Protein Engineering Jobs in Ohio (NOW HIRING)

Battelle delivers when others can't. We conduct research and development, manage national laboratories, design and manufacture products and deliver critical services for our clients-whether they are a multi-national corporation, a small start-up or a government agency.
We recognize and appreciate the value and contributions of individuals from a wide range of backgrounds and experiences and welcome all qualified individuals to apply.
Job Summary
Battelle is seeking a highly qualified Translational Scientist to provide scientific leadership and product development planning for the Non-Viral Gene Delivery Program. This role will be responsible for advancing scientific strategy, leading cross-functional development efforts, and driving the translation of non-viral delivery technologies from concept through development milestones with a focus on cystic fibrosis treatments. The successful candidate will bring deep expertise in cystic fibrosis disease biology, inhalation delivery technology, molecular and cellular biology, and translational development, along with the ability to lead technical teams and shape program direction. Depending on experience and demonstrated leadership capabilities, this position may be filled at the Sr. Scientist and/or Research Leader level.
The role is in Columbus, OH.
Responsibilities

• Provide scientific and technical leadership for Battelle's non-viral gene delivery research and product development activities with a focus on therapies targeting cystic fibrosis.
• Lead development planning for new platform technologies, products, and applications related to non-viral delivery of nucleic acid cargo, including DNA, RNA, mRNA, siRNA, CRISPR components, and other biologic payloads.
• Define and execute program strategies, technical roadmaps, and milestone-based development plans with a focus on inhalation delivery technologies that are non-viral in nature.
• Design, oversee, and interpret studies related to inhalation delivery efficiency, cell target specificity, intracellular trafficking, biodistribution, safety, and efficacy.
• Serve as a technical leader across multidisciplinary teams including biology, chemistry, materials science, formulation, bioanalytics, manufacturing, quality, regulatory, and business development.
• Guide experimental design, data analysis, risk assessment, and technical decision-making to support platform maturation and product advancement.
• Identify and evaluate emerging technologies, competitive approaches, and partnership opportunities relevant to non-viral gene delivery.
• Contribute to technical reports, proposals, intellectual property strategy, scientific publications, and customer-facing presentations, as appropriate.
• Mentor junior scientists and support development of scientific talent within the program.
• Support transition of technologies from early research into translational and product development phases.
• Ensure activities are conducted in accordance with applicable quality, safety, and regulatory expectations.

Key Qualifications

• Ph.D. in Molecular Biology, Cell Biology, Biomedical Engineering, Biochemistry, Genetics, Chemical Engineering, or a related life sciences field.
• Master's degree with significant directly relevant experience may be considered.

Required Technical Skills and Experience

• Strong scientific background in non-viral gene delivery technologies, nucleic acid therapeutics, or closely related drug delivery technologies for inhalation routes of exposure.
• Demonstrated expertise in one or more of the following: lipid nanoparticles or lipid-based delivery systems; polymeric or biomaterial-based delivery systems; nanoparticle formulation and characterization; intracellular delivery of nucleic acids or gene-editing cargos; cell targeting and uptake mechanisms.
• Experience in molecular and cellular biology techniques such as transfection and gene expression assays, qPCR, ddPCR, RT-qPCR, flow cytometry, ELISA, microscopy, cell-based functional assays, and western blotting or related protein analysis methods.
• Experience designing and leading in vitro and/or in vivo studies to evaluate inhalation delivery system performance, biological activity, and safety.
• Ability to integrate toxicology and efficacy data with formulation, analytical, and development objectives.
• Experience with experimental planning, data interpretation, troubleshooting, and technical decision-making in a fast-paced R&D environment.
• Strong written and verbal communication skills, including the ability to present complex technical concepts clearly to internal and external stakeholders.
• Demonstrated ability to work effectively in cross-functional teams.

Leadership / Program Skills

• Experience leading technical projects, workstreams, or scientific teams focused on cystic fibrosis drug candidate development and/or inhalation drug delivery technologies.
• Ability to translate scientific goals into actionable development plans, timelines, and milestone-based deliverables.
• Strong organizational and project management capabilities.

Preferred Qualifications

• Industry experience in gene therapy, nucleic acid therapeutics, advanced biologics, inhalation drug delivery, and translational product development.
• Experience advancing technologies beyond discovery into preclinical development, product planning, or commercialization readiness.
• Familiarity with CMC considerations, manufacturability, scale-up, formulation development, and analytical characterization for delivery platforms.
• Knowledge of regulatory expectations for biologics, gene delivery systems, or combination products.
• Experience with CRISPR/Cas systems, mRNA therapeutics, oligonucleotide delivery, or other genome engineering applications.
• Experience in biodistribution, PK/PD, toxicology, and translational biology for delivery platforms.
• Track record of scientific publications, patents, proposal development, or funded programs.
• Experience supporting client-facing technical discussions, strategic partnerships, or business development efforts.
• Demonstrated success mentoring scientists and influencing scientific direction across teams.

Leveling Guidance
T4 Biological Scientist

• Established technical contributor with strong subject matter expertise in non-viral gene delivery via the inhalation/aerosol route of administration.
• Capable of independently leading significant technical workstreams and contributing to program strategy.
• May supervise junior staff or lead matrixed teams on specific projects.
• Typically requires a Ph.D. with approximately 6+ years of relevant experience, or a Master's degree with approximately 10+ years of relevant experience.

T5 Biological Scientist

• Recognized scientific leader with broad and deep expertise in non-viral gene delivery, translational science, and inhalation drug product development strategy.
• Responsible for shaping program direction, influencing portfolio decisions, and leading complex, cross-functional initiatives.
• Expected to serve as a senior technical authority, mentor, and external-facing scientific leader.
• Typically requires a Ph.D. with approximately 10+ years of relevant experience, or a Master's degree with approximately 14+ years of relevant experience.

Core Competencies

• Scientific leadership
• Strategic thinking
• Product development planning
• Cross-functional collaboration
• Innovation and problem-solving
• Technical communication
• Decision-making under uncertainty
• Mentorship and team development

Compensation Data
Battelle is committed to fair and equitable compensation practices. The salary range for this role is $99,200 - $141,400 per year, in addition to our comprehensive benefits package. A candidate's salary is determined by various factors, including but not limited to education, relevant work experience, skills, and certifications. Salary ranges may vary based on geographic location and market conditions.
Benefits: Live an Extraordinary Life
We care about your well-being, not just on the job. Battelle offers comprehensive and competitive benefits to help you live your best life.

• Balance life through a compressed work schedule: Most of our team follows a flexible, compressed work schedule that allows for every other Friday off-giving you a dedicated day to accomplish things in your personal life without using vacation time.
• Enjoy enhanced work flexibility, including a hybrid arrangement: You have options for where and when you work. Our Together with Flexibility model allows you to work 60% in-office and 40% remote, with Monday and Tuesday as common in-office days, dependent on team and position needs .
• Take time to recharge: You get paid time off to support work-life balance and keep motivated.
• Prioritize wellness: Stay healthy with medical, dental, and vision coverage with wellness incentives and benefits plus a variety of optional supplemental benefits.
• Better together: Coverage for partners, gender-affirming care and health support, and family formation support.
• Build your financial future: Build financial stability with an industry-leading 401(k) retirement savings plan. For most employees, we put in 5 percent whether you contribute or not, and match your contributions on top of that.
• Advance your education: Tuition assistance is available to pursue higher education.

A Work Environment Where You Succeed
For brilliant minds in science, technology, engineering and business operations, Battelle is the place to do the greatest good by solving humanity's most pressing challenges and creating a safer, healthier and more secure world.
You will have the opportunity to thrive in a culture that inspires you to:

• Apply your talent to challenging and meaningful projects
• Receive select funding to pursue ideas in scientific and technological discovery
• Partner with world-class experts in a collaborative environment
• Nurture and develop the next generation of scientific leaders
• Give back to and improve our communities

Vaccinations & Safety Protocols
Battelle may require employees, based on job duties, work location, and/or its clients' requirements to follow certain safety protocols and to be vaccinated against a variety of viruses, bacteria, and diseases as a condition of employment and continued employment and to provide documentation that they are fully vaccinated. If applicable, Battelle will provide reasonable accommodations based on a qualified disability or medical condition through the Americans with Disabilities Act or the Rehabilitation Act or for a sincerely held religious belief under Title VII of the Civil Rights Act of 1964 (and related state laws).
Battelle is an equal opportunity employer. We provide employment and opportunities for advancement, compensation, training, and growth according to individual merit, without regard to race, color, religion, sex (including pregnancy), national origin, sexual orientation, gender identity or expression, marital status, age, genetic information, disability, veteran-status veteran or military status, or any other characteristic protected under applicable Federal, state, or local law. Our goal is for each staff member to have the opportunity to grow to the limits of their abilities and to achieve personal and organizational objectives. We will support positive programs for equal treatment of all staff and full utilization of all qualified employees at all levels within Battelle.
The above statements are intended to describe the nature and level of work being performed by people assigned to this job. They are not intended to be an exhaustive list of all responsibilities, activities and skills required of staff members. No statement herein is intended to imply any authorities to commit Battelle unless special written permission is granted by Battelle's Legal Department.
For more information about our other openings, please visit www.battelle.org/careers