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What are some typical challenges faced by postdocs specializing in RNA biology, and how can they be addressed?

Postdocs in RNA biology often encounter challenges such as mastering rapidly evolving experimental techniques, managing complex datasets, and balancing independent research with collaborative projects. Staying up-to-date with the latest advances in RNA sequencing and analysis requires continuous learning and adaptability. Building strong communication and networking skills can help overcome these challenges, as collaboration with bioinformaticians, principal investigators, and other lab members is crucial for success. Regularly attending seminars and workshops also supports professional growth and keeps postdocs at the forefront of new discoveries.

What does a Postdoc in RNA Biology do?

A Postdoc in RNA Biology conducts advanced research on the structure, function, and regulation of RNA molecules within cells. Their work often involves designing and performing experiments, analyzing data, and publishing results related to topics such as RNA processing, gene expression, or RNA-based therapeutics. They may also collaborate with other scientists, mentor students, and contribute to grant writing. The goal is to expand scientific understanding of RNA biology and its implications for health and disease.

What are the key skills and qualifications needed to thrive as a Postdoc in RNA Biology, and why are they important?

To thrive as a Postdoc in RNA Biology, you need a PhD in molecular biology, biochemistry, or a related field, with deep expertise in RNA mechanisms and experimental design. Familiarity with advanced laboratory techniques such as RNA-seq, qRT-PCR, CRISPR/Cas9, and bioinformatics tools is typically required. Strong analytical thinking, problem-solving, and collaborative communication skills help drive innovative research and effective teamwork. These skills are crucial for advancing scientific knowledge, publishing impactful results, and contributing to dynamic research environments.
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What cities in California are hiring for Postdoc Rna Biology jobs? Cities in California with the most Postdoc Rna Biology job openings:
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Infographic showing various Postdoc Rna Biology job openings in California as of July 2026, with employment types broken down into 100% Full Time. Highlights an 100% In-person job distribution.
Postdoctoral Fellow - Cancer Research and RNA-Based Therapeutics

Postdoctoral Fellow - Cancer Research and RNA-Based Therapeutics

City of Hope

Monrovia, CA

Full-time

Posted 11 days ago

City Of Hope rating

8.4

Company rating: 8.4 out of 10

Based on 88 frontline employees who took The Breakroom Quiz

27th of 890 rated healthcare providers

Job description

Join the forefront of groundbreaking research at City of Hope where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research.

The laboratory of Dr. Jianjun Chen is in search of a talented Postdoctoral Fellow. Our group is interested in discovering novel genetic and epigenetic regulations and deciphering their underlying molecular mechanisms in normal developmental processes and tumorigenesis. Our research spans multiple areas, including RNA Biology, Cancer Biology, Chromatin and Epigenetic Regulation, Cancer Metabolism, Immunology, Drug Discovery and Development, and Structural Biology, with a particular emphasis on RNA epigenetics/epitranscriptomics (RNA modifications) and RNA-based therapeutics. A major focus of our translational efforts is the development of mRNA-based therapeutics, particularly in vivo CAR-T/NK/Macrophage technologies and cancer mRNA vaccines, as well as epitranscriptomics-based biomarkers for cancer diagnosis, prognosis, and therapeutic response prediction. Our research involves experiments with RNA Biology, RNA modifications/editing, mRNA-based therapeutics, lipid nanoparticle (LNP) and alternative delivery systems, targeted delivery, cancer immunology, auto immune disease, primary human cancer cells, cancer and stem cell transplantation models, mouse genetics, molecular biology, biochemistry and cell biology, chemical biology, immunology, functional genomics, CARIPSR screening, signal transduction, single-cell sequencing, spatial sequencing, metabolism, drug development, structural biology, and large-scale data analysis and computational biology.

For more information about Dr. Chen’s lab, please visit here.

As a successful candidate, you will:

Engage in a variety of advanced techniques, including but not limited to mRNA-based technologies, LNP development, targeted delivery, Flow cytometry, mass spectrometry/quantitative phospho-profiling, CyTOF, mouse genetics models, xenograft assays, retroviral gene delivery, chemical biology, drug development, whole exome sequencing and RNA-seq-analysis of clonal evolution of cancer, dot blots, RNA modification-seq, ChIP-seq, RIP-seq, PAR-CLIP-seq, single-cell sequencing, spatial sequencing, metabolism profiling, and pre-clinical drug testing in xenotransplantation models, etc.

Your qualifications should include:

A Ph.D. and/or M.D. degree(s), and a solid background in RNA biology, RNA-based therapeutics, RNA modifications/editing, epitranscriptomics, chromatin remodeling, mRNA-based therapeutics, drug discovery, drug delivery, biochemistry, chemical biology, development, epigenetics, immunology, tumor immunity, tumor microenvironment, pathology, metabolism, structural biology, and/or stem cell research.

Preferred qualifications:

  • Mouse model research experience is a plus.

City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location.

City of Hope is an equal opportunity employer.

To learn more about our Comprehensive Benefits, please CLICK HERE.

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About City of Hope

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City of Hope is an independent biomedical research and treatment organization for cancer, diabetes and other life-threatening diseases. Founded in 1913, City of Hope is a leader in bone marrow transplantation and immunotherapy such as CAR T cell therapy. City of Hopes translational research and personalized treatment protocols advance care throughout the world. Human synthetic insulin, monoclonal antibodies and numerous breakthrough cancer drugs are based on technology developed at the institution. AccessHope, a subsidiary launched in 2019 serves employers and their health care partners by providing access to City of Hopes specialized cancer expertise. City of Hope is ranked among the nations Best Hospitals in cancer by U.S. News & World Report and received Magnet Recognition from the American Nurses Credentialing Center. Its main campus is located near Los Angeles, with additional locations throughout Southern California and in Arizona.

Industry

Hospitals

Company size

1,001 - 5,000 Employees

Headquarters location

Duarte, CA, US

Year founded

1913

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