K - $175.50K/yr

We're looking for a Senior Software Engineer with strong Rust and Python expertise and a product-focused mindset to help build a new class of AI-powered transpilation and code generation tools. These ...

Code Metal

Senior Software Engineer - Rust and Python

Boston, MA · On-site

$133.10K - $175.50K/yr

We're looking for a Senior Software Engineer with strong Rust and Python expertise and a product-focused mindset to help build a new class of AI-powered transpilation and code generation tools. These ...

Code Metal

Senior Software Engineer - Rust and Python

Boston, MA · Hybrid

$133.10K - $175.50K/yr

We're looking for a Senior Software Engineer with strong Rust and Python expertise and a product-focused mindset to help build a new class of AI-powered transpilation and code generation tools. These ...

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How much do python software engineer jobs pay per year?

As of May 29, 2026, the average yearly pay for python software engineer in Boston, MA is $152,065.00, according to ZipRecruiter salary data. Most workers in this role earn between $120,000.00 and $178,700.00 per year, depending on experience, location, and employer.

What is a Python Software Engineer job?

A Python Software Engineer is a developer who designs, develops, and maintains software applications using the Python programming language. They work on a variety of tasks, including writing clean and efficient code, debugging, optimizing performance, and integrating third-party services or APIs. Python engineers often collaborate with teams to build web applications, data pipelines, machine learning models, or automation scripts, depending on the industry. Their role requires strong problem-solving skills and familiarity with software development best practices.

What are the key skills and qualifications needed to thrive in the Python Software Engineer position, and why are they important?

To thrive as a Python Software Engineer, you need strong programming skills in Python, a solid understanding of algorithms and data structures, and a relevant degree in computer science or related fields. Experience with frameworks like Django or Flask, familiarity with version control systems such as Git, and optional certifications like PCEP or PCAP can be valuable assets. Problem-solving skills, teamwork, and effective communication help you navigate complex projects and collaborate efficiently. Mastering both technical and soft skills is crucial for building reliable software solutions and succeeding in dynamic development teams.

What does a typical workday look like for a Python Software Engineer?

A typical workday for a Python Software Engineer involves writing and testing code, participating in team meetings to plan and review tasks, and collaborating with colleagues such as front-end developers, quality assurance engineers, and project managers. You may spend time troubleshooting bugs, reviewing pull requests, and improving existing software modules. Many teams use Agile or Scrum methodologies, so your day may include short stand-up meetings and iterative development cycles. Depending on the company, you might also have opportunities to contribute to design discussions or mentor junior developers.
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Python Software Engineer jobs near you
Staff Software Engineer (Python)

Staff Software Engineer (Python)

JetBridge

Boston, MA • On-site

Other

Posted 19 days ago

Job description

Referring a Candidate for a bounty? Please visit Refer a Dev to submit.
 
--
Help build the software platform that enables scientists to design and engineer living systems the same way engineers build modern software.
 
This company is developing a synthetic biology platform that allows scientists to design, simulate, and debug genetic systems at scale. Their technology combines biology, software engineering, and advanced computation to accelerate the development of next-generation therapeutics.
 
The team is building tools that transform biological engineering into a true engineering discipline. They are now hiring a Staff Software Engineer to help architect the core platform used by scientists and researchers to design complex biological systems.
 
The Role
You will play a key role in designing and evolving a platform used by bioengineers to design, search, and analyze genetic constructs. This is a highly technical role with significant architectural ownership.
 
You will collaborate closely with synthetic biologists, computational scientists, and product teams to build systems that model complex biological data and workflows.
 
The platform handles highly structured scientific data and requires thoughtful API design, scalable architecture, and robust backend systems.
 
What You'll Do
- Design and implement backend architecture that will shape the platform for years
- Build GraphQL APIs for querying and analyzing genetic construct data
- Develop services using Python, SQLAlchemy, and modern backend frameworks
- Architect complex data models representing biological systems
- Collaborate directly with scientists to understand workflows and translate them into software tools
- Design systems that scale as usage and data volume grow significantly
- Participate in on-call rotation and support production systems
 
What They're Looking For
- 10+ years building production-grade software systems
- Deep expertise in Python
- Experience designing APIs (GraphQL preferred)
- Strong experience designing scalable backend architectures
- Experience modeling complex data systems and relational databases
- Ability to make long-term architectural decisions
- Comfort working in highly ambiguous, first-of-its-kind product environments
- Strong collaboration skills across technical and scientific teams
 
Nice to have:
- Experience with GraphQL frameworks such as Strawberry
- Experience with SQLAlchemy or similar ORM tools
- Experience working with scientific, research, or highly complex datasets
 
Why This Role Stands Out
- Work on software that accelerates next-generation therapeutics
- Architect a platform used by scientists designing living systems
- High ownership and influence over system architecture
- Deep technical challenges involving complex biological data models
- Work at the intersection of biology, software engineering, and AI-driven research
 
If you enjoy designing systems from first principles and want your work to influence the future of biotechnology, this is a rare opportunity.
We may use artificial intelligence (AI) tools to support parts of the hiring process, such as reviewing applications, analyzing resumes, or assessing responses. These tools assist our recruitment team but do not replace human judgment. Final hiring decisions are ultimately made by humans. If you would like more information about how your data is processed, please contact us.
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