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Python Software Engineer Jobs in Minnesota (NOW HIRING)

Software Engineer - Hybrid

Rochester, MN

  • Medical

  • Dental

  • Vision

  • Retirement

Our Software Engineers ensures that these cloud-based micro-services adhere to uptime and accuracy ... Programming in high-level languages such as Go, Python, Java etc. Work on deployment automation ...

Proficient with C++, C# or Python * Experience with Agile software development * Experience with ... Preferred Skills: > GPU programming > 3D computer graphics with Robotics and Automated Systems ...

Software Engineer - Hybrid

Rochester, MN · On-site

  • Medical

  • Dental

  • Vision

  • Retirement

Programming in high-level languages such as Go, Python, Java etc. Work on deployment automation ... Have working knowledge and experience of Software Engineering with a minimum of internships and a ...

Senior Software Engineer

Maple Grove, MN · On-site

$125K - $165K/yr

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

  • PTO

Design, develop and maintain software solutions using programming / scripting languages such as C, C++, C#, and Python * Assist in creating and maintaining product documentation (requirements ...

Senior Software Engineer

Maple Grove, MN · On-site

$125K - $165K/yr

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

  • PTO

Design, develop and maintain software solutions using programming / scripting languages such as C, C++, C#, and Python * Assist in creating and maintaining product documentation (requirements ...

Senior Software Engineer

Maple Grove, MN · On-site

$125K - $165K/yr

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

  • PTO

Design, develop and maintain software solutions using programming / scripting languages such as C, C++, C#, and Python * Assist in creating and maintaining product documentation (requirements ...

Senior Software Engineer

Minneapolis, MN · On-site +1

$127K - $168K/yr

  • Medical

  • Life

  • Retirement

  • PTO

Senior Software Engineers are expected to use approved AI tools responsibly, lead by example, and ... Technical fluency in multiple programming languages, such as C#, Java, Groovy, Scala, Python ...

Posted today

$114K - $150K/yr

A Simulation Software Engineer plans, coordinates, and executes development of simulation tools ... Designing, coding, testing, and debugging logical and mathematical models (using C++, Python ...

Systems Software Engineer

Brooklyn Park, MN · On-site

$90K - $110K/yr

  • Medical

  • Dental

  • Vision

  • Retirement

  • PTO

The Software Engineer works closely with manufacturing, operations, supply chain, finance, and ... Experience with one or more modern application development stacks, such as: * C# * .NET * Python

Systems Software Engineer

Brooklyn Park, MN · On-site +1

$180K - $213K/yr

  • Medical

  • Dental

  • Vision

  • Retirement

  • PTO

The Software Engineer works closely with manufacturing, operations, supply chain, finance, and ... Experience with one or more modern application development stacks, such as: * C# * .NET * Python

Systems Software Engineer

Brooklyn Park, MN · On-site

$90 - $120/hr

  • Medical

  • Dental

  • Vision

  • Retirement

  • PTO

The Software Engineer works closely with manufacturing, operations, supply chain, finance, and ... Experience with one or more modern application development stacks, such as: * C# * .NET * Python

New

Systems Software Engineer

Minneapolis, MN · On-site

$90K - $110K/yr

  • Medical

  • Dental

  • Vision

  • Retirement

  • PTO

The Software Engineer works closely with manufacturing, operations, supply chain, finance, and ... NET Python JavaScript / TypeScript Or similar enterprise application technologies Strong SQL and ...

Showing results 21-40

Python Software Engineer information

See Minnesota salary details

$22.5K

$137.1K

$198.3K

How much do python software engineer jobs pay per year?

As of Aug 19, 2026, the average yearly pay for python software engineer in Minnesota is $137,089.00, according to ZipRecruiter salary data. Most workers in this role earn between $108,200.00 and $161,100.00 per year, depending on experience, location, and employer.

What is a Python software engineer?

A Python Software Engineer is a developer who designs, develops, and maintains software applications using the Python programming language. They work on a variety of tasks, including writing clean and efficient code, debugging, optimizing performance, and integrating third-party services or APIs. Python engineers often collaborate with teams to build web applications, data pipelines, machine learning models, or automation scripts, depending on the industry. Their role requires strong problem-solving skills and familiarity with software development best practices.

What does a Python software engineer do?

A typical workday for a Python Software Engineer involves writing and testing code, participating in team meetings to plan and review tasks, and collaborating with colleagues such as front-end developers, quality assurance engineers, and project managers. You may spend time troubleshooting bugs, reviewing pull requests, and improving existing software modules. Many teams use Agile or Scrum methodologies, so your day may include short stand-up meetings and iterative development cycles. Depending on the company, you might also have opportunities to contribute to design discussions or mentor junior developers.

What skills and qualifications are needed to be a Python software engineer?

To thrive as a Python Software Engineer, you need strong programming skills in Python, a solid understanding of algorithms and data structures, and a relevant degree in computer science or related fields. Experience with frameworks like Django or Flask, familiarity with version control systems such as Git, and optional certifications like PCEP or PCAP can be valuable assets. Problem-solving skills, teamwork, and effective communication help you navigate complex projects and collaborate efficiently. Mastering both technical and soft skills is crucial for building reliable software solutions and succeeding in dynamic development teams.

Are Python Software Engineers in demand?

Python Software Engineers are in high demand across various industries due to Python's versatility in web development, data analysis, machine learning, and automation. Employers seek professionals with strong programming skills, experience with frameworks like Django or Flask, and knowledge of data tools, making it a valuable skill set for many tech roles.

Can I be a Python Software Engineer with Python?

Yes, Python is the primary programming language used by Python Software Engineers. Proficiency in Python, along with knowledge of related tools like version control systems and frameworks, is essential for this role. Typically, a bachelor's degree in computer science or a related field and experience with software development are also required.

How much do Python software engineers make?

Python software engineers' salaries vary based on experience, location, and industry, but the median annual salary in many regions ranges from $80,000 to $130,000. Senior roles or those with specialized skills in frameworks like Django or data analysis can earn higher compensation, often exceeding $150,000 annually.

What are popular job titles related to Python Software Engineer jobs in Minnesota?

For Python Software Engineer jobs in Minnesota, the most frequently searched job titles are:

What job categories do people searching Python Software Engineer jobs in Minnesota look for?

The top searched job categories for Python Software Engineer jobs in Minnesota are:

What cities in Minnesota are hiring for Python Software Engineer jobs?

Cities in Minnesota with the most Python Software Engineer job openings:

What are popular job titles related to Python Software Engineer jobs in MN?

For Python Software Engineer jobs in MN, the most frequently searched job titles are:

Infographic showing various Python Software Engineer job openings in Minnesota as of August 2026, with employment types broken down into 1% As Needed, 84% Full Time, 10% Part Time, 4% Contract, and 1% Nights. Highlights an 87% Physical, 4% Hybrid, and 9% Remote job distribution, with an average salary of $137,089 per year, or $65.9 per hour.

Software Engineer - Hybrid

Mayo Clinic

Rochester, MN

Full-time

Medical, Dental, Vision, Retirement

Re-posted 5 hours ago


Mayo Clinic rating

7.8

Company rating: 7.8 out of 10

Based on 699 frontline employees who took The Breakroom Quiz

127th of 888 rated healthcare providers


Job description

Why Mayo Clinic

Mayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our employees, investing in competitive compensation and comprehensive benefit plans - to take care of you and your family, now and in the future. And with continuing education and advancement opportunities at every turn, you can build a long, successful career with Mayo Clinic.

Benefits Highlights
  • Medical: Multiple plan options.
  • Dental: Delta Dental or reimbursement account for flexible coverage.
  • Vision: Affordable plan with national network.
  • Pre-Tax Savings: HSA and FSAs for eligible expenses.
  • Retirement: Competitive retirement package to secure your future.

Responsibilities

The Cardiovascular Systems Unit is seeking a Software Engineer to support AI and research initiatives by operationalizing machine learning solutions, developing cloud-hosted applications, integrating clinical systems, and partnering with data scientists, researchers, and clinical stakeholders. Success in this role requires a highly flexible engineer who can navigate changing priorities, rapidly learn new technologies, and transform proof-of-concept solutions into production-ready systems.

These applications leverage cloud computing, big data, mobile, data science, data warehousing, machine learning using state of the art software development applications and frameworks. Our Software Engineers ensures that these cloud-based micro-services adhere to uptime and accuracy targets, are resilient, and scale as data volumes and traffic increase. They work closely with the data engineering, platform, and solutions teams to develop applications as required to benefit our practice and patients. 
Works closely with the Product Owners, Product Managers, Architects to translate requirements into code. Developing services around data warehousing, big data, cloud computing, business intelligence, analytics and machine learning. Participate in DevOps, Agile, continuous development and integration frameworks. Programming in high-level languages such as Go, Python, Java etc. Work on deployment automation/configuration management with tools including but not limited to ADO, Puppet, Chef or Ansible or Azure Pipelines, CloudFormation, Terraform following a DevOps model. Ensure all appropriate documentation of processes and source code is created and maintained. Communicate effectively with peers, leaders, and customers throughout the organization. Participate in expert level troubleshooting and resolve problems through root cause analysis, data and system investigation. Continues to build knowledge of the organization, processes and customers. Performs a range of mainly straightforward assignments. Uses prescribed guidelines or policies to analyze and resolve problems. Receives a moderate level of guidance and direction.


Qualifications

Bachelor's degree in Computer Science/Engineering or related field; Or an Associates' degree in Computer Science/Engineering or related field with an additional 2 years of experience as described below. 

  • Have working knowledge and experience of Software Engineering with a minimum of internships and a minimum of 1 yr. of experience, or 2yrs of experience coding applications or services in a high-level language (C, C++, Golang, Java, C# etc.). 
  • Demonstrated problem solving and time management skills. 
  • Possesses strong technical aptitude for designing and implementing software solutions. 
  • Experience with modern application development frameworks. 
  • Knowledge of professional software engineering practices & best practices for the full software development life cycle, including coding standards, code reviews, source control management, build processes, testing, and operations. 
  • Deep hands-on technical expertise, excellent verbal and written communication skills. 
  • Experience with Agile software development techniques. 
    Preferred Qualifications:
  • Experience with Microsoft Azure cloud technologies.
  • Experience developing with Python.
  • Experience with C#/.NET development.
  • Understanding of front-end application development
  • Experience with Docker and containerized deployments.
  • Familiarity with machine learning engineering concepts and model hosting.
  • Experience deploying and supporting software developed by data scientists in production environments
  • Knowledge of cloud platforms such as Azure and/or Google Cloud Platform.
  • 5-10 years of software engineering experience.
  • Experience working within clinical or healthcare systems.
  • Experience integrating systems and solving interoperability challenges.
  • Experience working within research environments and translating research solutions into operational tools
  • Experience supporting AI, analytics, or machine learning initiatives.
     

During the selection process you may participate in an OnDemand (pre-recorded) interview that you can complete at your convenience. During the OnDemand interview, a question will appear on your screen, and you will have time to consider each question before responding. You will have the opportunity to re-record your answer to each question - Mayo Clinic will only see the final recording. The complete interview will be reviewed by a Mayo Clinic staff member, and you will be notified of next steps.
This is a hybrid position and must be located within 100 miles of a Mayo Clinic campus for occasional on-site expectations based on business needs.
This vacancy is not eligible for sponsorship/we will not sponsor or transfer visas for this position.  Mayo Clinic DOES NOT participate in the F-1 STEM OPT extension program.


Exemption Status
Exempt
Compensation Detail
$97,448.00 - $143,270.40 / year
Benefits Eligible
Yes
Schedule
Full Time
Hours/Pay Period
80
Schedule Details
8:00am - 5:00pm, Monday-Friday. Evenings and weekends as needed. Participate in an on-call rotation. This is a hybrid position and must be located within 100 miles of a Mayo Clinic campus for occasional on-site expectations based on business needs.
Weekend Schedule
Weekends as needed.
International Assignment
No
Site Description
Just as our reputation has spread beyond our Minnesota roots, so have our locations. Today, our employees are located at our three major campuses in Phoenix/Scottsdale, Arizona, Jacksonville, Florida, Rochester, Minnesota, and at Mayo Clinic Health System campuses throughout Midwestern communities, and at our international locations. Each Mayo Clinic location is a special place where our employees thrive in both their work and personal lives. Learn more about what each unique Mayo Clinic campus has to offer, and where your best fit is. 

Equal Opportunity

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, gender identity, sexual orientation, national origin, protected veteran status or disability status. Learn more about the 'EOE is the Law'.  Mayo Clinic participates in E-Verify and may provide the Social Security Administration and, if necessary, the Department of Homeland Security with information from each new employee's Form I-9 to confirm work authorization.

Recruiter
Jackie MckayQualifications:

Bachelor's degree in Computer Science/Engineering or related field; Or an Associates' degree in Computer Science/Engineering or related field with an additional 2 years of experience as described below. 

  • Have working knowledge and experience of Software Engineering with a minimum of internships and a minimum of 1 yr. of experience, or 2yrs of experience coding applications or services in a high-level language (C, C++, Golang, Java, C# etc.). 
  • Demonstrated problem solving and time management skills. 
  • Possesses strong technical aptitude for designing and implementing software solutions. 
  • Experience with modern application development frameworks. 
  • Knowledge of professional software engineering practices & best practices for the full software development life cycle, including coding standards, code reviews, source control management, build processes, testing, and operations. 
  • Deep hands-on technical expertise, excellent verbal and written communication skills. 
  • Experience with Agile software development techniques. 
    Preferred Qualifications:
  • Experience with Microsoft Azure cloud technologies.
  • Experience developing with Python.
  • Experience with C#/.NET development.
  • Understanding of front-end application development
  • Experience with Docker and containerized deployments.
  • Familiarity with machine learning engineering concepts and model hosting.
  • Experience deploying and supporting software developed by data scientists in production environments
  • Knowledge of cloud platforms such as Azure and/or Google Cloud Platform.
  • 5-10 years of software engineering experience.
  • Experience working within clinical or healthcare systems.
  • Experience integrating systems and solving interoperability challenges.
  • Experience working within research environments and translating research solutions into operational tools
  • Experience supporting AI, analytics, or machine learning initiatives.
     

During the selection process you may participate in an OnDemand (pre-recorded) interview that you can complete at your convenience. During the OnDemand interview, a question will appear on your screen, and you will have time to consider each question before responding. You will have the opportunity to re-record your answer to each question - Mayo Clinic will only see the final recording. The complete interview will be reviewed by a Mayo Clinic staff member, and you will be notified of next steps.
This is a hybrid position and must be located within 100 miles of a Mayo Clinic campus for occasional on-site expectations based on business needs.
This vacancy is not eligible for sponsorship/we will not sponsor or transfer visas for this position.  Mayo Clinic DOES NOT participate in the F-1 STEM OPT extension program.


What Mayo Clinic employees say

Pay

Benefits

Hours and flexibility

Workplace

Get the full story on Breakroom


Mayo Clinic logo

About Mayo Clinic

Sourced by ZipRecruiter

Mayo Clinic is the largest integrated, not-for-profit medical group practice in the world. We're building the future, one where the best possible care is available to everyone — and more people can heal at home. Our relentless research turns into earlier diagnoses and new cures. That's how we inspire hope in those who need it most. At Mayo Clinic, experts work together to solve the most challenging unmet needs of patients. Our history of innovation dates back almost 150 years, when brothers Will and Charlie Mayo pioneered an integrated, team-based approach to medicine. Today, that trailblazing spirit drives innovations like Mayo Clinic Platform — which powers new technologies to change how care is delivered to all.

Industry

Hospitals

Company size

10,000+ Employees

Headquarters location

Rochester, MN, US

Year founded

1919