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Python Programmer Jobs in O Fallon, IL (NOW HIRING)

Sr. Elastic Engineer

Scott Air Force Base, IL · On-site

$110K - $151K/yr

... Python, PowerShell, Bash, etc.) to streamline operations, data processing, and monitoring. - Deploy Elastic across platforms, including on-premises, public cloud (AWS, Azure, Google Cloud Platform ...

Cloud Engineer

Saint Louis, MO · On-site

$52.25 - $69.75/hr

As a cloud engineer you will build and automate highly available, elastic, and secure cloud-based ... Proficiency in one or more common infrastructure automation languages (Shell Scripting, Python ...

Cloud Engineer

Saint Louis, MO · On-site

$52.25 - $69.75/hr

As a cloud engineer you will build and automate highly available, elastic, and secure cloud-based ... Proficiency in one or more common infrastructure automation languages (Shell Scripting, Python ...

You will leverage senior-level Python programming skills to build production-ready tools, automate manual processes, and develop reusable analytic capabilities. Your work will include designing ...

Write, develop, and deploy robust code across the full stack, utilizing languages such as Python ... Consult with engineering staff to evaluate interface between hardware and software. * Correct ...

Software Engineer

Saint Louis, MO · On-site +1

$100K/yr

Software Engineer (Azure Cloud, Data Engineering & Automation) | Hybrid - St. Louis, MO We are ... Most of our services are serverless (Azure Functions in Python and TypeScript), our warehouse is ...

Software Engineer (Azure Cloud, Data Engineering & Automation) Hybrid - St. Louis, MO We are ... Most of our services are serverless (Azure Functions in Python and TypeScript), our warehouse is ...

DevOps Engineer

Saint Louis, MO · On-site

$87K - $157K/yr

Write and maintain Python scripts to automate tasks, streamline workflows, and support system ... AWS certification (e.g. DevOps Engineer, Solutions Architect) * Experience with ArcGIS or ...

Showing results 41-60

Python Programmer information

See O Fallon, IL salary details

$37

$63

$77

How much do python programmer jobs pay per hour?

As of Aug 6, 2026, the average hourly pay for python programmer in O'Fallon, IL is $63.53, according to ZipRecruiter salary data. Most workers in this role earn between $58.32 and $67.26 per hour, depending on experience, location, and employer.

Are Python programmers in demand?

Python programmers are in high demand across various industries due to the language's versatility, ease of learning, and widespread use in data analysis, web development, and automation. Employers often seek candidates with skills in frameworks like Django or Flask and familiarity with libraries such as Pandas or NumPy, making Python a valuable skill for software development roles.

What are the key skills and qualifications needed to thrive as a Python programmer, and why are they important?

To thrive as a Python Programmer, you need strong proficiency in Python programming, understanding of algorithms, and a background in computer science or related fields. Familiarity with development tools like Git, testing frameworks such as PyTest, and experience with libraries like Django or Flask are typically required. Problem-solving ability, attention to detail, and effective teamwork are standout soft skills for this role. These skills ensure the development of reliable, scalable software solutions and smooth collaboration within technical teams.

What do Python programmers do?

A Python programmer uses the programming language called Python to write code for various applications, including big data manipulation, web servers, program scripting, and more. In this career, the software allows you to program quicker using fewer lines, which creates an easy-to-read code. You can find work in web or game development, data visualization, and analyzing data, among others. Your job duties vary based on your specialization, but they usually include working with files and extensive support libraries, creating, testing and implementing new or updated applications, and examining the code to spot problems.

What are some common challenges Python programmers face when working on large-scale projects, and how can they overcome them?

Python Programmers working on large-scale projects often encounter challenges such as managing code maintainability, optimizing performance, and coordinating with cross-functional teams. To address these, it’s essential to follow best practices like modular programming, using virtual environments, and employing version control systems such as Git. Regular code reviews and clear communication within the team help maintain code quality and ensure everyone is aligned. Leveraging frameworks and libraries effectively can also streamline development and reduce repetitive tasks.

What is the difference between Python Programmer vs Software Developer?

AspectPython ProgrammerSoftware Developer
Required CredentialsTypically a degree in Computer Science or related field; proficiency in PythonDegree in Computer Science or related; proficiency in multiple programming languages including Python
Work EnvironmentOften in tech companies, startups, or freelance projects focused on Python-based tasksIn various industries, working on full software solutions, often across multiple languages and platforms
Employer & Industry UsageTech firms, data analysis, automation projectsSoftware firms, IT departments, app development

While a Python Programmer specializes in Python coding, a Software Developer works on broader software solutions, often using multiple languages. Both roles require similar foundational skills, but Software Developers typically handle more comprehensive project responsibilities.

What is a Python programmer?

Python Programmers are software developers who specialize in writing code using the Python programming language. They design, develop, and maintain applications or systems, often working on tasks such as web development, data analysis, machine learning, automation, and scripting. Python Programmers need strong problem-solving skills and a good understanding of programming concepts. They often collaborate with other developers, data scientists, and stakeholders to build efficient and scalable solutions.

What jobs can a Python programmer do?

A Python programmer can work in roles such as software developer, data analyst, data scientist, machine learning engineer, web developer, automation engineer, and backend developer. These roles often require knowledge of frameworks like Django or Flask, libraries such as Pandas or TensorFlow, and proficiency in coding, debugging, and version control tools like Git.
What cities near O'Fallon, IL are hiring for Python Programmer jobs? Cities near O'Fallon, IL with the most Python Programmer job openings:
Infographic showing various Python Programmer job openings in O'Fallon, IL as of August 2026, with employment types broken down into 2% Internship, 83% Full Time, 8% Part Time, 6% Contract, and 1% Nights. Highlights an 81% Physical, 5% Hybrid, and 14% Remote job distribution, with an average salary of $132,139 per year, or $63.5 per hour.

$110K - $165K/yr

Full-time

Medical, Retirement, PTO

Posted 15 days ago


Job description

Work Your Magic with us!Start your next chapter and join MilliporeSigma.

Ready to explore, break barriers, and discover more? We know you've got big plans - so do we! Our colleagues across the globe love innovating with science and technology to enrich people's lives with our solutions in Healthcare, Life Science, and Electronics. Together, we dream big and are passionate about caring for our rich mix of people, customers, patients, and planet. That's why we are always looking for curious minds that see themselves imagining the unimaginable with us.

This role does not offer sponsorship for work authorization. External applicants must be eligible to work in the US.


Your Role:

We are looking for a StaffApplied AIEngineer to build scalable, production-grade backend applications that leverage large and complex datasets. This role is software engineering first, with a strong emphasis on designing reliable systems that ingest, process, and serve data to power modern applications and AI-driven solutions.

You will work closely with product managers, software engineers, data scientists, and ML engineers to build robust backend services, data-intensive applications, and production AI systems. Success in this role requires strong software engineering fundamentals, practical experience working with data throughout its lifecycle, and the ability to design systems that are scalable, maintainable, and reliable in production.

Essential Job Functions:

  • Lead technical strategy for AI/LLM systems across multiple products
  • Architect retrieval, orchestration, agentic, and evaluation systems that run reliably in production
  • Set the standards for AI safety, evaluation, observability, and responsible rollout in aregulatedcontext
  • MentorJunior-level engineers into strong AI engineers;Employ AI Native development skills to multiply the productivity (Claude, etc.)
  • Lead the frontier: evaluate new models, techniques, and tools, and bring the right ones into the team
  • Design, develop, and maintain scalable Python applications and backend services.
  • Build systems that ingest, validate, transform, and manage structured and unstructured data in production environments.
  • Design data models and storage solutions that support scalable, high-performance applications.
  • Develop reusable components for data processing, validation, enrichment, and feature generation.

Who You Are

Minimum Qualifications:

  • Bachelor's degree in Computer Science, Engineering, Data Science, or a related quantitative field.
  • At least 3 years of hands-on experience in machine learning, data science, search relevance, or ranking systems.

Preferred Qualifications:

  • 10+ years of software engineering experience, with deep recent time leading production AI/LLM systems
  • Proven expertise in Python and ML frameworks (MLFlow,TensorFlow,PyTorch, Scikit- learn, or equivalent).
  • Strong background in statistical analysis, data exploration, and working with large-scale datasets.
  • Experience with feature engineering, data preprocessing, and data
  • Seasoned hands-on coder; still writes production Python regularly
  • Seasoned system designer for AI systems at scale - retrieval, agents, evaluation, latency, and cost, vector databases/pipelines
  • Strong experience building and maintaining production-grade backend applications.
  • Experience designing and developing RESTful APIs and distributed systems.
  • Strong SQL skills and experience working with relational databases; familiarity with NoSQL databases or modern data storage technologies is a plus.
  • Solid understanding of data engineering fundamentals, including data quality, validation, transformation, modeling, and efficient storage.
  • Experience designing systems that process large datasets reliably and efficiently.
  • Experience with cloud platforms such as Google Cloud Platform (GCP) or AWS.
  • Experience using Docker, Git, CI/CD pipelines, automated testing frameworks, and modernsoftware engineering best practices.
  • Core engineering stack
  • Languages: Python,REST API, Pandas, NumPy
  • Cloud and infrastructure: AWSServicesand/or GCP, Kubernetes, Bedrock
  • Distributed systems: event-driven architectures, including Kafka
  • Orchestration Frameworks:LangGraph,LangChain,AirFlow, etc.
  • Vector Databases likeQdrant

Nice to have Skills:

  • Experience with Kubernetes and container orchestration.
  • Familiarity with event-driven architectures and messaging platforms such as Kafka.
  • Familiarity with ML model deployment and inference pipelines

Location

This role can be based in either our St. Louis, MO or Burlington, MA office and requires a weekly onsite presence

Pay Range for this position: $110,500 - $165,900. The offer range represents the anticipated low and high end of the base pay compensation for this position. The actual compensation offered will be determined by factors such as location, level of experience, education, skills, andother job-related factors. Position may be eligible for sales or performance-based bonuses. Benefits offered by the Company include health insurance, paid time off (PTO), retirement contributions, and other perquisites. For more information click here:https://careers.emdgroup.com/us/en/benefits


What we offer: We are curious minds that come from a broad range of backgrounds, perspectives, and life experiences. We believe that this variety drives excellence and innovation, strengthening our ability to lead in science and technology. We are committed to creating access and opportunities for all to develop and grow at your own pace. Join us in building a culture of inclusion and belonging that impacts millions and empowers everyone to work their magic and champion human progress!

Apply now and become a part of a team that is dedicated to Sparking Discovery and Elevating Humanity!

Employment Type: FULL_TIME