ZipRecruiter

Log In

1

Process Chemistry Jobs in Madison, WI (NOW HIRING)

Merck Group

Manufacturing Supervisor

Madison, WI · On-site

$85K - $136K/yr

Apply strong knowledge of synthetic and process chemistry to support manufacturing activities. * Coordinate cross-department workflow to ensure timely completion of manufacturing projects and PD ...

Merck Group

Process Safety Engineer

Verona, WI · On-site

$75K - $120K/yr

Knowledge of the following chemical processes; bioprocessing, organic chemistry, inorganic chemistry, combustible dusts and other volatile solvents. Pay Range for this position: $75,300 - $120,700 ...

SHINE Technologies LLC

Senior R&D Chemist

Janesville, WI · On-site

$75K - $120K/yr

Work closely with multidisciplinary teams in chemistry, process engineering, and licensing to develop innovative UNF recycling solutions. * Maintain and calibrate key analytical and radioanalytical ...

SHINE Technologies LLC

Senior R&D Chemist

Janesville, WI · On-site

$75K - $120K/yr

Work closely with multidisciplinary teams in chemistry, process engineering, and licensing to develop innovative UNF recycling solutions. * Maintain and calibrate key analytical and radioanalytical ...

SHINE Technologies, LLC

Senior R&D Chemist

Janesville, WI · On-site

$75K - $120K/yr

Work closely with multidisciplinary teams in chemistry, process engineering, and licensing to develop innovative UNF recycling solutions. * Maintain and calibrate key analytical and radioanalytical ...

next page

Showing results 1-20

All JobsProcess Chemistry JobsProcess Chemistry Jobs in Madison, WI

Process Chemistry information

See Madison, WI salary details

$13

$24

$35

How much do process chemistry jobs pay per hour?

As of Aug 1, 2026, the average hourly pay for process chemistry in Madison, WI is $24.59, according to ZipRecruiter salary data. Most workers in this role earn between $19.66 and $28.03 per hour, depending on experience, location, and employer.

What are some common challenges faced by process chemists in scaling up reactions from the laboratory to manufacturing?

Process chemists often encounter challenges when transitioning chemical reactions from small-scale laboratory experiments to large-scale manufacturing. These challenges include ensuring consistent product quality, managing heat transfer and mixing issues, and addressing safety concerns that may not be apparent at a smaller scale. Close collaboration with engineers, quality control teams, and safety specialists is essential to address these complexities and optimize the process for commercial production. Effective troubleshooting and adaptability are key skills for success in this role.

What is the highest paid chemist job?

The highest paid chemist roles are often in pharmaceutical or industrial sectors, such as senior research scientists or chemical engineering managers, with salaries exceeding $150,000 annually. These positions typically require advanced degrees, extensive experience, and expertise in specialized techniques or regulatory compliance.

What is process chemistry?

Process chemistry is a branch of chemistry focused on the development, optimization, and scale-up of chemical processes for manufacturing substances, typically in the pharmaceutical or chemical industries. Process chemists work to make chemical reactions safer, more efficient, cost-effective, and environmentally friendly when moving from laboratory scale to large-scale production. Their responsibilities often include troubleshooting, improving yields, and ensuring regulatory compliance during manufacturing. This field is crucial for bringing new chemical products from research and development to market.

What are the key skills and qualifications needed to thrive as a Process Chemist, and why are they important?

To thrive as a Process Chemist, you need a solid background in organic and analytical chemistry, typically with a bachelor's or advanced degree in chemistry or chemical engineering. Familiarity with laboratory instruments (e.g., HPLC, GC, NMR), process scale-up techniques, and safety regulations is essential, and certifications like OSHA training can be advantageous. Strong problem-solving skills, attention to detail, and effective teamwork are key soft skills for success. These competencies ensure safe, efficient development and optimization of chemical processes, which are crucial for high-quality, scalable manufacturing.

What is the difference between Process Chemistry vs Chemical Engineering?

AspectProcess ChemistryChemical Engineering
Required CredentialsBachelor's in Chemistry or related field, possibly a master'sBachelor's in Chemical Engineering, often with a master's or higher
Work EnvironmentLaboratories, R&D settings, pilot plantsIndustrial plants, manufacturing facilities, process design
Industry UsagePharmaceuticals, specialty chemicals, research labsPetrochemicals, large-scale manufacturing, process optimization

Process Chemistry focuses on developing and optimizing chemical reactions and formulations, often in research and development settings. Chemical Engineering involves designing and managing large-scale chemical processes and production systems. While both roles require chemistry knowledge, Process Chemists are more research-oriented, whereas Chemical Engineers focus on process scale-up and plant operations.

What does a process chemist do?

A process chemist develops, optimizes, and scales chemical manufacturing processes to ensure efficient, safe, and cost-effective production of chemicals or pharmaceuticals. They analyze data, troubleshoot issues, and work with laboratory and production teams to improve process performance, often using specialized tools like chromatography and spectrometry. Strong knowledge of chemistry, safety protocols, and regulatory standards is essential in this role.

How much do process chemists make in the US?

Process chemists in the US typically earn a median annual salary of around $70,000 to $100,000, depending on experience, education, and industry. Salaries can increase with specialized skills, certifications, and working in high-demand sectors such as pharmaceuticals or specialty chemicals.

Can a chemist be a process engineer?

A chemist can transition into a process engineer role, especially if they gain experience in process design, optimization, and manufacturing. Process engineering often requires knowledge of chemical processes, equipment, and safety protocols, which chemists typically develop through on-the-job training or additional coursework. Both roles involve understanding chemical reactions and production processes, making the transition feasible with relevant skills and experience.
What job categories do people searching Process Chemistry jobs in Madison, WI look for? The top searched job categories for Process Chemistry jobs in Madison, WI are:
Process Chemistry jobs near you
Infographic showing various Process Chemistry job openings in Madison, WI as of July 2026, with employment types broken down into 100% Full Time. Highlights an 100% In-person job distribution, with an average salary of $51,152 per year, or $24.6 per hour.

Scientist III, Process Chemistry (Antibody-siRNA Conjugates)

Arrowhead Pharmaceuticals

Madison, WI

$110K - $125K/yr

Full-time

Re-posted 5 days ago

Job description

Arrowhead Pharmaceuticals, Inc. (Nasdaq ARWR) is a commercial stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead's RNAi-based therapeutics leverage this natural pathway of gene silencing.

Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.

Arrowhead's corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.

The Position

Arrowhead Pharmaceuticals is seeking a motivated Scientist III to join our Process Chemistry team, focused on the development and scale-up of conjugated RNAi therapeutics. This role centers on process development for antibody-siRNA conjugates (AOCs/ARCs), a key expansion of Arrowhead's TRiM platform into targeted extrahepatic delivery. The successful candidate will span the full development continuum - taking discovery-stage conjugation protocols, optimizing them for robustness and reproducibility, and developing them into GMP, kilogram-scale manufacturing processes. This is a hands-on role at the bench combined with oversight of external CRO/CDMO partners.

Responsibilities

  • Optimize discovery-stage conjugation protocols for antibody-siRNA conjugates, improving yield, reproducibility, and product quality to enable scale-up.
  • Develop GMP-ready, kilogram-scale conjugation processes, including site-specific and stochastic conjugation strategies, linker chemistry, and payload attachment.
  • Work hands-on in the laboratory to design, execute, and optimize conjugation reactions, purification (chromatography, TFF/UF-DF), and analytical control strategies.
  • Oversee and direct CROs/CDMOs executing process development and manufacturing activities, including setting technical direction, reviewing data, and ensuring timelines and quality standards are met.
  • Characterize conjugates for DAR/siRNA-to-antibody ratio, aggregation, charge heterogeneity, and stability using relevant analytical methods (e.g., HIC, SEC, IEX, LC-MS, AEX).
  • Lead technology transfer to internal and external manufacturing partners, authoring process descriptions, batch records, and development reports.
  • Troubleshoot process and analytical challenges; design experiments to define process parameters, ranges, and robustness for kilogram-scale operation.
  • Collaborate cross-functionally with discovery chemistry, linker/conjugation chemistry, analytical development, and CMC teams

Requirements

  • PhD in Organic Chemistry, Bioconjugate Chemistry, Chemical Engineering, or a related field; or a Bachelor's/Master's degree with commensurate hands-on industry experience.
  • Demonstrated hands-on experience in siRNA conjugation development is required.
  • Working knowledge of oligonucleotide and/or antibody chemistry, linker design, and bioconjugation methods.
  • Familiarity with purification and analytical characterization of conjugates.
  • Strong problem-solving, documentation, and communication skills.

Preferred

  • Experience with antibody-oligonucleotide conjugates (AOCs) or antibody-drug conjugates (ADCs).
  • Experience developing and scaling processes to GMP/kilogram scale and managing CRO/CDMO relationships.
  • Knowledge of site-specific conjugation technologies (e.g., engineered cysteines, enzymatic/click chemistry).
  • Experience with tech transfer and CMC/GMP environments.
Wisconsin pay range
$110,000—$125,000 USD

Arrowhead provides competitive salaries and an excellent benefit package.

Candidates must have current, valid authorization to work in the country where this role is located.

California Applicant Privacy Policy