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Principal Clinical Database Programmer Jobs in Massachusetts

Vrtx

Principal Statistical Programmer

Boston, MA · Remote

$149K - $223K/yr

The Principal Statistical Programmer works with management to delegate tasks appropriately, track ... Solves complex clinical trial reporting problems and demonstrates technical proficiency and ...

Venus Consultancy

Principal AI Engineer

Cambridge, MA · On-site

Principal Engineer (Backend / Platform)About Us We are a Cambridge, MA-based rapidly scaling ... Graph databases (Neo4j) for modeling complex relationships * Vector databases and embeddings ...

Blitzy

Principal Software Engineer

Cambridge, MA · On-site

$300 - $500/hr

The Role We are hiring a Principal Engineer to take full, hands‑on ownership of Blitzy's most ... Graph databases (Neo4j) for modeling and searching complex relationships * Vector databases ...

Scorpion Therapeutics

Director, Safety Sciences

Boston, MA · On-site

$235 - $255/hr

... and Programming to develop safety strategies/analyses. * Prepare/review safety sections of ... CTD/eCTD; clinical database/EDC; safety database queries. * Manage/mentor junior team; lead safety ...

Recorded Future

Principal Software Engineer

Boston, MA · On-site

$152K - $228K/yr

As a Principal Software Engineer, you will work across application code and infrastructure to ... Experience with SQL databases such as Postgres or AWS RDS, and NoSQL databases such as MongoDB or ...

Appian Corporation

Principal Consultant

Boston, MA · On-site

$100K - $225K/yr

We are seeking a Principal Technical Consultant to join our Customer Success team. In this role ... Basic understanding of object oriented programming, experience working with relational databases ...

Appian Corporation

Principal Consultant

Boston, MA · On-site

$225K/yr

We are seeking a Principal Technical Consultant to join our Customer Success team. In this role ... Basic understanding of object oriented programming, experience working with relational databases ...

Cytel

Principal Biostatistician FSP

Cambridge, MA · On-site +1

An experienced Principal Biostatistician with a passion for clinical development and analysis ... Oversight of internal programming activities and/or CRO contributions on assigned clinical trials ...

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How much do principal clinical database programmer jobs pay per hour?

As of Sep 6, 2026, the average hourly pay for principal clinical database programmer in Massachusetts is $92.35, according to ZipRecruiter salary data. Most workers in this role earn between $79.57 and $106.59 per hour, depending on experience, location, and employer.

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Cities in Massachusetts with the most Principal Clinical Database Programmer job openings:

Principal Statistical Programmer

Vrtx

Boston, MA • Remote

$149K - $223K/yr

Full-time

Medical, Dental, Vision, Retirement, PTO

Re-posted 11 days ago

Job description

Job Description

General Summary:

The Principal Statistical Programmer works with management to delegate tasks appropriately, track progress, and provide expert technical support to team members. In addition, the Principal Statistical Programmer is a designated member of clinical sub-team(s) in the role of project lead Statistical Programmer.

Key Duties and Responsibilities:

  • Works regularly with advanced features of SAS (including interfacing ability with other software applications and operating system tools)

  • Performs quality control checks of SAS code and output produced by other Statistical Programmers to ensure accuracy and consistency within group

  • Demonstrates in-depth knowledge of clinical development and medical data

  • Solves complex clinical trial reporting problems and demonstrates technical proficiency and exercises judgment in supporting daily operations and ensuring that study tasks are completed accurately and in a timely manner

  • Engages with a variety of other functions, including Statistical Programmers, Biostatisticians, Data Management, and other departments engaged in providing data and submission-related activities, often at Senior Management levels

  • Creates all files, documents, and analyses necessary to support an electronic submission in eCTD format, including ISS/ISE

  • Provides leadership to ensure compliance with Vertex SOP'S and FDA/ICH/GCP regulations

  • Provides technical and project management skills to create, review, and approve documentation required to support data analysis, reporting, and CDlSC data submission

  • Participates in project management cross-functional teams that work on standard operating procedures, guidelines, process improvements, system validation and acquisition, customization, and integration of new tools and technologies

Knowledge and Skills:

  • Proficiency in all SAS language, procedures, and functions commonly used in clinical trial reporting including the Macro language, BASE SAS, SAS/STAT and SAS/GRAPH

  • Intermediate knowledge of CDISC Standards

  • Intermediate knowledge of clinical trials

  • Regulatory submission experiences

  • Effective communication (written and verbal) skills to explain difficult information

Education and Experience:

  • Bachelors degree in a Scientific Discipline

  • Typically requires 5+ for M.S. or above and 8+ years for B.S. years of work experience in Biotech, Pharmaceuticals or Clinical Research Organization

Pay Range:

$149,200 - $223,800

Disclosure Statement:

The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

Flex Designation:

Remote-Eligible

Flex Eligibility Status:

In this Remote-Eligible role, you can choose to be designated as:
1. Remote: work remotely five days per week and come into the office on occasion - you're always welcome on-site; or select
2. Hybrid: work remotely up to two days per week; or select
3. On-Site: work five days per week on-site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time.

#LI-Remote

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

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