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Postdoctoral Organic Synthesis Jobs (NOW HIRING)

Massgeneralbrigham

Postdoctoral Research Fellow

Boston, MA · On-site

$70K - $71K/yr

... Postdoctoral Research Fellow. The Miller Laboratory for Precision Therapeutics develops new ... Our research combines organic synthesis, bioconjugate chemistry, drug delivery, molecular imaging ...

Virginia Tech

Postdoctoral Associate

Blacksburg, VA · On-site

Postdoctoral Associate Apply now Back to search results Job no: 535860 Work type: Research Faculty ... D. in organic synthesis, asymmetric catalysis or an appropriate related field. - Experience in ...

The Pennsylvania State University

... postdoctoral researcher to work in the areas of biocatalysis and synthetic chemistry. Applicants ... Candidates with expertise in organic synthesis, enzyme studies, or related areas are especially ...

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Postdoctoral Organic Synthesis information

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How much do postdoctoral organic synthesis jobs pay per year?

As of Sep 7, 2026, the average yearly pay for postdoctoral organic synthesis in the United States is $59,022.00, according to ZipRecruiter salary data. Most workers in this role earn between $49,000.00 and $66,500.00 per year, depending on experience, location, and employer.

What is a postdoctoral organic synthesis?

A Postdoctoral Organic Synthesis position is a research-focused role for individuals who have recently completed their PhD in chemistry or a related field, specializing in the design and construction of organic molecules. Postdoctoral researchers in organic synthesis work in academic, government, or industrial laboratories to develop new synthetic methodologies, optimize reactions, and contribute to scientific publications. These positions are typically temporary, lasting one to three years, and serve as a bridge between doctoral studies and permanent research or faculty roles. The work often involves collaboration with other scientists, mentoring graduate students, and presenting research findings at conferences.

What are the key skills and qualifications needed to thrive as a postdoctoral organic synthesis researcher?

To thrive as a Postdoctoral Organic Synthesis researcher, you need a PhD in organic chemistry, advanced knowledge of synthetic methodologies, and experience with multi-step synthesis. Familiarity with analytical instruments such as NMR, HPLC, and mass spectrometry, as well as literature search tools like SciFinder, is typically required. Strong problem-solving skills, attention to detail, and the ability to communicate results clearly are standout soft skills in this role. These competencies are essential for advancing complex research projects, ensuring experimental accuracy, and contributing effectively to scientific teams.

What are some common challenges faced by postdoctoral organic synthesis researchers, and how can they be addressed?

Postdoctoral researchers in organic synthesis often encounter challenges such as optimizing complex multi-step reactions, troubleshooting unexpected results, and managing tight project deadlines. Collaboration with other chemists and regular communication with supervisors can help overcome technical hurdles. Staying organized, keeping detailed lab notebooks, and remaining adaptable to changes in research direction are vital for success. Engaging in lab meetings and networking within the scientific community also helps in sharing knowledge and finding solutions to common problems.

What is the difference between Postdoctoral Organic Synthesis vs Postdoctoral Medicinal Chemistry?

AspectPostdoctoral Organic Synthesis

Postdoctoral Organic Synthesis focuses on designing, developing, and optimizing chemical reactions to create complex organic molecules. It often involves laboratory experimentation, synthesis of new compounds, and publication of research findings. This role typically requires a Ph.D. in Chemistry or a related field, with skills in laboratory techniques and organic reaction mechanisms. The work environment is primarily research labs in academia or industry, and the role is often a stepping stone for academic or industrial careers in chemical research.

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Postdoctoral Organic Synthesis jobs near you
Infographic showing various Postdoctoral Organic Synthesis job openings in the United States as of August 2026, with employment types broken down into 75% Full Time, 22% Part Time, 1% Temporary, 1% Contract, and 1% Nights. Highlights an 84% Physical, 2% Hybrid, and 14% Remote job distribution, with an average salary of $59,022 per year, or $28.4 per hour.

Postdoctoral Research Fellow

Massgeneralbrigham

Boston, MA • On-site

$70K - $71K/yr

Full-time

Re-posted 7 days ago

Key responsibilities

  • Lead projects involving radiation-activated chemistry, drug conjugates, and externally triggered therapeutic systems.

  • Design and synthesize radiation-responsive linkers and prodrugs, and develop antibody, protein, polymer, or nanoparticle conjugates.

  • Characterize new compounds using analytical methods such as HPLC, LC-MS, and NMR spectroscopy.

Mass General Brigham rating

8.0

Company rating: 8.0 out of 10

Based on 348 frontline employees who took The Breakroom Quiz

90th of 898 rated healthcare providers

Job description

Site: Massachusetts General Physicians Organization, Inc.


Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham.


Job Summary

The Miller Laboratory at the Massachusetts General Hospital Center for Systems Biology is recruiting a full-time Postdoctoral Research Fellow. The Miller Laboratory for Precision Therapeutics develops new chemical and nanotechnology-based approaches for spatially controlled cancer therapy. Our research combines organic synthesis, bioconjugate chemistry, drug delivery, molecular imaging, cancer biology, immunology, and quantitative tissue analysis to understand and engineer how therapeutics behave within tumors.
The successful candidate will lead projects involving radiation-activated chemistry, drug conjugates, and externally triggered therapeutic systems. Research may include the design and organic synthesis of radiation-responsive linkers and prodrugs; development of antibody, protein, polymer, or nanoparticle conjugates; investigation of radiation-mediated payload activation; and characterization of new compounds using HPLC, LC-MS, NMR spectroscopy, and related analytical methods.
Projects may also incorporate radiopharmaceuticals, ultrasound-responsive drug delivery, bioorthogonal chemistry, molecular imaging, and studies of the tumor immune microenvironment. Therapeutic distribution and response may be evaluated using preclinical tumor models, multiplex tissue imaging, flow cytometry, single-cell analysis, and spatial-omics techniques.
The fellow will work within a multidisciplinary environment and collaborate with chemists, cancer biologists, immunologists, engineers, imaging scientists, radiation oncologists, and other physician-scientists across Massachusetts General Hospital and the broader Harvard research community.


Qualifications

Education

PhD or equivalent doctoral degree in organic chemistry, chemical biology, biological chemistry, medicinal chemistry, materials chemistry, bioengineering, or a related discipline.
Experience

  • Strong hands-on experience in organic synthesis and/or bioconjugate chemistry.

  • Experience in at least one additional relevant area, such as nanoparticle formulation, polymer chemistry, medicinal chemistry, biomaterials, or drug delivery.

  • Ability to work effectively both independently and as part of a multidisciplinary research team.

  • Candidates who expect to complete their doctoral degree before the anticipated start date are encouraged to apply.

Knowledge, Skills and Abilities

  • Experience in one or more of the following areas is beneficial:

  • Antibody-drug, protein-drug, or polymer-drug conjugates.

  • Stimuli-responsive or activatable chemistry.

  • Nanoparticle formulation and physicochemical characterization.

  • Radiochemistry and radiopharmaceuticals.

  • Cancer biology, tumor models, or cancer immunology.

  • Molecular imaging and microscopy.

  • Ultrasound-responsive materials or drug-delivery systems.

  • Pharmacology, pharmacokinetics, or biodistribution.

  • Flow cytometry, multiplex tissue imaging, single-cell sequencing, or spatial omics.

Applicants are not expected to have experience in all of these areas. Candidates with strong chemistry backgrounds who are interested in expanding into cancer biology, imaging, immunology, and translational therapeutics are particularly encouraged to apply.


Additional Job Details (if applicable)

The salary for this position ranges from $70,000 to $71,750.

We're excited to learn more about you! To apply for this position, please email your CV and cover letter directly to Miles Miller at Miles.Miller@MGH.HARVARD.EDU.

Please do not apply through this link.


Remote Type

Onsite


Work Location

185 Cambridge Street


EEO Statement:

1300 Massachusetts General Physicians Organization, Inc. is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran's Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at (857)-282-7642.


Mass General Brigham Competency Framework

At Mass General Brigham, our competency framework defines what effective leadership "looks like" by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.

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