Portfolio Risk Manager Jobs in Kentucky (NOW HIRING)

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Let’s do this. Let’s change the world. In this vital role you will lead portfolio analysis, performance tracking, and benchmarking, while owning Amgen’s Probability of Technical and Regulatory Success (PTRS) process across the R&D portfolio.

You will serve as a strategic thought partner to Product Teams, Therapeutic Area and Portfolio Governance, translating development risks, evidence, and uncertainty into decision-ready options. You will also oversee technology initiatives that enable PTRS and broader portfolio decision support, working closely with the Technology, Research, and Development organizations, Product Teams, and other cross-functional partners

• Lead and facilitate the enterprise PTRS assessment process with Product Teams and cross-functional experts at key development, investment, and governance milestones.
• Own and continuously evolve the PTRS methodology, standards, benchmarks, guardrails, governance cadence, and documentation, including integration with portfolio and business-case processes.
• Oversee development of new PTRS and risk‑assessment tools with the Technology organization and functional experts, including data products, evidence workflows, dashboards, and decision‑support capabilities.

• Partner with Product Teams to assess risk across alternative target product profiles, indication and population choices, biomarker strategies, and clinical development options.
• Facilitate evidence‑based discussions that distinguish established evidence from key assumptions, clarify what would confirm, challenge, or disconfirm the current risk posture, and help teams articulate trade‑offs across risk, value, timing, cost, and resource demand.

• Support portfolio reviews, prioritization, and investment decisions by assessing portfolio‑level trade‑offs across risk, value, timing, cost, and resources and developing clear options for Governance and senior leaders.
• Lead cross‑functional portfolio performance tracking and industry benchmark participation across cycle times, success rates, portfolio composition, productivity, throughput, and other development KPIs to identify trends, gaps, and improvement opportunities.

• Deliver decision‑ready insights on portfolio risk, value, performance, and key trade‑offs for Product Teams, Governance, and senior leadership. Maintain consistency across PTRS, valuation, planning, and governance assumptions, and use historical outcomes, internal performance trends, and external benchmarks to calibrate assessments and improve decision quality over time.

We are all different, yet we all use our unique contributions to serve patients. The professional we seek is dynamic, goal oriented and results driven with these qualifications:

Doctorate degree and 2 years of experience in R&D portfolio management, portfolio analytics, life sciences or management consulting, or leading decision analysis initiatives.

OR

Master’s degree and 4 years of experience in R&D portfolio management, portfolio analytics, life sciences or management consulting, or leading decision analysis initiatives.

OR

Bachelor’s degree and 6 years of experience in R&D portfolio management, portfolio analytics, life sciences or management consulting, or leading decision analysis initiatives.

OR

Associate’s degree and 10 years of experience in R&D portfolio management, portfolio analytics, life sciences or management consulting, or leading decision analysis initiatives.

OR

High school diploma / GED and 12 years of experience in R&D portfolio management, portfolio analytics, life sciences or management consulting, or leading decision analysis initiatives.

• Advanced degree in business, life sciences, medicine, statistics, decision sciences, or a related field preferred.

• 5+ years of experience in R&D portfolio management, portfolio analytics, life sciences or management consulting, or leading decision analysis initiatives.

• Working knowledge of decision analysis methodologies and probabilistic modeling techniques (e.g., decision trees, Monte Carlo simulation, risk modeling).

• Experience facilitating PTRS, probability of success (PoS), or comparable development risk assessments with cross‑functional subject matter experts.

• Deep understanding of the end‑to‑end drug development process and the scientific, clinical, regulatory, CMC, operational, and competitive factors that influence program risk and probability of success.

• Comfort using AI‑enabled tools and analytical capabilities to synthesize evidence, assess risk, develop insights, and improve decision support; experience applying these tools in an R&D, portfolio, or strategy setting.

• Strong analytical and strategic thinking skills, with the ability to synthesize complex information into clear, actionable insights.

• Executive presence and exceptional communication skills, with the ability to influence and engage senior leaders in both formal presentations and ad hoc discussions.

• Demonstrated ability to thrive in a fast‑paced, ambiguous, and highly matrixed environment

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales‑based incentive plan
• Stock‑based long‑term incentives
• Award‑winning time‑off plans
• Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.

In any materials you submit, you may redact or remove age‑identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Sponsorship for this role is not guaranteed.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.